Patents by Inventor Gregory M. Duke

Gregory M. Duke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Attenuation of cytomegalovirus virulence
    Patent number: 7611718
    Abstract: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: November 3, 2009
    Assignee: MedImmune, LLC
    Inventors: George Kemble, Gregory M. Duke, Richard Spaete
  • Attenuation of cytomegalovirus virulence
    Patent number: 7550149
    Abstract: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: June 23, 2009
    Assignee: MedImmune, LLC
    Inventors: George Kemble, Gregory M. Duke, Richard Spaete
  • Attenuation of cytomegalovirus virulence
    Patent number: 7537770
    Abstract: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: May 26, 2009
    Assignee: MedImmune, LLC
    Inventors: George Kemble, Gregory M. Duke, Richard Spaete
  • Attenuation of Cytomegalovirus Virulence
    Publication number: 20080019945
    Abstract: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
    Type: Application
    Filed: December 20, 2006
    Publication date: January 24, 2008
    Applicant: Medlmmune Vaccines, Inc.
    Inventors: George Kemble, Gregory M. Duke, Richard Spaete
  • Attenuation of cytomegalovirus virulence
    Patent number: 7204990
    Abstract: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: April 17, 2007
    Assignee: MedImmune Vaccines, Inc.
    Inventors: George Kemble, Gregory M. Duke, Richard Spaete
  • Method of inhibiting picornavirus disease
    Patent number: 5229111
    Abstract: A method for inhibiting picornavirus disease in non-murine mammals is disclosed. A vaccine containing a live, recombinant, attenuated picornavirus with a shortened poly(C) tract is administered to the mammal. Preferably, the picornavirus in the vaccine is of the same genus as the disease-causing picornavirus and has a shortened poly(C) tract. The administration of the vaccine causes antibodies effective against the disease-causing picornavirus to be formed in vivo. In one embodiment of the invention, a vaccine containing Mengovirus with a shortened poly(C) tract can be used as a vaccine for both pigs and monkeys.
    Type: Grant
    Filed: January 31, 1991
    Date of Patent: July 20, 1993
    Assignee: Wiscosnin Alumni Research Foundation
    Inventors: Ann C. Palmenberg, Gregory M. Duke, Jorge E. Osorio
  • Translation enhancer
    Patent number: 4937190
    Abstract: Disclosed in this patent are DNA sequences, RNA sequences, vectors, and hosts that incorporate a translation enhancer region derived from the 5' non-coding region of a cardiovirus. The enhancer acts at the RNA level (as opposed to the DNA level) to enhance production of proteins in cell free media. Proteinaceous material which is produced will not have attached to it any undesired material from the enhancer sequence. The invention is especially useful to enable efficient production of selected viral proteins of picornoviruses.
    Type: Grant
    Filed: October 15, 1987
    Date of Patent: June 26, 1990
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ann C. Palmenberg, Gregory M. Duke, Parks, Griffith D.