Patents by Inventor Gregory Kapp

Gregory Kapp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DETECTION OF BINDING PROTEINS IN EQUILIBRIUM AND NON-EQUILIBRIUM CONDITIONS
    Publication number: 20260160760
    Abstract: Methods, systems, and compositions are provided for characterizing the interactions of binding reagents with ligand-binding proteins, such as enzymes. Unknown ligand-binding proteins may be identified at single-molecule resolution based upon their interactions with binding reagents. Proteins with unknown ligand-binding behaviors may be characterized by binding reagent methods set forth herein.
    Type: Application
    Filed: December 3, 2025
    Publication date: June 11, 2026
    Inventor: Gregory KAPP
  • Affinity reagents having enhanced binding and detection characteristics
    Patent number: 12577608
    Abstract: An affinity reagent, having: (a) a retaining component such as a structured nucleic acid particle; and (b) one or both of (i) one or more label components attached to the retaining component, and (ii) one or more binding components attached to the retaining component.
    Type: Grant
    Filed: June 2, 2023
    Date of Patent: March 17, 2026
    Assignee: Nautilus Subsidiary, Inc.
    Inventors: Tural Aksel, Torri Rinker, Markus Burns, Michael Dorwart, Rachel Galimidi, Dmitriy Gremyachinskiy, Stephen Hendricks, Elvis Ikwa, Gregory Kapp, Joshua Simon Klein, Julia Robinson, Cassandra Stawicki, Sonal Tonapi, Parag Mallick
  • SYSTEMS, METHODS AND COMPOSITIONS FOR ANALYSIS OF PROTEOFORMS
    Publication number: 20260029416
    Abstract: Methods, reagents, kits and systems for analyzing different proteoforms of proteins of interest are provided. The provided methods, systems, etc. provide detection, characterization and quantitation of proteoforms for different biologically relevant proteins for monitoring and characterizing biological processes.
    Type: Application
    Filed: July 24, 2025
    Publication date: January 29, 2026
    Inventors: Parag MALLICK, Jarrett D. EGERTSON, Gregory KAPP, Kara JUNEAU, Vivekananda BUDAMAGUNTA, Sanjib GUHA, James Henry JOLY, Steven TAN, Zhengjian ZHANG, Maryam JOUZI
  • METHODS FOR CHARACTERIZING INTERACTIONS BETWEEN ANALYTES
    Publication number: 20250306018
    Abstract: Methods and systems for identifying and/or quantifying polypeptide binding interactions of ligand-binding polypeptides are disclosed. Detailed methods include methods for identifying binding ligands of ligand-binding polypeptides and methods for assessing changes in binding behavior due to alterations of ligand-binding polypeptides. Detailed systems include array-based systems that permit detection of ligand binding interactions at single-analyte resolution.
    Type: Application
    Filed: June 11, 2025
    Publication date: October 2, 2025
    Inventors: Gregory KAPP, James Henry JOLY, James SHERMAN, Torri Elise RINKER, Raymond MAK
  • FLUIDIC DEVICES FOR SINGLE-ANALYTE ASSAYS
    Publication number: 20250205706
    Abstract: Fluidic vessels having flow-altering properties are provided. The fluidic vessels may alter fluid flow velocity profiles downstream of ports or inlets to produce a more substantially uniform flow velocity profile. Fluidic vessels provided herein may be useful for delivering and/or discharging fluidic media containing pluralities of macromolecules during fluid transfer processes.
    Type: Application
    Filed: December 18, 2024
    Publication date: June 26, 2025
    Inventors: Meysam Rezaei BARMI, Ali Najafi SOHI, Gregory KAPP, Scott RAPOPORT
  • METHODS FOR IDENTIFYING MODIFICATIONS OF A POLYPEPTIDE
    Publication number: 20250180578
    Abstract: Systems and methods for obtaining qualitative or quantitative measurements of proteoforms of polypeptides are described. The described methods include measurements of affinity reagent binding on single-molecule polypeptide arrays to distinguish between polypeptide isoforms. The described methods may provide high resolution quantitative comparisons of proteoforms with very low copy numbers.
    Type: Application
    Filed: December 3, 2024
    Publication date: June 5, 2025
    Inventors: Parag MALLICK, Jarrett D. EGERTSON, Gregory KAPP
  • SYSTEMS AND METHODS FOR BIOMOLECULE QUANTITATION
    Publication number: 20240402186
    Abstract: Systems and methods for obtaining qualitative or quantitative measurements of proteoforms of polypeptides are described. The described methods include measurements of affinity reagent binding on single-molecule polypeptide arrays to distinguish between polypeptide isoforms. The described methods may provide high resolution quantitative comparisons of proteoforms with very low copy numbers.
