Patents by Inventor Gregory Lazar

Gregory Lazar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fc Variants Having Increased Affinity for FcyRllla
    Publication number: 20070237766
    Abstract: The present invention relates to Fc variants having increased affinity for Fc?RIIIa, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: June 19, 2007
    Publication date: October 11, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • Fc Variants Having Increased Affinity for FcyRIIb
    Publication number: 20070231329
    Abstract: The present invention relates to Fc variants having increased affinity for Fc?RIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: June 15, 2007
    Publication date: October 4, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • CD20 OPTIMIZED Fc VARIANTS AND METHODS FOR THEIR GENERATION
    Publication number: 20070224189
    Abstract: The present invention relates to CD20 optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: December 29, 2006
    Publication date: September 27, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Arthur Chirino, Wei Dang, John Desjarlais, Stephen Doberstein, Robert Hayes, Sher Karki, Omid Vafa
  • OPTIMIZED Fc VARIANTS AND METHODS FOR THEIR GENERATION
    Publication number: 20070224192
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: May 11, 2007
    Publication date: September 27, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Arthur Chirino, Wei Dang, John Desjarlais, Stephen Doberstein, Robert Hayes, Sher Karki, Omid Vafa
  • CD52 OPTIMIZED Fc VARIANTS AND METHODS FOR THEIR GENERATION
    Publication number: 20070219133
    Abstract: The present invention relates to CD52 optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: December 29, 2006
    Publication date: September 20, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Arthur Chirino, Wei Dang, John Desjarlais, Stephen Doberstein, Robert Hayes, Sher Karki, Omid Vafa
  • Her2/neu OPTIMIZED Fc VARIANTS AND METHODS FOR THEIR GENERATION
    Publication number: 20070202098
    Abstract: The present invention relates to Her2/neu optimized Sc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: December 29, 2006
    Publication date: August 30, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Arthur Chirino, Wei Dang, John Desjarlais, Stephen Doberstein, Robert Hayes, Sher Karki, Omid Vafa
  • OPTIMIZED ANTI-CD30 ANTIBODIES
    Publication number: 20070166309
    Abstract: An antibody that targets CD30, wherein the antibody comprises at least one modification relative to a parent antibody and the antibody binds with altered affinity to an Fc?R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the anti-CD30 antibody.
    Type: Application
    Filed: March 15, 2007
    Publication date: July 19, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, John Desjarlais, Philip Hammond, David Carmichael, Bao-lu Chen, Seung Chu, Sher Karki
  • Optimized Fc variants and methods for their generation
    Publication number: 20070160597
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: July 7, 2006
    Publication date: July 12, 2007
    Inventors: Gregory Lazar, Arthur Chirino, Wei Dang, John Desjarlais, Stephen Doberstein, Robert Hayes, Sher Karki, Omid Vafa
  • Server identification in storage networks
    Publication number: 20070156877
    Abstract: Described are techniques for providing a host identifier for a host. A first portion including a first identifier associated with a system image for the host is received. A second portion including a second identifier generated in accordance with a hardware property of said host is received. The host identifier is formed using the first and second portions. The host identifier is used to uniquely identify said host in a storage area network.
    Type: Application
    Filed: January 3, 2006
    Publication date: July 5, 2007
    Inventors: Sriram Krishnan, Andreas Bauer, Russell Laporte, Gregory Lazar
  • Fc Variants With Optimized Fc Receptor Binding Properties
    Publication number: 20070148170
    Abstract: The present invention relates to Fc variants with optimized Fc receptor binding properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized Fc receptor binding properties, and methods for using Fc variants with optimized Fc receptor binding properties.
    Type: Application
    Filed: October 3, 2006
    Publication date: June 28, 2007
    Inventors: John Desjarlais, Sher Karki, Gregory Lazar, John Richards, Gregory Moore, David Carmichael
  • Optimized anti-CD30 antibodies
    Publication number: 20070148171
    Abstract: An antibody that targets CD30, wherein the antibody comprises at least one modification relative to a parent antibody and the antibody binds with altered affinity to an Fc?R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the anti-CD30 antibody.
