Abstract: A pediatric dosage form for dosing ultra-low doses of an active pharmaceutical ingredient having a plurality of pellets where each pellet consists essentially of a coating of tyrosine kinase inhibitor over a nonpareil seed. The tyrosine kinase inhibitor coated nonpareils are coated thereon with a coating consisting essentially of hydroxypropyl methylcellulose. The active coated beads according to the invention allows for human subject dosing on a mg/kg basis. The sum of such pellets contained within a capsule forming a single dosage unit of an ultra-low dose of tyrosine kinase inhibitor.

Abstract: A pediatric dosage form for dosing ultra-low doses of an active pharmaceutical ingredient having a plurality of pellets where each pellet consists essentially of a coating of tyrosine kinase inhibitor over a nonpareil seed. The tyrosine kinase inhibitor coated nonpareils are coated thereon with a coating consisting essentially of hydroxypropyl methylcellulose. The active coated beads according to the invention allows for human subject dosing on a mg/kg basis. The sum of such pellets contained within a capsule forming a single dosage unit of an ultra-low dose of tyrosine kinase inhibitor.