Abstract: The present invention relates to protein purification, primarily in the chromatographic field. More closely, the invention relates to affinity chromatography using a split intein system with an improved C-intein tag and N-intein ligand, wherein the target protein may be purified as a tag-less end product with a native N-terminus.

Abstract: The subject matter of this specification can be embodied in, among other things, a method of igniting an air/fuel mixture in an internal combustion engine includes receiving an air/fuel mixture into a pre-combustion chamber, the pre-combustion chamber enclosing a portion of an igniter, igniting the air/fuel mixture in in the pre-combustion chamber with the igniter to produce a flame, directing the flame to eject the pre-combustion chamber through a collection of passages in a wall of the pre-combustion chamber, toward a peripheral wall of a main combustion chamber of the internal combustion engine, igniting, by the flame, air/fuel mixture in the main combustion chamber adjacent the peripheral wall, and then igniting air/fuel mixture in the main combustion chamber in a central region of the main combustion chamber with a propagating flame front of the ignited air/fuel mixture or a portion of the directed flame adjacent the peripheral wall.

Abstract: To automate time series forecasting machine learning pipeline generation, a data allocation size of time series data may be determined based on one or more characteristics of a time series data set. The time series data may be allocated for use by candidate machine learning pipelines based on the data allocation size. Features for the time series data may be determined and cached by the candidate machine learning pipelines. Predictions of each of the candidate machine learning pipelines using at least the one or more features may be evaluated. A ranked list of machine learning pipelines may be automatically generated from the candidate machine learning pipelines for time series forecasting based upon evaluating predictions of each of the one or more candidate machine learning pipelines.

Abstract: Some embodiments of the disclosure include inventive compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which inhibit IRAK and/or FLT3 and which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as hematopoietic cancers, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), etc.), Additional embodiments provide disease treatment using combinations of the inventive IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies.

Abstract: Continuous compression molding machines (CCMMs) and methods of continuous compression molding a consolidated thermoplastic matrix composite material are disclosed herein. The CCMMs include a mold, a heat zone heating structure, a consolidation zone heating structure, and a stress relaxation zone heating structure. The CCMMs also include a press structure, a demold structure, and a supply structure. The methods include providing a thermoplastic matrix composite material (TMCM) that includes a thermoplastic material to a CCMM. During the providing, the methods also include heating the TMCM within a heat zone of the CCMM, cooling and consolidating the TMCM within a consolidation zone of the CCMM, relaxing stress within the TMCM within a stress relaxation zone of the CCMM, demolding the TMCM within a demold zone of the CCMM at a mold temperature that is greater than a glass transition temperature of the thermoplastic material, and periodically compressing the TMCM.

Abstract: A mixture including a thiophosphoric acid product suitable for preparing organometallic and/or ashless antiwear additives having improved copper corrosion performance. The thiophosphoric acid product is distilled and recovered as a condensate of the distillation and having a low level of active sulfur.

Abstract: A mask assembly for use as part of an apparatus for supplying a flow of respiratory gases to a user is disclosed. The mask assembly includes a mask body having an inlet through which said flow of respiratory gases are provided to the interior of said mask body. A mask seal assembly comprising a seal of flexible material and a clip of rigid material is attached to the body. The seal has a first side and a second side. The first side of the seal is shaped to approximately match the contours of a user's face and in use substantially seal against a user's face. The second side is attached to the clip. The clip provides an interface extending substantially the full perimeter or periphery of the mask seal assembly for releasably attaching the mask seal assembly to the mask body. The clip comprises a bridging portion spanning outwards from the perimeter or periphery of the mask body to space at least a portion of the second side of the seal outwards from the perimeter or periphery of the mask body.

Abstract: The subject matter of this specification can be embodied in, among other things, a hydrogen fuel cell anode control system including a hydrogen inlet configured to receive pressurized hydrogen, a hydrogen outlet configured to be fluidically coupled to an anode manifold of a hydrogen fuel cell, a recirculation inlet configured to receive overflow hydrogen from the anode manifold, a hydrogen pressure regulator configured to receive pressurized hydrogen from the hydrogen inlet, a hydrogen recirculation module configured to mix hydrogen received from the hydrogen pressure regulator and the recirculation inlet, and provide a hydrogen mixture to the hydrogen outlet, a differential pressure measurement module configured to measure a differential pressure between the anode manifold and a cathode manifold of the hydrogen fuel cell, and a controller configured to control at least one of the hydrogen pressure regulator or the hydrogen recirculation module based on the measured differential pressure.

Abstract: A system is provided comprising a robotic instrument for use with a tool. In some versions, the robotic instrument comprises a hand-held portion to be held by a user and a tool support movably coupled to the hand-held portion to support the tool. The robotic instrument further includes an actuator assembly operatively attached to the tool support and the hand-held portion and configured to move the tool support relative to the hand-held portion in a plurality of degrees of freedom. The robotic instrument may includes a handle alignment member extending from the hand-held portion. At least a portion of the handle alignment member and a tool plane defined by the tool are aligned when the tool support has an optimal range of motion relative to the hand-held portion.

