Abstract: Presented herein are inactivated Staphylococcal bacterial immunogens. Also described herein are compositions including Staphylococcal immunogens. Methods for preparing and using the same are also described. Immunogens may enable a host immune response that can protect the host from infection and/or disease. Differential analysis of antigens that stimulate protective (immunogenic) and non-protective immunity can be used to identify correlates of protection that can be developed as subunit vaccine candidates.

Abstract: Compositions useful as poliovirus immunogens are provided along with methods and compositions for preparing the same. Compositions comprising poliovirus immunogens can enable a host response that includes virus-neutralizing antibodies which can protect the host from infection and/or disease.

Abstract: Compositions useful as poliovirus immunogens are provided along with methods and compositions for preparing the same. Compositions comprising poliovirus immunogens can enable a host response that includes virus-neutralizing antibodies which can protect the host from infection and/or disease.

Abstract: A method of positively detecting a target pathogen/molecule within a fluid sample and related test devices are described. The device includes a plurality of chambers in adjacent, spaced-apart relationship, and a plurality of isolation valves selectively actuatable to control fluid flow into and out of one or more of the plurality of chambers. The method includes providing the fluid sample into a first chamber of the device; opening a first one of the isolation valves to allow the fluid sample to flow from the first chamber into a second chamber, the second chamber containing an amplification reagent; opening a second one of the isolation valves to allow the fluid sample to flow from the second chamber into a third chamber, the third chamber containing a CRISPR/Cas reagent; illuminating the fluid sample in third chamber with light; and determining whether the fluid sample in the third chamber fluoresces in response to the light.

Abstract: Presented herein are inactivated A. baumannii immunogens. Also described herein are compositions including A. baumannii immunogens. Methods and compositions for preparing the same are also described.

Abstract: This invention provides illudin derivatives, intermediates, preparation methods, pharmaceutical compositions and uses thereof. Specific examples include novel synthetic routes to prepare illudin derivatives and an illudin derivative having a positive optical rotation, which has therapeutic value.

Abstract: This invention provides illudin derivatives, intermediates, preparation methods, pharmaceutical compositions and uses thereof. Specific examples include novel synthetic routes to prepare illudin derivatives and an illudin derivative having a positive optical rotation, which has therapeutic value.

Abstract: This invention provides illudin derivatives, intermediates, preparation methods, pharmaceutical compositions and uses thereof. Specific examples include novel synthetic routes to prepare illudin derivatives and an illudin derivative having a positive optical rotation, which has therapeutic value.

Abstract: Compositions useful as poliovirus immunogens are provided along with methods and compositions for preparing the same. Compositions comprising poliovirus immunogens can enable a host response that includes virus-neutralizing antibodies which can protect the host from infection and/or disease.

Abstract: Methods for providing novel compositions useful as influenza immunogens are provided. The compositions enable a host response to immunogen sites normally not recognized by a host. The novel immunogens can be used as vaccines or to develop antibodies.

Abstract: Novel compositions useful as influenza immunogens are provided. The compositions enable a host response to immunogen sites normally not recognized by a host.

Abstract: Methods for providing novel compositions useful as influenza immunogens are provided. The compositions enable a host response to immunogen sites normally not recognized by a host. The novel immunogens can be used as vaccines or to develop antibodies.

Abstract: Novel compositions useful as influenza immunogens are provided. The compositions enable a host response to immunogen sites normally not recognized by a host.

Abstract: Novel compositions useful as influenza immunogens are provided. The compositions enable a host response to immunogen sites normally not recognized by a host.

Abstract: The present invention provides, inter alia, recombinant chimeric nucleic acids encoding a Gag-fs-fusion partner fusion protein; a pseudovirion comprising a retroviral Gag protein and a fusion partner, wherein the fusion partner is present in a Gag-fs-fusion partner fusion protein; an immunogenic composition comprising a pseudovirion; a Gag-fs-fusion partner fusion protein; and a method of making the pseudovirions of the present invention.