Patents by Inventor Gregory M. Barton

Gregory M. Barton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR CAS IMMUNE TOLERANCE INDUCTION TO SUPPORT CRISPR-CAS IN VIVO GENE EDITING
    Publication number: 20250375508
    Abstract: Tolerogenic compositions are disclosed that are of use for inducing a tolerogenic immune response to a CRISPR-Cas effector polypeptide in a subject. In some aspects, the tolerogenic composition includes: a) one or more microparticles; b) one or more regulatory T cell (Treg) stimulating agents encapsulated within each microparticle; and c) a CRISPR-Cas effector polypeptide or immunogenic fragment thereof, or a fusion polypeptide comprising a CRISPR-Cas effector polypeptide or immunogenic fragment thereof. In other aspects, the tolerogenic composition includes a) a dissolvable microneedle array; b) one or more agents that promote differentiation of tolerogenic DCs in the dissolvable microneedle array; and c) a CRISPR-Cas effector polypeptide or immunogenic fragment thereof, or a fusion polypeptide comprising a CRISPR-Cas effector polypeptide or immunogenic fragment thereof.
    Type: Application
    Filed: June 28, 2023
    Publication date: December 11, 2025
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, The Regents of the University of California
    Inventors: Stephen C. Balmert, Louis D. Falo, Steven R. Little, David H. Raulet, Gregory M. Barton, Emrullah Korkmaz
  • Methods and Compositions for Modulating Toll-Like Receptor 7 (TLR7) Function
    Publication number: 20230303642
    Abstract: Disclosed herein are Unc93bl mutations that modulated the trafficking and/or signaling of TLR7, and compositions and methods of using thereof.
    Type: Application
    Filed: June 6, 2021
    Publication date: September 28, 2023
    Inventors: Gregory M. Barton, Nicholas Anton Lind, Olivia Majer, Bo Liu
  • Methods and Compositions for Modulating Toll-Like Receptor 3 (TLR3) Function
    Publication number: 20230295253
    Abstract: Disclosed herein are Unc93b1 mutations that modulated the trafficking and/or signaling of TLR3, and compositions and methods of using thereof.
    Type: Application
    Filed: June 6, 2021
    Publication date: September 21, 2023
    Inventors: Gregory M. Barton, Nicholas Anton Lind, Olivia Majer, Bo Liu
  • Methods and Compositions for Modulating Toll-Like Receptor 5 (TLR5) Function
    Publication number: 20230287078
    Abstract: Disclosed herein are Unc93b1 mutations that modulated the trafficking and/or signaling of TLR5, and compositions and methods of using thereof.
    Type: Application
    Filed: June 6, 2021
    Publication date: September 14, 2023
    Inventors: Gregory M. Barton, Nicholas Anton Lind, Olivia Majer, Bo Liu
  • Methods and Compositions for Modulating Toll-Like Receptor 9 (TLR9) Function
    Publication number: 20230250144
    Abstract: Disclosed herein are Unc93b1 mutations that modulated the trafficking and/or signaling of TLR9, and compositions and methods of using thereof.
    Type: Application
    Filed: June 6, 2021
    Publication date: August 10, 2023
    Inventors: Gregory M. Barton, Nicholas Anton Lind, Olivia Majer, Bo Liu
  • Water craft
    Patent number: D364599
    Type: Grant
    Filed: January 6, 1995
    Date of Patent: November 28, 1995
    Assignee: Ocean Kayak, Inc.
    Inventor: Gregory M. Barton