Patents by Inventor Gregory Loney

Gregory Loney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12037635
    Abstract: A method includes coupling a molecular diagnostic test device to a power source. A biological sample is conveyed into a sample preparation module. The device is then actuated by only a single action to cause the device to perform the following functions without further user action. First, the device heats the sample via a heater of the sample preparation module to lyse a portion of the sample. Second, the device conveys the lysed sample to an amplification module and heats the sample within a reaction volume of the amplification module to amplify a nucleic acid thereby producing an output solution containing a target amplicon. The device then reacts, within a detection module, each of (i) the output solution and (ii) a reagent formulated to produce a signal that indicates a presence of the target amplicon within the output solution. A result associated with the signal is then read.
    Type: Grant
    Filed: October 22, 2021
    Date of Patent: July 16, 2024
    Assignee: Visby Medical, Inc.
    Inventors: Boris Andreyev, Victor Briones, Ryan T. Cena, Adam De La Zerda, Colin Kelly, Gregory Loney, Gary Schoolnik, David Swenson
  • Patent number: 11529633
    Abstract: An apparatus includes a substrate, a first heating element, and a second heating element. The substrate includes a first portion, a second portion, and a third portion that is between the first portion and the second portion. The first portion is characterized by a first thermal conductivity, the second portion is characterized by a second thermal conductivity, and the third portion is characterized by a third thermal conductivity. The third thermal conductivity is less than the first thermal conductivity and the second thermal conductivity. The first heating element is coupled to the first portion of the substrate, and is configured to produce a first thermal output. The second heating element is coupled to the second portion of the substrate, and configured to produce a second thermal output. The second thermal output is different from the first thermal output.
    Type: Grant
    Filed: May 25, 2021
    Date of Patent: December 20, 2022
    Assignee: Visby Medical, Inc.
    Inventors: Boris Andreyev, Brian Ciopyk, Victor Briones, Jonathan Hong, David Swenson, Gregory Loney, Adam De La Zerda, Steven Chu
  • Patent number: 11273443
    Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.
    Type: Grant
    Filed: October 14, 2020
    Date of Patent: March 15, 2022
    Assignee: Visby Medical, Inc.
    Inventors: Boris Andreyev, Keith E. Moravick, Brian Ciopyk, Victor Briones, Gregory Loney, Adam De La Zerda, Jesus Ching, Steven Chu, David Swenson, Helen Huang, Colin Kelly
  • Publication number: 20220055032
    Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.
    Type: Application
    Filed: October 22, 2021
    Publication date: February 24, 2022
    Applicant: Visby Medical, Inc.
    Inventors: Boris ANDREYEV, Keith E. MORAVICK, Brian CIOPYK, Victor BRIONES, Gregory LONEY, Adam DE LA ZERDA, Jesus CHING, Steven CHU, David SWENSON, Helen HUANG, Colin KELLY
  • Publication number: 20220042076
    Abstract: A method includes coupling a molecular diagnostic test device to a power source. A biological sample is conveyed into a sample preparation module. The device is then actuated by only a single action to cause the device to perform the following functions without further user action. First, the device heats the sample via a heater of the sample preparation module to lyse a portion of the sample. Second, the device conveys the lysed sample to an amplification module and heats the sample within a reaction volume of the amplification module to amplify a nucleic acid thereby producing an output solution containing a target amplicon. The device then reacts, within a detection module, each of (i) the output solution and (ii) a reagent formulated to produce a signal that indicates a presence of the target amplicon within the output solution. A result associated with the signal is then read.
    Type: Application
    Filed: October 22, 2021
    Publication date: February 10, 2022
    Applicant: Visby Medical, Inc.
    Inventors: Boris ANDREYEV, Victor BRIONES, Ryan T. CENA, Adam DE LA ZERDA, Colin KELLY, Gregory LONEY, Gary SCHOOLNIK, David SWENSON
  • Publication number: 20210354131
    Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.
    Type: Application
    Filed: September 11, 2020
    Publication date: November 18, 2021
    Applicant: Visby Medical, Inc.
    Inventors: Boris ANDREYEV, Keith E. MORAVICK, Brian CIOPYK, Victor BRIONES, Gregory LONEY, Adam DE LA ZERDA, Jesus CHING, Steven CHU, David SWENSON, Helen HUANG, Colin KELLY
  • Publication number: 20210354132
    Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.
    Type: Application
    Filed: October 14, 2020
    Publication date: November 18, 2021
    Applicant: Visby Medical, Inc.
    Inventors: Boris ANDREYEV, Keith E. MORAVICK, Brian CIOPYK, Victor BRIONES, Gregory LONEY, Adam DE LA ZERDA, Jesus CHING, Steven CHU, David SWENSON, Helen HUANG, Colin KELLY
  • Patent number: 11168354
    Abstract: A method includes coupling a molecular diagnostic test device to a power source. A biological sample is conveyed into a sample preparation module. The device is then actuated by only a single action to cause the device to perform the following functions without further user action. First, the device heats the sample via a heater of the sample preparation module to lyse a portion of the sample. Second, the device conveys the lysed sample to an amplification module and heats the sample within a reaction volume of the amplification module to amplify a nucleic acid thereby producing an output solution containing a target amplicon. The device then reacts, within a detection module, each of (i) the output solution and (ii) a reagent formulated to produce a signal that indicates a presence of the target amplicon within the output solution. A result associated with the signal is then read.
