Patents by Inventor Gregory Malaise

Gregory Malaise has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7622591
    Abstract: The present invention is concerned with a novel process for the manufacture of 4alkanoyloxy-2,3,5-trimethylphenyl (E/Z)-phytyl ethers, precursors of ?-tocopheryl alkanoates, by cross-metathesis reaction of alkenyl ethers of 1-alkanoyloxy-2,3,6-trimethylhydroquinone with 2,6,10,14-tetramethylpentadecene or a phytol derivative, e.g. an ester, an ether or a silyl ether, in the presence of a cross-metathesis catalyst. As the crossmetathesis catalyst especially ruthenium metal carbene complexes are suitable which possess (a) ruthenium metal center(s), have an electron count of 16 or 18 and are penta- or hexa-coordinated. A further object of the invention is a process for the manufacture of ?tocopheryl alkanoates comprising this reaction.
    Type: Grant
    Filed: September 2, 2004
    Date of Patent: November 24, 2009
    Assignee: DSM IP Assets B.V.
    Inventors: Werner Bonrath, Manfred Breuninger, Grégory Malaisé, Thomas Netscher
  • Publication number: 20060235234
    Abstract: The present invention is concerned with a novel process for the manufacture of (E/Z)-4-alkanoyloxy-3,5,6-trimethyl-2-phytylphenyl esters and silyl ethers, precursors of ?-tocopherol and ?-tocopheryl alkanoates, by cross-metathesis reaction of 2-alkenyl-3,5,6-trimethylhydroquinone dialkanoates or 4-alkanoyloxy-2-alkenyl-3,5,6-trimethylphenyl silylethers with 2,6,10,14-tetramethylpentadecene or a phytol derivative, e.g. phytyl acetate, in the presence of a cross-metathesis catalyst. As the cross-metathesis catalyst especially ruthenium metal carbene complexes are suitable which possess (a) ruthenium metal center(s), have an electron count of 16 or 18 and are penta- or hexa-coordinated. A further object of the invention is a process for the manufacture of ?-tocopherol and ?-tocopheryl alkanoates comprising this reaction.
    Type: Application
    Filed: September 2, 2004
    Publication date: October 19, 2006
    Inventors: Werner Bonrath, Manfred Breuninger, Gregory Malaise, Thomas Netscher