Patents by Inventor Gregory Jay Haley

Gregory Jay Haley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chiral cis-imidazolines
    Patent number: 7964724
    Abstract: and the pharmaceutically acceptable salts and esters thereof, wherein X1, X2, X3, Y1, Y2 and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.
    Type: Grant
    Filed: May 13, 2005
    Date of Patent: June 21, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Gregory Jay Haley, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber
  • CIS-imidazolines
    Patent number: 7893278
    Abstract: The present invention relates to compounds of the formula and the pharmaceutically acceptable salts and esters thereof, a process for their manufacture, medicaments containing them as well as the use of these compounds as pharmaceutically active agents. The compounds show antiproliferative activity and may be especially useful for the treatment of cancer.
    Type: Grant
    Filed: June 2, 2005
    Date of Patent: February 22, 2011
    Assignee: Hoffman-La Roche Inc.
    Inventors: Gregory Jay Haley, Norman Kong, Emily Aijun Liu, Binh Thanh Vu
  • Cis-imidazolines
    Patent number: 7705007
    Abstract: There are provided compounds of the formula I wherein R, V1, V2 and Ring A are described herein. The compounds exhibit anticancer activity.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: April 27, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Gregory Jay Haley, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber
  • Cis-imidazolines
    Patent number: 7579368
    Abstract: There are presented compounds of the formula or pharmaceutically acceptable salts thereof, wherein Y1, Y2, X1, X2, X3 and R are as described in this application. These compounds are believed to inhibit MDM2-p53 interaction and as such the compounds will have anti-hyperproliferative cellular activity.
    Type: Grant
    Filed: March 13, 2006
    Date of Patent: August 25, 2009
    Assignee: Hoffman-La Roche Inc.
    Inventors: Nader Fotouhi, Gregory Jay Haley, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber
  • CHIRAL CIS-IMIDAZOLINES
    Publication number: 20090143364
    Abstract: and the pharmaceutically acceptable salts and esters thereof, wherein X1, X2, X3, Y1, Y2 and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.
    Type: Application
    Filed: February 5, 2009
    Publication date: June 4, 2009
    Inventors: Nader Fotouhi, Gregory Jay Haley, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber
  • Cis-imidazolines
    Patent number: 7425638
    Abstract: The present invention provides compounds according to formula I having the designations provided herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: September 16, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Gregory Jay Haley, Norman Kong, Emily Aijun Liu, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber
  • Cis-imidazolines
    Publication number: 20040259884
    Abstract: The present invention provides compounds according to formula I 1
    Type: Application
    Filed: June 14, 2004
    Publication date: December 23, 2004
    Inventors: Gregory Jay Haley, Norman Kong, Emily Aijun Liu, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber
  • Herbicidal 3-heterocyclic substituted benzisothiazole and benzisoxazole compounds
    Patent number: 6706663
    Abstract: There are provided 3-heterocyclic substituted benzisothiazole and benzisoxazole compounds having the structural formula I where Q, X, X1 and Z are defined as in claim 1. Further provided are compositions and methods comprising those compounds for the control of undesirable plant species.
    Type: Grant
    Filed: April 17, 2001
    Date of Patent: March 16, 2004
    Assignee: Wyeth
    Inventors: Peter John Wepplo, Richard Anthony Rampulla, Gavin David Heffernan, Michael Vernie Cossette, Charles Malcolm Langevine, Venkataraman Kameswaran, Robert Eugene Diehl, James Joseph Fiordeliso, Gregory Jay Haley, Michael Anthony Guaciaro
  • Herbicidal 3 -heterocyclic substituted benzisothiazole and benzisoxazole compounds
    Publication number: 20020028748
    Abstract: There are provided 3-heterocyclic substituted benzisothiazole and benzisoxazole compounds having the structural formula I 1
    Type: Application
    Filed: April 17, 2001
    Publication date: March 7, 2002
    Applicant: Intellectual Property Department BASF Aktiengesellschaft
    Inventors: Peter John Wepplo, Richard Anthony Rampulla, Gavin David Heffernan, Michael Vernie Cossette, Charles Malcolm Langevine, Venkataraman Kameswaran, Robert Eugene Diehl, James Joseph Fiordeliso, Gregory Jay Haley, Michael Anthony Guaciaro
  • 3-(1,2-Benzisothiazol- and isoxazol-5-yl)-2,4(1H,3H)-pyrimidinedione or thione and 3-(1,2-benzisothiazol- and isoxazol-5-yl)-4(3H)-pyrimidinone or thione herbicidal agents
    Patent number: 6156700
    Abstract: There are provided 3-(1,2-benzisothiazol- and isoxazol-5-yl)-2,4(1H,3H)-pyrimidinedione or thione compounds of formula I and 3-(1,2-benzisothiazol- and isoxazol-5-yl)-4(3H)-pyrimidinone or thione compounds of formula II ##STR1## Further provided are compositions and methods comprising those compounds for the control of undesirable plant species.
    Type: Grant
    Filed: September 14, 1998
    Date of Patent: December 5, 2000
    Assignee: American Cyanmid Company
    Inventors: Peter John Wepplo, Mark Christopher Manfredi, Richard Anthony Rampulla, Michael Vernie Cossette, Michael Anthony Guaciaro, Gregory Jay Haley, Billy Gene Bullock, Sergio Ivan Alvarado, Keith Douglas Barnes, Gary Allen Meier, David Allen Hunt, Marianne Carlsen, Gavin David Heffernan