Abstract: An improved injection mold for forming an injection molded component. The injection mold includes a main cavity block and a main core block that are moveable with respect to one another. The main cavity block has a cavity block mating face that includes a first mold surface and the main core block has a core block mating face that includes a second mold surface. A plurality of induction heating coils extend within the main cavity block and a plurality of gas inlet channels extend through the main core block. The second mold surface includes a plurality ridges that cooperatively form a continuous gas flow path that is disposed in fluid communication with the plurality of as inlet channels. The continuous gas flow path follows a serpentine shape to provide even and uninterrupted gas flow across the second mold surface.

Abstract: Provided herein are compositions and methods for treating ER+, HER2? HRG+ breast cancer (e.g., metastatic ER+, HER2? breast cancer) in a patient by administering to the patient an anti-ErbB3 antibody (e.g., seribantumab), a CDK4/6 inhibitor (e.g., palbociclib), and an endocrine based therapy (e.g., letrozole or fulvestrant) according to a particular clinical dosage regimen (i.e., at a particular dose amount and according to a specific dosing schedule). Also provided herein are compositions and methods for treating ER+, HER2? HRG+ breast cancer (e.g., metastatic ER+, HER2? breast cancer) in a patient by administering to the patient an anti-ErbB3 antibody (e.g., seribantumab) and an endocrine based therapy (e.g., letrozole or fulvestrant) according to a particular clinical dosage regimen (i.e., at a particular dose amount and according to a specific dosing schedule).

Abstract: Anti-FGFR antibodies which bind to particular isoforms of FGFR1-4, therapeutic compositions comprising the anti-FGFR antibodies, and methods of using such antibodies and compositions in the treatment of FGFR-related disorders (e.g., cancer) are disclosed.

Abstract: An improved injection mold for forming an injection molded component. The injection mold includes a main cavity block and a main core block that are moveable with respect to one another. The main cavity block has a cavity block mating face that includes a first mold surface and the main core block has a core block mating face that includes a second mold surface. A plurality of induction heating coils extend within the main cavity block and a plurality of gas inlet channels extend through the main core block. The second mold surface includes a plurality ridges that cooperatively form a continuous gas flow path that is disposed in fluid communication with the plurality of as inlet channels. The continuous gas flow path follows a serpentine shape to provide even and uninterrupted gas flow across the second mold surface.

Abstract: The disclosure provides methods of treatment for cancer in patients using bispecific anti-IGF-1R, anti-ErbB3 antibodies in combination with one or more therapeutic agents that impede regulatory T-cell agents. In certain embodiments, said one or more therapeutic agent may be an antagonistic anti-receptor antibody that immunospecifically binds human PD-L1.

Abstract: A sealable container (210) for flowable material formed with top (212) and flexible and stiffened bottom (214) walls joined by front (216), rear (218), and opposite side walls (220, 222). The top wall including an openable lid (D) formed with an improved scoop holder (30) and a collar (300) received about a finish (282) of the front, rear, and side walls. The flexible and stiffened bottom wall (214) includes at least one sagittal stiffening channel (500) and an optional transverse stiffening channel (530). The openable lid includes a sealing wall (340) that cooperates with other improved container components to prevent spillage of the flowable material after the seal is peeled and removed.

Abstract: A sealable container (210) for flowable material formed with top (212) and flexible and stiffened bottom (214) walls joined by front (216), rear (218), and opposite side walls (220, 222). The top wall including an openable lid (D) formed with an improved scoop holder (30) and a collar (300) received about a finish (282) of the front, rear, and side walls. The flexible and stiffened bottom wall (214) includes at least one sagittal stiffening channel (500) and an optional transverse stiffening channel (530). The openable lid includes a sealing wall (340) that cooperates with other improved container components to prevent spillage of the flowable material after the seal is peeled and removed.