Patents by Inventor Gregory J. Sieczkiewicz

Gregory J. Sieczkiewicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered Nucleic Acids and Methods of Use Thereof
    Publication number: 20210236655
    Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful for production of proteins.
    Type: Application
    Filed: July 16, 2020
    Publication date: August 5, 2021
    Applicant: ModernaTX, Inc.
    Inventors: Jason P. Schrum, Gregory J. Sieczkiewicz, Kenechi Ejebe, Sayda M. Elbashir
  • Engineered Nucleic Acids and Methods of Use Thereof
    Publication number: 20180112221
    Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful for production of proteins.
    Type: Application
    Filed: June 1, 2017
    Publication date: April 26, 2018
    Inventors: Jason P. Schrum, Gregory J. Sieczkiewicz, Kenechi Ejebe, Sayda M. Elbashir
  • Engineered nucleic acids and methods of use thereof
    Patent number: 9701965
    Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful for production of proteins.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: July 11, 2017
    Assignee: MODERNATX, INC.
    Inventors: Jason P. Schrum, Gregory J. Sieczkiewicz, Kenechi Ejebe, Sayda M. Elbashir
  • ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF FOR NON-HUMAN VERTEBRATES
    Publication number: 20160256572
    Abstract: Provided are formulations, compositions, kits and methods for delivering biological moieties such as modified nucleic acids into cells to induce, reduce or modulate protein expression in non-human vertebrates.
    Type: Application
    Filed: April 1, 2016
    Publication date: September 8, 2016
    Inventors: Noubar B. Afeyan, Gregory J. Sieczkiewicz, Stephane Bancel
  • ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF
    Publication number: 20150064725
    Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful for production of proteins.
    Type: Application
    Filed: November 7, 2014
    Publication date: March 5, 2015
    Inventors: Jason P. Schrum, Gregory J. Sieczkiewicz, Kenechi Ejebe, Sayda M. Elbashir
  • MODIFIED MRNAS ENCODING CELL-PENETRATING POLYPEPTIDES
    Publication number: 20140371302
    Abstract: This invention relates to modified nucleic acid compositions encoding cell-penetrating polypeptides to provoke an innate immune response in a cell and methods of delivering protein-binding partners to target cells.
    Type: Application
    Filed: December 21, 2012
    Publication date: December 18, 2014
    Inventors: Noubar B. Afeyan, Gregory J. Sieczkiewicz
  • Engineered nucleic acids encoding a modified erythropoietin and their expression
    Patent number: 8710200
    Abstract: Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: April 29, 2014
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Jason P. Schrum, Noubar B. Afeyan, Gregory J. Sieczkiewicz, Stephane Bancel, Antonin de Fougerolles, Sayda M. Elbashir
  • CYTOKINE COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20120269765
    Abstract: Polypeptides, including non-naturally occurring and recombinantly modified polypeptides related to the p19 subunit of IL-23, methods of making such molecules and methods of using such molecules as therapeutic, prophylactic and diagnostic agents are provided.
    Type: Application
    Filed: July 26, 2010
    Publication date: October 25, 2012
    Inventors: K. Christopher Garcia, Patrick Lupardus, Sashank K. Reddy, Gregory J. Sieczkiewicz
  • DELIVERY AND FORMULATION OF ENGINEERED NUCLEIC ACIDS
    Publication number: 20120251618
    Abstract: Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.
    Type: Application
    Filed: April 2, 2012
    Publication date: October 4, 2012
    Applicant: modeRNA Therapeutics
    Inventors: Jason P. Schrum, Noubar B. Afeyan, Gregory J. Sieczkiewicz, Stephane Bancel, Antonin de Fougerolles, Sayda M. Elbashir
  • ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF
    Publication number: 20120237975
    Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful for production of proteins.
    Type: Application
    Filed: October 3, 2011
    Publication date: September 20, 2012
    Inventors: Jason Schrum, Gregory J. Sieczkiewicz, Kenechi Ejebe, Sayda M. Elbashir