Patents by Inventor Gregory Hudalla

Gregory Hudalla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeted effector proteins and uses thereof
    Patent number: 11603394
    Abstract: Provided herein are targeted effector fusion proteins, complexes thereof, and uses thereof. The targeted effector fusion proteins can include an effector protein that can be linked to a targeting moiety. Monomer targeted effector fusion proteins can form homogeneous or heterogeneous complexes. The targeted effector fusion proteins and complexes thereof can be formulated as pharmaceutical formulations. The targeted effector fusion proteins, complexes thereof, and formulations thereof can be administered to a subject in need thereof.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: March 14, 2023
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Gregory Hudalla, Sabrina Freeman, Antonietta Restuccia, Margaret Mary Fettis, Evelyn R. Bracho-Sanchez, Shaheen Farhadi, Benjamin G. Keselowsky
  • TARGETED EFFECTOR PROTEINS AND USES THEREOF
    Publication number: 20190218264
    Abstract: Provided herein are targeted effector fusion proteins, complexes thereof, and uses thereof. The targeted effector fusion proteins can include an effector protein that can be linked to a targeting moiety. Monomer targeted effector fusion proteins can form homogeneous or heterogeneous complexes. The targeted effector fusion proteins and complexes thereof can be formulated as pharmaceutical formulations. The targeted effector fusion proteins, complexes thereof, and formulations thereof can be administered to a subject in need thereof.
    Type: Application
    Filed: October 4, 2017
    Publication date: July 18, 2019
    Inventors: GREGORY HUDALLA, SABRINA FREEMAN, ANTONIETTA RESTUCCIA, MARGARET FETTIS, EVELYN R. BRACHO-SANCHEZ, SHAHEEN FARHADI, BENJAMIN G. KESELOWSKY
  • CO-ASSEMBLY PEPTIDES, NANOSTRUCTURES, AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20180044379
    Abstract: Provided herein are charge complementary peptides that can be optionally coupled to a cargo polypeptide that are capable of self-assembling under stimulating conditions. The charge complementary peptides can be capable of forming supramolecular structures. Also provided herein are methods of using the charge complementary peptides provided herein.
    Type: Application
    Filed: August 9, 2017
    Publication date: February 15, 2018
    Inventors: Gregory A. Hudalla, Dillon T. Seroski
  • METHODS AND COMPOSITIONS INVOLVING FIBRILLIZING POLYPEPTIDES FOR NANOFIBERS
    Publication number: 20160074488
    Abstract: Embodiments of the invention are directed to fibrillar adjuvants. For example, epitopes assembled by a synthetic peptide domain into nanofibers comprising a ?-fibrillization peptide may elicit high antibody titers in the absence of any adjuvant. In certain embodiments, multiple different antigens may be integrated into polypeptide nanofibers, providing biomaterials with modular and precise composition of bioactive proteins.
    Type: Application
    Filed: November 25, 2015
    Publication date: March 17, 2016
    Inventors: Joel Collier, Gregory Hudalla
  • Methods and compositions involving fibrillizing polypeptides for nanofibers
    Patent number: 9200082
    Abstract: Embodiments of the invention are directed to fibrillar adjuvants. For example, epitopes assembled by a synthetic peptide domain into nanofibers comprising a ?-fibrillization peptide may elicit high antibody titers in the absence of any adjuvant. In certain embodiments, multiple different antigens may be integrated into polypeptide nanofibers, providing biomaterials with modular and precise composition of bioactive proteins.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: December 1, 2015
    Assignee: The University of Chicago
    Inventors: Joel Collier, Gregory Hudalla
  • METHODS AND COMPOSITIONS INVOLVING FIBRILLIZING POLYPEPTIDES FOR NANOFIBERS
    Publication number: 20140273148
    Abstract: Embodiments of the invention are directed to fibrillar adjuvants. For example, epitopes assembled by a synthetic peptide domain into nanofibers comprising a ?-fibrillization peptide may elicit high antibody titers in the absence of any adjuvant. In certain embodiments, multiple different antigens may be integrated into polypeptide nanofibers, providing biomaterials with modular and precise composition of bioactive proteins.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Inventors: JOEL COLLIER, GREGORY HUDALLA
  • Spatial control of signal transduction
    Publication number: 20060246583
    Abstract: Substrates and matrices for spatial control of signal transduction by a biologically active, soluble molecule that transduces a signal to a cell responsive to the molecule are disclosed.
    Type: Application
    Filed: April 27, 2006
    Publication date: November 2, 2006
    Inventors: William Murphy, Gregory Hudalla