Abstract: Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGF?1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

Abstract: Systems and methods for nitric oxide (NO) delivery are provided. A NO delivery system can include one or more pairs of electrodes configured to ionize a reactant gas into an NO-containing product gas, a delivery line to deliver at least a portion of the product gas into an inspiratory flow of gas, and a controller. The controller is configured to control an amount of NO in the product gas generated by the one or more pairs of electrodes using one or more parameters as input to the at least one controller. One of the parameters is a dilution value derived as a function of an inspiratory flow rate and a target inspiratory gas NO concentration level. The dilution value is used by the controller to set a flow rate of the product gas injected into the inspiratory flow and to determine a target concentration of NO in the product gas.

Abstract: A system for managing media files having different format characteristics includes a transcoder, a content store, and a plurality of clients. The content store is capable of storing a media file in a first format. The clients are each associated with one or more media file formats and capable of playing media files to users. The transcoder is capable of receiving a request identifying a media file from a first client and, in response to receiving the request, retrieving the media file from the content store in a first format. The transcoder is also operable of modifying the media file from the first format to a second format associated with the first client and, while modifying the media file from the first format to the second format, transmitting a modified portion of the media file to the first client.

Abstract: A system for managing media files having different format characteristics includes a transcoder, a content store, and a plurality of clients. The content store is capable of storing a media file in a first format. The clients are each associated with one or more media file formats and capable of playing media files to users. The transcoder is capable of receiving a request identifying a media file from a first client and, in response to receiving the request, retrieving the media file from the content store in a first format. The transcoder is also operable of modifying the media file from the first format to a second format associated with the first client and, while modifying the media file from the first format to the second format, transmitting a modified portion of the media file to the first client.

Abstract: Systems and methods are provided for network connected content delivery systems that employ functional multi-processing to optimize bandwidth utilization and accelerate system performance. In one embodiment, the content delivery system may include a switch based computing system. The system may further include an asymmetric multi-processor system configured in a staged pipeline manner.

Abstract: Systems and methods are provided for network connected computing systems that employ functional multi-processing to optimize bandwidth utilization and accelerate system performance. In one embodiment, the network connected computing system may include a switch based computing system. The system may further include an asymmetric multi-processor system configured in a staged pipeline manner. The network connected computing system may be utilized in one embodiment as a network endpoint system that provides content delivery.

Abstract: Methods and systems for providing differentiated service that may be employed, for example, to deliver content or services in a network environment. Differentiated services that may be so delivered include both differentiated information service that may be implemented, for example, at the system and/or processing level, as well as differentiated business service that may be implemented, for example, to differentiate information exchange between different network entities such as different network provider entities, different network user entities, etc. The methods and systems may include or facilitate provisioning of system service parameters such as service level agreement (“SLA”) policies and may be employed in network computing system environments to enable differentiated service provisioning, for example, in accordance with business objectives.

Abstract: Systems and methods are provided for network connected computing systems that employ functional multi-processing to optimize bandwidth utilization and accelerate system performance. In one embodiment, the network connected computing system may include a switch based computing system. The system may further include an asymmetric multi-processor system configured in a staged pipeline manner. The components of the system may communicate as peers in a peer to peer environment. The network connected computing system may be utilized in one embodiment as a network endpoint system that provides content delivery.

Abstract: Methods and systems for providing differentiated service that may be employed, for example, to deliver content or services in a network environment. Differentiated services that may be so delivered include both differentiated information service that may be implemented, for example, at the system and/or processing level, as well as differentiated business service that may be implemented, for example, to differentiate information exchange between different network entities such as different network provider entities, different network user entities, etc. The methods and systems may include or facilitate provisioning of system service parameters such as service level agreement (“SLA”) policies and may be employed in network computing system environments to enable differentiated service provisioning, for example, in accordance with business objectives.

Abstract: Logging and analysis of resource utilization information may be implemented, for example, to achieve intelligent capacity management of information management system resources. In one implementation, resource utilization information may be collected from one or more subsystems or processing engines of an information management system, and analyzed to gain insights into system performance. System capacity management may be implemented using collected resource utilization information, for example, to achieve dynamic management of system resources.