    Type: Grant
    Filed: November 9, 2020
    Date of Patent: November 9, 2021
    Assignee: Visby Medical, Inc.
    Inventors: Boris Andreyev, Victor Briones, Ryan T. Cena, Adam De La Zerda, Colin Kelly, Gregory Loney, Gary Schoolnik, David Swenson
  • Patent number: 11167285
    Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: November 9, 2021
    Assignee: Visby Medical, Inc.
    Inventors: Boris Andreyev, Keith E. Moravick, Brian Ciopyk, Victor Briones, Gregory Loney, Adam De La Zerda, Jesus Ching, Steven Chu, David Swenson, Helen Huang, Colin Kelly
  • Patent number: 11162130
    Abstract: A method includes coupling a molecular diagnostic test device to a power source. A biological sample is conveyed into a sample preparation module. The device is then actuated by only a single action to cause the device to perform the following functions without further user action. First, the device heats the sample via a heater of the sample preparation module to lyse a portion of the sample. Second, the device conveys the lysed sample to an amplification module and heats the sample within a reaction volume of the amplification module to amplify a nucleic acid thereby producing an output solution containing a target amplicon. The device then reacts, within a detection module, each of (i) the output solution and (ii) a reagent formulated to produce a signal that indicates a presence of the target amplicon within the output solution. A result associated with the signal is then read.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: November 2, 2021
    Assignee: Visby Medical, Inc.
    Inventors: Boris Andreyev, Victor Briones, Ryan T. Cena, Adam De La Zerda, Colin Kelly, Gregory Loney, Gary Schoolnik, David Swenson
  • Publication number: 20210331159
    Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.
    Type: Application
    Filed: August 23, 2018
    Publication date: October 28, 2021
    Applicant: Visby Medical, Inc.
    Inventors: Boris ANDREYEV, Keith E. MORAVICK, Brian CIOPYK, Victor BRIONES, Gregory LONEY, Adam DE LA ZERDA, Jesus CHING, Steven CHU, David SWENSON, Helen HUANG, Colin KELLY
  • Publication number: 20210283616
    Abstract: An apparatus includes a substrate, a first heating element, and a second heating element. The substrate includes a first portion, a second portion, and a third portion that is between the first portion and the second portion. The first portion is characterized by a first thermal conductivity, the second portion is characterized by a second thermal conductivity, and the third portion is characterized by a third thermal conductivity. The third thermal conductivity is less than the first thermal conductivity and the second thermal conductivity. The first heating element is coupled to the first portion of the substrate, and is configured to produce a first thermal output. The second heating element is coupled to the second portion of the substrate, and configured to produce a second thermal output. The second thermal output is different from the first thermal output.
    Type: Application
    Filed: May 25, 2021
    Publication date: September 16, 2021
    Applicant: Visby Medical, Inc.
    Inventors: Boris ANDREYEV, Brian CIOPYK, Victor BRIONES, Jonathan HONG, David SWENSON, Gregory LONEY, Adam DE LA ZERDA, Steven CHU
  • Publication number: 20210237090
    Abstract: An apparatus includes a substrate, a first heating element, and a second heating element. The substrate includes a first portion, a second portion, and a third portion that is between the first portion and the second portion. The first portion is characterized by a first thermal conductivity, the second portion is characterized by a second thermal conductivity, and the third portion is characterized by a third thermal conductivity. The third thermal conductivity is less than the first thermal conductivity and the second thermal conductivity. The first heating element is coupled to the first portion of the substrate, and is configured to produce a first thermal output. The second heating element is coupled to the second portion of the substrate, and configured to produce a second thermal output. The second thermal output is different from the first thermal output.
    Type: Application
    Filed: April 19, 2021
    Publication date: August 5, 2021
    Applicant: Visby Medical, Inc.
    Inventors: Boris ANDREYEV, Brian CIOPYK, Victor BRIONES, Jonathan HONG, David SWENSON, Gregory LONEY, Adam DE LA ZERDA, Steven CHU
  • Patent number: 10987674
    Abstract: An apparatus includes a substrate, a first heating element, and a second heating element. The substrate includes a first portion, a second portion, and a third portion that is between the first portion and the second portion. The first portion is characterized by a first thermal conductivity, the second portion is characterized by a second thermal conductivity, and the third portion is characterized by a third thermal conductivity. The third thermal conductivity is less than the first thermal conductivity and the second thermal conductivity. The first heating element is coupled to the first portion of the substrate, and is configured to produce a first thermal output. The second heating element is coupled to the second portion of the substrate, and configured to produce a second thermal output. The second thermal output is different from the first thermal output.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: April 27, 2021
    Assignee: Visby Medical, Inc.
