Patents by Inventor Gregory Lawrence LACKNER

Gregory Lawrence LACKNER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KRAS G12C INHIBITORS
    Publication number: 20240025916
    Abstract: The present disclosure provides compounds of the formula: where R1, R2, R3, R4, R5, A, and B are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and salts for treating patients for cancer.
    Type: Application
    Filed: November 24, 2021
    Publication date: January 25, 2024
    Inventors: David Michael HYMAN, Gregory Lawrence LACKNER, Sheng-Bin PENG, Bree Leigh RICHEY, Chong SI
  • Phenyl-3,4-dihydroisoquinolin-2(1h)-yl-ethan-1-one derivatives as dopamine d1receptor positive allosteric modulators
    Publication number: 20230382869
    Abstract: The invention provides certain (phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one related compounds of formula I as D1 positive allosteric modulators (PAMs), and pharmaceutical compositions thereof. The invention further provides methods of using a compound of formula I, to treat certain symptoms of dopaminergic CNS disorders including Parkinson's disease, Schizophrenia, ADHD or Alzheimer's disease.
    Type: Application
    Filed: October 5, 2021
    Publication date: November 30, 2023
    Inventors: Junliang HAO, Richard D. JOHNSTON, Gregory Lawrence LACKNER, Erik J. HEMBRE, Kjell A. SVENSSON
  • NOVEL RNA THERAPEUTICS AND USES THEREOF
    Publication number: 20230022590
    Abstract: The present disclosure relates to novel RNAi agents designed to decrease the expression of ANGPTL8 in the liver, where the RNAi agents comprise delivery moieties conjugated to oligonucleotides optionally via a linker. The RNAi agents are useful in the treatment of diseases involving the regulation of ANGPTL8 expression.
    Type: Application
    Filed: June 22, 2022
    Publication date: January 26, 2023
    Inventors: Rebecca Ruth MILES, Jibo WANG, Melissa Ann BELLINGER, Thomas Patrick BEYER, Christine Chih-Tao CHENG, MariJean EGGEN, Gregory Lawrence LACKNER