Abstract: A distributed interconnect may be employed in information management environments to distribute functionality, for example, among processing engines of an information management system and/or processing modules thereof. Distributive interconnects such as switch fabrics and virtual distributed interconnect backplanes, may be employed to establish independent paths from node to node and thus may be used to facilitate parallel and independent operation of each processing engine of a multi-processing engine information management system, e.g. to provide peer-to-peer communication between the engines on an as-needed basis. These and other features of distributed interconnects may be advantageously employed to optimize information management systems operations in a variety of system configurations.

Abstract: Systems and methods are provided for network connected computing systems that employ functional multi-processing to optimize bandwidth utilization and accelerate system performance. In one embodiment, the network connected computing system may include a switch based computing system. The system may further include an asymmetric multi-processor system configured in a staged pipeline manner. The network connected computing system may be utilized in one embodiment as a network endpoint system that provides content delivery.

Abstract: Systems and methods are provided for network connected computing systems that employ functional multi-processing to optimize bandwidth utilization and accelerate system performance. In one embodiment, the network connected computing system may include a switch based computing system. The system may further include an asymmetric multi-processor system configured in a staged pipeline manner. The network connected computing system may be utilized in one embodiment as a network endpoint system that provides content delivery.

Abstract: Systems and methods are provided for network connected computing systems that employ functional multi-processing to optimize bandwidth utilization and accelerate system performance. In one embodiment, the network connected computing system may include a switch based computing system. The system may further include an asymmetric multi-processor system configured in a staged pipeline manner. The network connected computing system may be utilized in one embodiment as a network endpoint system that provides content delivery.

Abstract: Systems and methods are provided for network connected computing systems that employ functional multi-processing to optimize bandwidth utilization and accelerate system performance. In one embodiment, the network connected computing system may include a switch based computing system. The switch employed in the system may be a switch fabric. The system may further include an asymmetric multi-processor system configured in a staged pipeline manner. The network connected computing system may be utilized in one embodiment as a network endpoint system that provides content delivery.

Abstract: Methods and systems for providing differentiated service that may be employed, for example, to deliver content or services in a network environment. Differentiated services that may be so delivered include both differentiated information service that may be implemented, for example, at the system and/or processing level, as well as differentiated business service that may be implemented, for example, to differentiate information exchange between different network entities such as different network provider entities, different network user entities, etc. The methods and systems may include or facilitate provisioning of system service parameters such as service level agreement (“SLA”) policies and may be employed in network computing system environments to enable differentiated service provisioning, for example, in accordance with business objectives.

Abstract: Methods and systems for providing differentiated service that may be employed, for example, to deliver content or services in a network environment. Differentiated services that may be so delivered include both differentiated information service that may be implemented, for example, at the system and/or processing level, as well as differentiated business service that may be implemented, for example, to differentiate information exchange between different network entities such as different network provider entities, different network user entities, etc. The methods and systems may include or facilitate provisioning of system service parameters such as service level agreement (“SLA”) policies and may be employed in network computing system environments to enable differentiated service provisioning, for example, in accordance with business objectives.

Abstract: Methods and systems for providing differentiated service that may be employed, for example, to deliver content or services in a network environment. Differentiated services that may be so delivered include both differentiated information service that may be implemented, for example, at the system and/or processing level, as well as differentiated business service that may be implemented, for example, to differentiate information exchange between different network entities such as different network provider entities, different network user entities, etc. The methods and systems may include or facilitate provisioning of system service parameters such as service level agreement (“SLA”) policies and may be employed in network computing system environments to enable differentiated service provisioning, for example, in accordance with business objectives.

Abstract: Methods and systems for providing differentiated service that may be employed, for example, to deliver content or services in a network environment. Differentiated services that may be so delivered include both differentiated information service that may be implemented, for example, at the system and/or processing level, as well as differentiated business service that may be implemented, for example, to differentiate information exchange between different network entities such as different network provider entities, different network user entities, etc. The methods and systems may include or facilitate provisioning of system service parameters such as service level agreement (“SLA”) policies and may be employed in network computing system environments to enable differentiated service provisioning, for example, in accordance with business objectives.

Abstract: Methods and systems for providing differentiated service that may be employed, for example, to deliver content or services in a network environment. Differentiated services that may be so delivered include both differentiated information service that may be implemented, for example, at the system and/or processing level, as well as differentiated business service that may be implemented, for example, to differentiate information exchange between different network entities such as different network provider entities, different network user entities, etc. The methods and systems may include or facilitate provisioning of system service parameters such as service level agreement (“SLA”) policies and may be employed in network computing system environments to enable differentiated service provisioning, for example, in accordance with business objectives.