Abstract: The invention relates to a drug delivery system for contraception including a steroidal estrogenic compound, a steroidal progestogenic compound or a combination thereof for the purposes of contraception in a subject, and provides for an ultra-low dose delivery of a steroidal estrogenic compound which minimizes or eliminates a burst release effect. The invention also relates to a method of contraception using the drug delivery system and method of manufacturing the drug delivery system.

Abstract: The invention relates to a drug delivery system for contraception including a steroidal estrogenic compound, a steroidal progestogenic compound or a combination thereof for the purposes of contraception in a subject, and provides for an ultra-low dose delivery of a steroidal estrogenic compound which minimizes or eliminates a burst release effect. The invention also relates to a method of contraception using the drug delivery system and method of manufacturing the drug delivery system.

Abstract: Systems and methods for simulating cyber-physical systems are disclosed. A plurality of geographic simulation layers representing respective infrastructure sectors of a real-world environment may be generated, and the layers may be linked together with one another to create a multi-layer simulation. The associations between the layers of the simulation may be adjusted, and characteristics of the simulation layers themselves may be adjusted, to ensure that the simulation conforms to characteristics of the real-world environment being simulated. In some embodiments, a multi-user simulation system allows users at separate terminals to execute attack inputs and defense inputs against the simulation to try to destabilize and stabilize the simulation, respectively. Results of the attack inputs and defense inputs may be simultaneously displayed on a plurality of terminals.

Abstract: The invention described herein provides new combination products for the cyclical provision of a methylcobalamin compound and a steroid compound in a dosing regimen wherein the total amount of methylcobalamin administered during any one treatment cycle does not exceed 35 mcg. More specifically, the combination products described in this disclosure promote the prevention or treatment of a vitamin B12 deficiency, support the replenishment and or maintenance of healthy blood cell levels, or both, particularly in those experiencing a periodic physiological challenge which may compromise vitamin B12 status or result in an increased requirement for vitamin B12, such as the monthly blood loss experienced by a reproductively cycling human female.

Abstract: Systems and methods for simulating cyber-physical systems are disclosed. A plurality of geographic simulation layers representing respective infrastructure sectors of a real-world environment may be generated, and the layers may be linked together with one another to create a multi-layer simulation. The associations between the layers of the simulation may be adjusted, and characteristics of the simulation layers themselves may be adjusted, to ensure that the simulation conforms to characteristics of the real-world environment being simulated. In some embodiments, a multi-user simulation system allows users at separate terminals to execute attack inputs and defense inputs against the simulation to try to destabilize and stabilize the simulation, respectively. Results of the attack inputs and defense inputs may be simultaneously displayed on a plurality of terminals.

Abstract: The invention described herein provides new methods and compositions for the cyclical provision of a vitamin B12 compound in a dosing regimen wherein the total amount of vitamin B12 administered during any one treatment cycle does not exceed 35 mcg. More specifically, the invention described in this disclosure promotes the prevention or treatment of a vitamin B12 deficiency, supports the replenishment and or maintenance of healthy blood cell levels, or both, particularly in those experiencing a periodic physiological challenge which may compromise vitamin B12 status or result in an increased requirement for vitamin B12, such as the monthly blood loss experienced by a reproductively cycling human female.

Abstract: Method of treating or preventing trichomoniasis or T. vaginalis infection in a subject in need thereof, the method involving administering to the subject a therapeutically effective amount of secnidazole or a pharmaceutically acceptable salt in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules. The subject can also have bacterial vaginosis, is HIV-positive, and/or is suffering with metronidazole-resistant trichomoniasis and/or tinidazole-resistant trichomoniasis. The subject can also be a sexual partner of a person with trichomoniasis. The microgranule formulation can also be administered with paromomycin, tinidazole, metronidazole, boric acid or a combination thereof. Pharmaceutical compositions and uses for treating or preventing trichomoniasis or T. vaginalis infection in a subject in need thereof are also contemplated herein.

Abstract: The invention described herein provides new methods and compositions for the cyclical provision of a vitamin B12 compound in a dosing regimen wherein the total amount of vitamin B12 administered during any one treatment cycle does not exceed 35 mcg. More specifically, the invention described in this disclosure promotes the prevention or treatment of a vitamin B12 deficiency, supports the replenishment and or maintenance of healthy blood cell levels, or both, particularly in those experiencing a periodic physiological challenge which may compromise vitamin B12 status or result in an increased requirement for vitamin B12, such as the monthly blood loss experienced by a reproductively cycling human female.

Abstract: A soft gelatin capsule composition for vaginal administration of secnidazole includes a therapeutically effective amount of secnidazole dispersed in a pharmaceutically acceptable carrier. The therapeutically effective amount of secnidazole is in a range of from about 1 mg to about 500 mg, or in a range of from about 1,000 mg to about 1,500 mg. The composition is used for treating diseases, including bacterial vaginosis or trichomoniasis.

Abstract: The invention relates to a drug delivery system for contraception including a steroidal estrogenic compound, a steroidal progestogenic compound or a combination thereof for the purposes of contraception in a subject, and provides for an ultra-low dose delivery of a steroidal estrogenic compound. The invention also relates to a method of contraception using the drug delivery system and method of manufacturing the drug delivery system.

Abstract: A two handled shovel for clearing a surface, the shovel comprising a blade having a leading edge which contacts the surface, a main handle attached to the blade, and an auxiliary handle pivotally attached to the blade near the leading edge. The shovel may be used by one or two users.

Abstract: A tire chain assembly for enhancing tire traction is provided. The assembly does not require the car to be moved or placed on a jack to be installed. The tire chain assembly comprises a pair of parallel nylon straps connected by nylon cross straps bearing rivets or spikes to provide traction. A metal chain is permanently connected to a first cross strap by a cleat, extends through a series of hollow, cylindrical guides on each cross strap and terminates in a clip or other fastening means at the free end of the chain. Mushroom shaped cleats located at the other end of each cross strap are used to secure the tire chain assembly to the tire.

Abstract: A two handled shovel for clearing a surface, the shovel comprising a blade having a leading edge which contacts the surface, a main handle attached to the blade, and an auxiliary handle pivotally attached to the blade near the leading edge. The shovel may be used by one or two users.