Abstract: A sheath-bonding link box is provided, the sheath-bonding link box including a housing defining a sealed interior space, and a set of electrically conductive connectors extending through the housing between an exterior of the enclosure and the interior space. The set of connectors each has an internal portion positioned inside of the interior space and an external portion positioned outside of the housing. The internal portion of the connectors is electrically connectable to a functional link in the interior space, and the external portion of the connectors is dimensioned to be electrically connectable to a sheath-bonding lead.

Abstract: A system and method for monitoring moisture at a structural component having a membrane for fluid impermeability and a deck for supporting the membrane at a first side of the membrane opposite a second side of the membrane is provided. The system includes: (a) a plurality of sensors spaced apart from each other adjacent to the membrane at the second side, the plurality of sensors including one or more wireless sensors, each of the sensors including a plurality of sensor conductors and a connection member connecting the plurality of sensor conductors to each other while electrically insulating the sensor conductors from each other; and (b) a controller operable to selectively communicate wirelessly with each of the wireless sensors, and operable to selectively determine a sensor output from each of the sensors. The method involves measuring resistance for longterm tracking of pooling of an electrically conductive fluid on the structural component.

Abstract: Systems and methods for treating tissue may include one or more delivery devices, a grasping element, a first ring for anchoring to a wall of a gastrointestinal tract, and a second ring operably couplable to a radially inward surface of the first ring. Other embodiments include methods of treating tissues, including tubular tracts of tissue, comprising coupling a first ring to first tissue of a wall of a tissue tract, relocating a target tissue proximally to a position proximal to the first ring, coupling a second ring to the first ring, and cutting tissue proximal to the interface of the first and second rings.

Abstract: A sheath-bonding link box is provided, the sheath-bonding link box including a housing defining a sealed interior space, and a set of electrically conductive connectors extending through the housing between an exterior of the enclosure and the interior space. The set of connectors each has an internal portion positioned inside of the interior space and an external portion positioned outside of the housing. The internal portion of the connectors is electrically connectable to a functional link in the interior space, and the external portion of the connectors is dimensioned to be electrically connectable to a sheath-bonding lead.

Abstract: A pressure sensing medical device may include a guidewire including a tubular member having a lumen, the tubular member being translatable between a generally straightened position and a deflected position, and a pressure sensor attached at a distal end of a fiber optic extending within the lumen, the pressure sensor being disposed within a distal portion of the tubular member. The pressure sensor may include a pressure-sensitive membrane disposed on a distal end thereof. The pressure sensor may include one or more contact members capable of providing a contact point between the contact member and an inner surface of the tubular member when in the deflected position, the contact point being axially spaced apart from the membrane along a longitudinal axis of the pressure sensor.

Abstract: An antibody-based GnRH receptor antagonist and methods of making and using same are disclosed. The antibody-based GnRH receptor antagonist is a GHR-106 monoclonal antibody (GHR-106) or an antigen-binding fragment thereof. GHR-106 or its IgG fragments can be utilized for therapeutic applications in the treatment of cancer and a range of sex hormone-related disorders or conditions in male or female subjects for which decapeptide GnRH antagonists are currently used.

Abstract: An antibody-based GnRH receptor antagonist and methods of making and using same are disclosed. The antibody-based GnRH receptor antagonist is a GHR-106 monoclonal antibody (GHR-106) or an antigen-binding fragment thereof. GHR-106 or its IgG fragments can be utilized for therapeutic applications in the treatment of cancer and a range of sex hormone-related disorders or conditions in male or female subjects for which decapeptide GnRH antagonists are currently used.

Abstract: A sheath-bonding link box is provided, the sheath-bonding link box including a housing defining a sealed interior space, and a set of electrically conductive connectors extending through the housing between an exterior of the enclosure and the interior space. The set of connectors each has an internal portion positioned inside of the interior space and an external portion positioned outside of the housing. The internal portion of the connectors is electrically connectable to a functional link in the interior space, and the external portion of the connectors is dimensioned to be electrically connectable to a sheath-bonding lead.