    Type: Application
    Filed: July 24, 2024
    Publication date: December 5, 2024
    Inventors: Mallick PARAG, Jarrett D. EGERTSON, Gregory KAPP
  • POLYMERIC FORMS OF H-NOX PROTEINS
    Publication number: 20240400648
    Abstract: The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides the use of H-NOX proteins as radiosensitizers for the treatment of brain cancers.
    Type: Application
    Filed: April 18, 2024
    Publication date: December 5, 2024
    Inventors: Gregory KAPP, Laura SERWER, Natacha LE MOAN, Stephen P.L. CARY
  • Systems and methods for biomolecule quantitation
    Patent number: 12092642
    Abstract: Systems and methods for obtaining qualitative or quantitative measurements of proteoforms of polypeptides are described. The described methods include measurements of affinity reagent binding on single-molecule polypeptide arrays to distinguish between polypeptide isoforms. The described methods may provide high resolution quantitative comparisons of proteoforms with very low copy numbers.
    Type: Grant
    Filed: January 19, 2022
    Date of Patent: September 17, 2024
    Assignee: NAUTILUS SUBSIDIARY, INC.
    Inventors: Parag Mallick, Jarrett D. Egertson, Gregory Kapp
  • Affinity reagents having enhanced binding and detection characteristics
    Patent number: 11993807
    Abstract: An affinity reagent, having: (a) a retaining component such as a structured nucleic acid particle; and (b) one or both of (i) one or more label components attached to the retaining component, and (ii) one or more binding components attached to the retaining component.
    Type: Grant
    Filed: March 7, 2023
    Date of Patent: May 28, 2024
    Assignee: Nautilus Subsidiary, Inc.
    Inventors: Tural Aksel, Torri Rinker, Markus Burns, Michael Dorwart, Rachel Galimidi, Dmitriy Gremyachinskiy, Stephen Hendricks, Elvis Ikwa, Gregory Kapp, Joshua Simon Klein, Julia Robinson, Cassandra Stawicki, Sonal Tonapi, Parag Mallick
  • Polymeric forms of H-NOX proteins
    Patent number: 11987614
    Abstract: The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides the use of H-NOX proteins as radiosensitizers for the treatment of brain cancers.
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: May 21, 2024
    Assignee: OMNIOX, INC.
    Inventors: Gregory Kapp, Laura Serwer, Natacha Le Moan, Stephen P. L. Cary
  • AFFINITY REAGENTS HAVING ENHANCED BINDING AND DETECTION CHARACTERISTICS
    Publication number: 20240018574
    Abstract: An affinity reagent, having: (a) a retaining component such as a structured nucleic acid particle; and (b) one or both of (i) one or more label components attached to the retaining component, and (ii) one or more binding components attached to the retaining component.
    Type: Application
    Filed: June 2, 2023
    Publication date: January 18, 2024
    Inventors: Tural AKSEL, Torri RINKER, Markus BURNS, Michael DORWART, Rachel GALIMIDI, Dmitriy GREMYACHINSKIY, Stephen HENDRICKS, Elvis IKWA, Gregory KAPP, Joshua Simon KLEIN, Julia ROBINSON, Cassandra STAWICKI, Sonal TONAPI, Parag MALLICK
  • AFFINITY REAGENTS HAVING ENHANCED BINDING AND DETECTION CHARACTERISTICS
    Publication number: 20230272459
    Abstract: An affinity reagent, having: (a) a retaining component such as a structured nucleic acid particle; and (b) one or both of (i) one or more label components attached to the retaining component, and (ii) one or more binding components attached to the retaining component.
    Type: Application
    Filed: March 7, 2023
    Publication date: August 31, 2023
    Inventors: Tural AKSEL, Torri RINKER, Markus BURNS, Michael DORWART, Rachel GALIMIDI, Dmitriy GREMYACHINSKIY, Stephen HENDRICKS, Elvis IKWA, Gregory KAPP, Joshua Simon KLEIN, Julia ROBINSON, Cassandra STAWICKI, Sonal TONAPI, Parag MALLICK
  • SYSTEMS AND METHODS FOR BIOMOLECULE PREPARATION
    Publication number: 20230212322
    Abstract: Methods for the preparation of sample polypeptide fractions are described. Sample polypeptides may be isolated from any of a variety of sources, including biological and non-biological systems. Sample polypeptides may be coupled or conjugated to other molecules to permit characterization of the sample polypeptide fractions. Sample polypeptide fractions may be prepared for analysis by a polypeptide assay.
