Patents by Inventor Gregory J. Carven

Gregory J. Carven has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tissue factor pathway inhibitor antibodies and uses thereof
    Patent number: 10550200
    Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: February 4, 2020
    Assignee: Pfizer Inc.
    Inventors: Debra Pittman, James R. Apgar, Zong Sean Juo, Macy Jin, Mark Stahl, Gregory J. Carven, Matthew Holsti, Susan Benard, Sunita R. Hett, Reema Jasuja
  • TGFBeta Antibodies, Methods and Uses
    Publication number: 20190292254
    Abstract: ProTGFB1-GARP complex-selective antibodies, polynucleotides capable of encoding the proTGFB1-GARP complex-selective antibodies or antigen-binding fragments, cells expressing proTGFB1-GARP complex-selective antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled proTGFB1-GARP complex-selective antibodies or antigen-binding fragments may be used to enhance an immune response in a subject, for example, against a cancer.
    Type: Application
    Filed: July 14, 2017
    Publication date: September 26, 2019
    Inventors: Gregory J. Carven, Thomas Schurpf, Katherine Turner
  • ISOFORM-SPECIFIC, CONTEXT-PERMISSIVE TGFB1 INHIBITORS AND USE THEREOF
    Publication number: 20190209682
    Abstract: Disclosed herein are therapeutic use of isoform-specific, context-permissive inhibitors of TGF?1 in the treatment of disease that involve TGF?1 dysregulation.
    Type: Application
    Filed: March 22, 2019
    Publication date: July 11, 2019
    Inventors: Thomas Schurpf, Abhishek Datta, Gregory J. Carven, Constance Martin, Ashish Kalra, Kimberly Long, Alan Buckler
  • TGFbeta1-BINDING IMMUNOGLOBULINS AND USE THEREOF
    Publication number: 20190071493
    Abstract: Disclosed herein are immunoglobulins, such as antibodies, and antigen binding portions thereof, that specifically bind complexes of GARP-TGF?1, LTBP1-TGF?1, LTBP3-TGF?1, and/or LRRC33-TGF?1. The application also provides methods of use of these immunoglobulins for, for example, inhibiting TGF?1 activity, and treating subjects suffering from TGF?1-related disorders, such as cancer and fibrosis.
    Type: Application
    Filed: March 10, 2017
    Publication date: March 7, 2019
    Inventors: Thomas Schurpf, Gregory J. Carven, Abhishek Datta, Kimberly Long
  • ANTI-PRO/LATENT-MYOSTATIN ANTIBODIES AND USES THEREOF
    Publication number: 20180344844
    Abstract: Aspects of the present disclosure relate to antibodies that specifically bind proMyostatin and/or latent Myostatin and uses thereof.
    Type: Application
    Filed: September 15, 2016
    Publication date: December 6, 2018
    Inventors: Gregory J. Carven, Michelle Straub, Adriana Donovan, Katherine Jane Turner
  • ISOFORM-SPECIFIC, CONTEXT-PERMISSIVE TGFB1 INHIBITORS AND USE THEREOF
    Publication number: 20180207267
    Abstract: Disclosed herein are therapeutic use of isoform-specific, context-permissive inhibitors of TGF?1 in the treatment of disease that involve TGF?1 dysregulation.
    Type: Application
    Filed: January 5, 2018
    Publication date: July 26, 2018
    Inventors: Thomas Schurpf, Abhishek Datta, Gregory J. Carven, Constance Martin, Ashish Kalra, Kimberly Long, Alan Buckler
  • ANTI-PRO/LATENT-MYOSTATIN ANTIBODIES AND USES THEREOF
    Publication number: 20170333558
    Abstract: Aspects of the present disclosure relate to antibodies that specifically bind proMyostatin and/or latent Myostatin and uses thereof.
    Type: Application
    Filed: November 6, 2015
    Publication date: November 23, 2017
    Inventors: Michelle Straub, Dong Yun Lee, William K. McConaughy, Jared J. Sheehan, Katherine Jane Turner, Nagesh K. Mahanthappa, Gregory J. Carven, Justin W. Jackson
  • TISSUE FACTOR PATHWAY INHIBITOR ANTIBODIES AND USES THEREOF
    Publication number: 20170073428
    Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
    Type: Application
    Filed: August 17, 2016
    Publication date: March 16, 2017
    Inventors: Debra Pittman, James R. Apgar, Zong Sean Juo, Macy Jin, Mark Stahl, Gregory J. Carven, Matthew Holsti, Susan Benard, Sunita R. Hett, Reema Jasuja
  • Major histocompatibility complex (MHC)-peptide arrays
    Publication number: 20040248205
    Abstract: This invention relates to arrays of immobilized major histocompatibility complex (MHC)-peptide complexes and methods for using them.
    Type: Application
    Filed: April 14, 2004
    Publication date: December 9, 2004
    Inventors: Lawrence J. Stern, Jennifer D. Stone, Gregory J. Carven, Sriram Chitta, Iwona Strug, Jennifer R. Cochran