Abstract: Systems and methods for treating tissue may include one or more delivery devices, a grasping element, a first ring for anchoring to a wall of a gastrointestinal tract, and a second ring operably couplable to a radially inward surface of the first ring. Other embodiments include methods of treating tissues, including tubular tracts of tissue, comprising coupling a first ring to first tissue of a wall of a tissue tract, relocating a target tissue proximally to a position proximal to the first ring, coupling a second ring to the first ring, and cutting tissue proximal to the interface of the first and second rings.

Abstract: A network testing system includes a test station and a communication device running an application. A VNC client and a VNC server are provided on the communication device to control the application for network testing purposes. In operation, the test station communicates with the remote VNC client, providing information and context data for the network test. More than one communication device may be used in the test.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a medical device for measuring blood pressure. The medical device may include an elongated shaft having a proximal region and a distal region. An optical fiber may extend along the proximal region. An optical pressure sensor may be coupled to the optical fiber. The medical device may also include a tubular member having a proximal end disposed adjacent to the optical pressure sensor and a distal portion extending along the distal region of the shaft.

Abstract: Pressure sensing guidewires and methods for making and using pressure sensing guidewires are disclosed. An example pressure sensing guidewire may include a tubular member having a proximal region and a housing region. A pressure sensor may be disposed within the housing region. A signal transmitting member may be coupled to the pressure sensor and extending proximally therefrom. A hydrophilic coating may be disposed along an inner surface of the housing region.

Abstract: A personal safety glove including a glove having a top surface, a bottom surface, and an adjustable cuff. A camera, a speaker, an activation control, a charging port, an emergency control, and an indicator light are disposed on the glove. A rechargeable battery, a GPS tracking chip, and a microprocessor are disposed within the glove. The emergency control has a first position, an alternate second position, and an alternate third position. The emergency control is configured to activate the speaker to sound an alarm when the emergency control is in the first position. The emergency control is configured to activate the camera when the emergency control is in the second position. The emergency control is configured to activate the GPS tracking chip when the emergency control is in the third position.

Abstract: Humanized forms of murine GHR106 monoclonal antibodies and methods of using them are described. Humanized GHR106 monoclonal antibodies have high affinity and specificity to the corresponding tumor-associated antigen, gonadotropin-releasing hormone (GnRH) receptor comparable to murine GHR106.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a medical device for measuring blood pressure. The medical device may include an elongated shaft having a proximal region and a distal region. An optical fiber may extend along the proximal region. An optical pressure sensor may be coupled to the optical fiber. The medical device may also include a tubular member having a proximal end disposed adjacent to the optical pressure sensor and a distal portion extending along the distal region of the shaft.

Abstract: Provided herein are humanized forms of murine RP215 monoclonal antibodies and methods of using the same. These humanized RP215 monoclonal antibodies were characterized in terms of their respective affinity and specificity to the corresponding tumor-associated antigen, CA215, and shown to be comparable to those of murine RP215.

Abstract: A network testing system includes a test station and a communication device running an application. A VNC client and a VNC server are provided on the communication device to control the application for network testing purposes. In operation, the test station communicates with the remote VNC client, providing information and context data for the network test. More than one communication device may be used in the test.

Abstract: Provided herein are humanized forms of murine RP215 monoclonal antibodies and methods of using the same. These humanized RP215 monoclonal antibodies were characterized in terms of their respective affinity and specificity to the corresponding tumor-associated antigen, CA215, and shown to be comparable to those of murine RP215.

Abstract: A pressure sensing medical device may include a guidewire including a tubular member having a lumen, the tubular member being translatable between a generally straightened position and a deflected position, and a pressure sensor attached at a distal end of a fiber optic extending within the lumen, the pressure sensor being disposed within a distal portion of the tubular member. The pressure sensor may include a pressure-sensitive membrane disposed on a distal end thereof. The pressure sensor may include one or more contact members capable of providing a contact point between the contact member and an inner surface of the tubular member when in the deflected position, the contact point being axially spaced apart from the membrane along a longitudinal axis of the pressure sensor.

Abstract: Humanized forms of murine GHR106 monoclonal antibodies and methods of using them are described. Humanized GHR106 monoclonal antibodies have high affinity and specificity to the corresponding tumor-associated antigen, gonadotropin-releasing hormone (GnRH) receptor comparable to murine GHR106.