    Type: Application
    Filed: March 9, 2023
    Publication date: July 6, 2023
    Inventors: Gregory KAPP, Julia ROBINSON, Parag MALLICK, Torri RINKER, Deepthi ANUMALA
  • Affinity reagents having enhanced binding and detection characteristics
    Patent number: 11692217
    Abstract: An affinity reagent, having: (a) a retaining component such as a structured nucleic acid particle; and (b) one or both of (i) one or more label components attached to the retaining component, and (ii) one or more binding components attached to the retaining component.
    Type: Grant
    Filed: November 10, 2021
    Date of Patent: July 4, 2023
    Assignee: Nautilus Subsidiary, Inc.
    Inventors: Tural Aksel, Torri Rinker, Markus Burns, Michael Dorwart, Rachel Galimidi, Dmitriy Gremyachinskiy, Stephen Hendricks, Elvis Ikwa, Gregory Kapp, Joshua Simon Klein, Julia Robinson, Cassandra Stawicki, Sonal Tonapi, Parag Mallick
  • METHODS AND SYSTEMS FOR DETERMINING POLYPEPTIDE INTERACTIONS
    Publication number: 20230090454
    Abstract: Methods and systems for identifying and/or quantifying polypeptide binding interactions of ligand-binding polypeptides are disclosed. Detailed methods include methods for identifying binding ligands of ligand-binding polypeptides and methods for assessing changes in binding behavior due to alterations of ligand-binding polypeptides. Detailed systems include array-based systems that permit detection of ligand binding interactions at single-analyte resolution.
    Type: Application
    Filed: September 19, 2022
    Publication date: March 23, 2023
    Inventors: Gregory KAPP, James Henry JOLY, James SHERMAN, Torri Elise RINKER, Raymond MAK
  • METHODS AND SYSTEMS FOR ASSAY REFINEMENT
    Publication number: 20220412998
    Abstract: Methods for performing procedures on single analytes at single-analyte resolution are disclosed. The methods utilize an iterative approach to performing a sequence of steps during a single-analyte process. Control of the single-analyte process is achieved by implementing actions during each iteration based upon one or more determined process metrics. Systems are also detailed for implementing the disclosed methods at single-analyte resolution.
    Type: Application
    Filed: June 23, 2022
    Publication date: December 29, 2022
    Inventors: Vadim LOBANOV, Jarrett EGERTSON, Shunqiang WANG, Pierre INDERMUHLE, Gregory KAPP, Ryan SEGHERS, Siavash YOUSEFI
  • SYSTEMS AND METHODS FOR BIOMOLECULE QUANTITATION
    Publication number: 20220236282
    Abstract: Systems and methods for obtaining qualitative or quantitative measurements of proteoforms of polypeptides are described. The described methods include measurements of affinity reagent binding on single-molecule polypeptide arrays to distinguish between polypeptide isoforms. The described methods may provide high resolution quantitative comparisons of proteoforms with very low copy numbers.
    Type: Application
    Filed: January 19, 2022
    Publication date: July 28, 2022
    Inventors: Parag MALLICK, Jarrett D. EGERTSON, Gregory KAPP
  • SYSTEMS AND METHODS FOR BIOMOLECULE PREPARATION
    Publication number: 20220227890
    Abstract: Methods for the preparation of sample polypeptide fractions are described. Sample polypeptides may be isolated from any of a variety of sources, including biological and non-biological systems. Sample polypeptides may be coupled or conjugated to other molecules to permit characterization of the sample polypeptide fractions. Sample polypeptide fractions may be prepared for analysis by a polypeptide assay.
    Type: Application
    Filed: January 21, 2022
    Publication date: July 21, 2022
    Inventors: Gregory Kapp, Julia Robinson, Parag Mallick, Torri Rinker, Deepthi Anumala
  • AFFINITY REAGENTS HAVING ENHANCED BINDING AND DETECTION CHARACTERISTICS
    Publication number: 20220162684
    Abstract: An affinity reagent, having: (a) a retaining component such as a structured nucleic acid particle; and (b) one or both of (i) one or more label components attached to the retaining component, and (ii) one or more binding components attached to the retaining component.
    Type: Application
    Filed: November 10, 2021
    Publication date: May 26, 2022
    Inventors: Tural AKSEL, Torri RINKER, Markus BURNS, Michael DORWART, Rachel GALIMIDI, Dmitriy GREMYACHINSKIY, Stephen HENDRICKS, Elvis IKWA, Gregory KAPP, Joshua KLEIN, Julia ROBINSON, Cassandra STAWICKI, Sonal TONAPI, Parag MALLICK