    Type: Application
    Filed: October 6, 2006
    Publication date: June 28, 2007
    Applicant: XENCOR, INC.
    Inventors: Gregory Lazar, John Desjarlais, Philip Hammond, David Carmichael, Bao-lu Chen, Seung Chu, Sher Karki
  • Fc variants with altered binding to FcRn
    Publication number: 20070135620
    Abstract: The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes.
    Type: Application
    Filed: May 17, 2006
    Publication date: June 14, 2007
    Inventors: Aaron Chamberlain, John Desjarlais, Sher Karki, Gregory Lazar, Jost Vielmetter, Sean Yoder
  • Optimized proteins that target Ep-CAM
    Publication number: 20070122406
    Abstract: Humanized Ep-CAM-targeting antibodies and methods of making and using the same are provided.
    Type: Application
    Filed: July 10, 2006
    Publication date: May 31, 2007
    Inventors: Aaron Chamberlain, John Desjarlais, Gregory Lazar
  • Anti-glypican-3 antibody
    Publication number: 20070087005
    Abstract: An anti-glypican-3 antibody comprising one or more amino acid substitutions introduced in the Fc region is disclosed. Preferably, in the anti-glypican-3 antibody, one or more of the amino acid residues at the positions 239, 298, 326, 330 and 332 in the Fc region are substituted with other amino acid residues. Since the Fc-modified anti-glypican-3 antibody of the invention exhibit enhanced ADCC activity, it is useful in treating cancers, such as hepatic cancer. Also disclosed are an anticancer agent comprising the anti-glypican-3 antibody of the invention and a pharmaceutically acceptable carrier, as well as a method of treating a patient with cancer comprising administering to the patient the anticancer agent of the invention.
    Type: Application
    Filed: October 14, 2005
    Publication date: April 19, 2007
    Inventors: Gregory Lazar, Bassil Dahiyat, Hisafumi Okabe, Masamichi Sugimoto, Shigeyuki Iijima, Izumi Sugo
  • Optimized Fc variants and methods for their generation
    Publication number: 20070053901
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: July 27, 2006
    Publication date: March 8, 2007
    Inventors: Gregory Lazar, Arthur Chirino, Wei Dang, John Desjarlais, Stephen Doberstein, Robert Hayes, Sher Karki, Omid Vafa
  • Optimized Fc variants and methods for their generation
    Publication number: 20070003546
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: July 7, 2006
    Publication date: January 4, 2007
    Inventors: Gregory Lazar, Arthur Chirino, Wei Dang, John Desjarlais, Stephen Doberstein, Robert Hayes, Sher Karki, Omid Vafa
  • Fc variants with optimized properties
    Publication number: 20060235208
    Abstract: The present invention relates to Fc variants with optimized properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized properties, and methods for using Fc variants with optimized properties.
    Type: Application
    Filed: March 31, 2006
    Publication date: October 19, 2006
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki
  • Fc variants with altered binding to FcRn
    Publication number: 20060173170
    Abstract: The present application relates to optimized IgG immunoglobulin engineering methods for their generation, and their application, particularly for therapeutic purposes.
    Type: Application
    Filed: November 14, 2005
    Publication date: August 3, 2006
    Inventors: Aaron Chamberlain, John Desjarlais, Sher Karki, Gregory Lazar, Jost Vielmetter, Sean Yoder
  • Optimized Fc variants and methods for their generation
    Publication number: 20060160996
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: March 26, 2004
    Publication date: July 20, 2006
    Inventors: Gregory Lazar, Arthur Chirino, Wei Dang, John Desjarlais, Stephen Doberstein, Robert Hayes, Sher Karki, Omid Vafa
  • IgG immunoglobulin variants with optimized effector function
    Publication number: 20060134105
    Abstract: The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes.
    Type: Application
    Filed: October 21, 2005
    Publication date: June 22, 2006
    Inventors: Gregory Lazar, Bassil Dahiyat, Wei Dang, Sher Karki, Omid Vafa