    Inventors: Boris Andreyev, Brian Ciopyk, Victor Briones, Jonathan Hong, David Swenson, Gregory Loney, Adam De La Zerda, Steven Chu
  • Publication number: 20210071236
    Abstract: A method includes coupling a molecular diagnostic test device to a power source. A biological sample is conveyed into a sample preparation module. The device is then actuated by only a single action to cause the device to perform the following functions without further user action. First, the device heats the sample via a heater of the sample preparation module to lyse a portion of the sample. Second, the device conveys the lysed sample to an amplification module and heats the sample within a reaction volume of the amplification module to amplify a nucleic acid thereby producing an output solution containing a target amplicon. The device then reacts, within a detection module, each of (i) the output solution and (ii) a reagent formulated to produce a signal that indicates a presence of the target amplicon within the output solution. A result associated with the signal is then read.
    Type: Application
    Filed: November 9, 2020
    Publication date: March 11, 2021
    Applicant: Visby Medical, Inc.
    Inventors: Boris ANDREYEV, Victor BRIONES, Ryan T. CENA, Adam DE LA ZERDA, Colin KELLY, Gregory LONEY, Gary SCHOOLNIK, David SWENSON
  • Publication number: 20210039097
    Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.
    Type: Application
    Filed: October 14, 2020
    Publication date: February 11, 2021
    Applicant: Visby Medical, Inc.
    Inventors: Boris ANDREYEV, Keith E. MORAVICK, Brian CIOPYK, Victor BRIONES, Gregory LONEY, Adam DE LA ZERDA, Jesus CHING, Steven CHU, David SWENSON, Helen HUANG, Colin KELLY
  • Publication number: 20200406256
    Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.
    Type: Application
    Filed: September 11, 2020
    Publication date: December 31, 2020
    Applicant: Visby Medical, Inc.
    Inventors: Boris ANDREYEV, Keith E. MORAVICK, Brian CIOPYK, Victor BRIONES, Gregory LONEY, Adam DE LA ZERDA, Jesus CHING, Steven CHU, David SWENSON, Helen HUANG, Colin KELLY
  • Publication number: 20200346213
    Abstract: A method includes conveying a detection solution containing a target amplicon into a detection module of a molecular diagnostic test device. The detection module includes a detection surface including a series of capture probes to which a first portion of the target amplicon is bound when the detection solution is conveyed. A first reagent formulated to produce a visible signal indicating a presence of the target amplicon is then conveyed into the detection module. The first reagent is bound to a second portion of the target amplicon when the first reagent is conveyed. A second reagent is conveyed into the detection module. The second reagent includes a precipitating substrate formulated to catalyze the production of the visible signal by producing an insoluble colored product when the second reagent is in contact with the first reagent. The method includes viewing the visible signal via a transparent portion of the detection module.
    Type: Application
    Filed: June 3, 2020
    Publication date: November 5, 2020
    Applicant: Visby Medical, Inc.
    Inventors: Boris ANDREYEV, Rajinder K. BHATIA, Victor BRIONES, Phoebe CAO, Jesus CHING, Brian CIOPYK, Adam DE LA ZERDA, Jonathan H. HONG, Helen HUANG, Colin KELLY, Adrienne C. LAM, Gregory LONEY, Danielle MCSHEERY, Keith E. MORAVICK, Valeria REVILLA, Shaunak ROY, David D. SWENSON
  • Patent number: 10675623
    Abstract: A method includes conveying a detection solution containing a target amplicon into a detection module of a molecular diagnostic test device. The detection module includes a detection surface including a series of capture probes to which a first portion of the target amplicon is bound when the detection solution is conveyed. A first reagent formulated to produce a visible signal indicating a presence of the target amplicon is then conveyed into the detection module. The first reagent is bound to a second portion of the target amplicon when the first reagent is conveyed. A second reagent is conveyed into the detection module. The second reagent includes a precipitating substrate formulated to catalyze the production of the visible signal by producing an insoluble colored product when the second reagent is in contact with the first reagent. The method includes viewing the visible signal via a transparent portion of the detection module.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: June 9, 2020
    Assignee: Visby Medical, Inc.
    Inventors: Boris Andreyev, Rajinder K. Bhatia, Victor Briones, Phoebe Cao, Jesus Ching, Brian Ciopyk, Adam De La Zerda, Jonathan H. Hong, Helen Huang, Colin Kelly, Adrienne C. Lam, Gregory Loney, Danielle McSheery, Keith E. Moravick, Valeria Revilla, Shaunak Roy, David D. Swenson
  • Patent number: 10525469
    Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: January 7, 2020
    Assignee: Visby Medical, Inc.
    Inventors: Boris Andreyev, Keith E. Moravick, Brian Ciopyk, Victor Briones, Gregory Loney, Adam De La Zerda, Jesus Ching, Steven Chu, David Swenson, Helen Huang, Colin Kelly