Patents by Inventor Gregory L. Heinkel

Gregory L. Heinkel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of modified tethers in screening compound libraries
    Patent number: 6309842
    Abstract: The invention provides methods for screening libraries of complexes for compounds having a desired property, especially, the capacity to agonize, bind to, or antagonize a cellular receptor. The complexes in such libraries comprise a compound under test, a tag recording at least one step in synthesis of the compound, and a tether susceptible to modification by a reporter molecule. Modification of the tether is used to signify that a complex contains a compound having a desired property. The tag can be decoded to reveal at least one step in the synthesis of such a compound.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: October 30, 2001
    Assignee: Glaxo Wellcome Inc.
    Inventors: William J. Dower, Christian M. Gates, Gregory L. Heinkel, Guy Lalonde, Larry C. Mattheakis, Christopher J. Paddon, Peter J. Schatz
  • Use of modified tethers in screening compound libraries
    Patent number: 5958703
    Abstract: The invention provides methods for screening libraries of complexes for compounds having a desired property, especially, the capacity to agonize, bind to, or antagonize a cellular receptor. The complexes in such libraries comprise a compound under test, a tag recording at least one step in synthesis of the compound, and a tether susceptible to modification by a reporter molecule. Modification of the tether is used to signify that a complex contains a compound having a desired property. The tag can be decoded to reveal at least one step in the synthesis of such a compound.
    Type: Grant
    Filed: December 3, 1996
    Date of Patent: September 28, 1999
    Assignee: Glaxo Group Limited
    Inventors: William J. Dower, Gregory L. Heinkel, Larry Mattheakis, Peter J. Schatz