Patents by Inventor Gregory L. Helms

Gregory L. Helms has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiparasitic agents
    Patent number: 5614546
    Abstract: There are disclosed novel compounds which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal gents.
    Type: Grant
    Filed: December 20, 1994
    Date of Patent: March 25, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Anne W. Dombrowski, Richard G. Endris, Gregory L. Helms, Otto D. Hensens, John G. Ondeyka, Dan A. Ostlind, Jon D. Polishook, Deborah L. Zink
  • Antiparasitic agents
    Patent number: 5399582
    Abstract: There are disclosed novel compounds which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal gents.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: March 21, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Anne W. Dombrowski, Richard G. Endris, Gregory L. Helms, Otto D. Hensens, John G. Ondeyka, Dan A. Ostlind, Jon D. Polishook, Deborah L. Zink
  • Antifungal compound and compositions containing the compound
    Patent number: 5348970
    Abstract: A compound of the formula 1: ##STR1## is produced via fermentation of a fungal isolate ATCC no. 74235. The organism is included herein, as well as a process for production of the compound, a pharmaceutical composition and a method of treatment.
    Type: Grant
    Filed: September 22, 1993
    Date of Patent: September 20, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Robert E. Schwartz, Janet C. Onishi, Gerald F. Bills, Robert A. Giacobbe, Fernando Pelaez, Maria T. Diez, Francisca Vicente, Julian Gorrochategui, Gregory L. Helms, Barnali Pramanik
  • Anthelmintic milbemycin analogs of novel microorganisms
    Patent number: 5290804
    Abstract: There is disclosed a series of macrolides isolated from the fermentation broth of microorganisms identified as MA-6825, MA-6864 and MA-6865. The structure of the novel compounds isolated from the microorganisms is presented based upon analytical studies. The compounds are highly potent antiparasitic, insecticidal, and anthelmintic agents and are related to the class of macrolides known as milbemycins. Compositions for such uses are also disclosed.
    Type: Grant
    Filed: April 13, 1992
    Date of Patent: March 1, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Robert T. Goegelman, Elvira Munguira, Maria T. Diez Matas, Ruth S. Sykes, Yu L. Kong, Jerrold M. Liesch, Gregory L. Helms, E. Tracy Turner Jones
  • Antibiotic agents
    Patent number: 5276055
    Abstract: Compounds having the formula ##STR1## wherein R and R.sup.1 may be H or COCH.sub.3 provided that when R.sup.1 is COCH.sub.3, R is COCH.sub.3 are described.
    Type: Grant
    Filed: October 19, 1992
    Date of Patent: January 4, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Angeles Cabello, Guy Harris, Robert A. Giacobbe, Gregory L. Helms, Otto D. Hensens, Suzanne M. Mandala, E. Tracy T. Jones, Isabel Martin, Walter Rozdilsky
  • Cholesterol lowering agents
    Patent number: 5182298
    Abstract: This invention relates to compounds of structural formula (I) ##STR1## which are useful as Cholestrol lowering agents.
    Type: Grant
    Filed: March 18, 1991
    Date of Patent: January 26, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Gregory L. Helms, Wendy S. Horn, E. Tracy T. Jones, David L. Linemeyer