Patents by Inventor Gregory Hiller

Gregory Hiller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of copper and glutamate in cell culture for production of polypeptides
    Patent number: 9012180
    Abstract: An improved system for large scale production of polypeptides in cell culture is provided. In accordance with the present invention, cells expressing a polypeptide of interest are grown in media that contain copper, glutamate or both. The use of such a system allows production of polypeptides in which misfolding and/or aggregation are reduced, and in which total glycosylation is increased. Polypeptides expressed in accordance with the present invention may be advantageously used in the preparation of pharmaceutical, agricultural or other commercial compositions.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: April 21, 2015
    Assignee: Wyeth LLC
    Inventors: Denis Drapeau, Jessica Snow, Gregory Hiller, Yen Tung Luan
  • Use of Copper Glutamate in Cell Culture for Production of Polypeptides
    Publication number: 20090068705
    Abstract: An improved system for large scale production of polypeptides in cell culture is provided. In accordance with the present invention, cells expressing a polypeptide of interest are grown in media that contain copper, glutamate or both. The use of such a system allows production of polypeptides in which misfolding and/or aggregation are reduced, and in which total glycosylation is increased. Polypeptides expressed in accordance with the present invention may be advantageously used in the preparation of pharmaceutical, agricultural or other commercial compositions.
    Type: Application
    Filed: February 29, 2008
    Publication date: March 12, 2009
    Applicant: Wyeth
    Inventors: Denis Drapeau, Jessica Snow, Gregory Hiller, Yen Tung Luan