Abstract: Disclosed is a surgical fixation device to mount on bone. This device does not utilize screws and achieves stability via applying force to the inner wall of the bore and is therefore faster, easier to use, and less user dependent. The device facilitates fast, easy anchoring system for use with other devices that require rigid fixation to bone. The device provides for intermittent mounting of tools, equipment, and/or accessories to a cylindrical bore in bone for use in surgical applications without compromising surrounding bine structure such as done by the use of bone screws. Rigid fixation to bone is a common requirement for surgical procedures for placement of tools, monitoring systems, positional systems, or used as fiducial markers. The present fixation device removably mounts on bone without the disadvantages associated with bone screws and other fixation devices.

Abstract: An interface for positive pressure respiratory therapy includes a mask assembly having a mask seal and a mask shell. The mask assembly is positioned lower than and exposes a bridge of the user's nose. The mask seal includes first and second portions on respective first and second sides of a nasal region that contact opposing sides of the user's nose. The first and second portions each include supports that help maintain a shape of the mask seal. A pair of covers can be supported relative to the mask assembly and adjacent a respective one of the first and second portions of the mask seal. The covers limit expansion of the first and second portions of the mask seal in response to pressurized air within the mask seal. The supports of the first and second portions can transfer load from the mask seal to the covers.

Abstract: An oral product includes a body that is wholly receivable in an oral cavity. The body includes a mouth-soluble polymer matrix, cellulosic fibers embedded in the mouth-soluble polymer matrix, and nicotine or a derivative thereof dispersed in the mouth-soluble polymer matrix. The oral product is adapted to release the nicotine or a derivative thereof from the body when the body is received within the oral cavity and exposed to saliva.

Abstract: A composite skin is attached to an underlying structure by fasteners that are countersunk into the structure. The composite skin comprises a thermoplastic material that has been melted and formed into a countersink in the structure using a heated tool.

Abstract: A biodegradable foam which includes a polyester-based polyurethane foam and a mixture comprised of a soil-dwelling carbon-digesting bacteria embedded in a carrier compound. The mixture of the soil-dwelling carbon-digesting bacteria is homogenously dispersed throughout the polyester-based polyurethane foam. This biodegradable foam exhibits biodegradation rates higher than a polyester-based polyurethane foam absent the soil-dwelling carbon-digesting bacteria.

Abstract: An apparatus that forms bundles of glass articles includes a glass article infeed station including an infeed conveyor that continuously transports individual glass articles to a layer separating conveyor. The layer separating conveyor includes a conveyor belt that forms a layer of side-by-side glass articles. A robotic lift assembly is configured to place the layer of side-by-side glass articles together on a layer separation insert. The layer separation insert has side-by-side slots that each receive a single glass article of the layer of side-by-side glass articles.

Abstract: Particular embodiments described herein provide for an electronic device that can be configured to allow for the mitigation of ransomware. For example, the system can determine that an application begins to execute, determine that the application attempts to modify a file, determine a file type for the file, and create a security event if the application is not authorized to modify the file type. In another example, the system determines an entropy value between the file and the attempted modification of the file, and create a security event if the entropy value satisfies a threshold or determine a system entropy value that includes a rate at which other files on the system are being modified by the application, and create a security event if the system entropy value satisfies a threshold.

Abstract: A projectile designed to be lead-free and have a ballistic coefficient ranging from about 0.13 to about 0.80 or greater for enhanced energy/performance at extended ranges may have an elongated body formed with a jacket including a wall having an end defining an ogive portion and a cavity or recess defined within the jacket and in which a core is received. The projectile can be configured in various calibers and sizes. The projectile core may be formed from a plurality of core sections, and at least one of the plurality of core sections may include tungsten powder and a lead-free binder material pressed together to form a substantially cylindrical shape or compact. One or more of the core sections further can be sintered, and the one or more core sections may be received in an end-to-end relationship within the cavity defined by the jacket to form a stacked, sectional core.

Abstract: A system and method are provided for manufacturing a tower structure. Accordingly, one or more layers of a wall element are deposited with a printhead assembly. At least one recess is defined in the wall element. The recess(es) has a single, circumferential opening positioned along an inner reference curve or an outer reference curve of the wall element. The recess(es) also has a depth which extends in a radial direction and intersects a midline reference curve. A reinforcing element is placed entirely within the recess(es) at the midline reference curve.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating cystic fibrosis, e.g., in subjects having a mutation resulting in F508del, are described.

Abstract: The invention relates to the monitoring of products by means of active radio tags. According to the invention, packagings of products are provided with an active radio tag that detects at least one environmental condition and/or at least one packaging state, and which emits a signal at time intervals, which provides information about a unique identifier and at least one state in which the respective product is found. The signal is picked up by a receiver that extracts the unique identifier and the state information and transmits same together with location information to an external server.