Abstract: Embodiments disclosed herein are directed to a self-learning bladder volume monitoring system. The system can include a bladder volume (BV) system configured to measure an electrical impedance of a bladder region of a patient and determine a volume of fluid disposed therein using an impedance to bladder volume model (“By model”). Further, the system can measure a total body water (“TBW”) for the patient and modify the BV model to account for variations in TBW within the tissues surrounding the bladder providing a more accurate bladder volume measurement. The system can include a “training unit” which can include one of a user input interface, an automatic urine output monitoring system, an ultrasound system, and an intrabladder pressure system configured to verify a volume of fluid within or voided from the bladder and train the BV model.

Abstract: Examples relate to devices, systems, and methods for fluid collection such as urine. A urine collection system includes a urine collection device configured to be positioned at least proximate to a urethra of a user, a canister having an interior region, a first conduit in fluid communication with the urine collection device and the canister, and one or more of a urine volume indicator, a flow indicator, and/or a pressure indicator.

Abstract: The present disclosure relates to biocatalytic ligation methods for producing oligonucleotides; and to fusion polypeptides for use in said methods. In particular, the present disclosure relates to biocatalytic ligation methods incorporating ATP regeneration and to fusion polypeptides comprising a polyphosphate kinase domain and an ATP-dependent nucleic acid ligase domain.

Abstract: The present disclosure relates to a process for producing chiral ?-nitro alcohol compounds. The invention relates in particular to an (S)-selective oxynitrilase, which enantioselectively can catalyze the Henry reaction, wherein an aldehyde or ketone compound is converted to the corresponding ?-nitro alcohol compound in the presence of a nitroalkane compound and an oxynitrilase.

Abstract: An example fluid collection assembly includes a fluid impermeable barrier defining at least a chamber, at least one opening, and a fluid outlet. The fluid collection assembly also includes at least one porous material disposed in the chamber and an adjustable spine. The adjustable spine is configured to selectively change the shape of at least a portion of the fluid collection assembly. For example, the adjustable spine includes a first strip and a second strip. The second strip is configured to switch from at least a relaxed configuration to a stressed configuration. The fluid collection assembly may exhibit a first shape when the second strip is in the relaxed configuration and a second shape that is different than the first shape when the second strip is in the stressed configuration.

Abstract: A urinary output monitoring system including a urine collection assembly coupled with an automated urinary output monitoring device. The urine collection assembly includes a drainage tube, an accumulator coupled with the drainage tube, and a urine collection container fluidly coupled with the accumulator. The automated urinary output monitoring device operatively is coupled with the urine collection container. Logic determines a volume of urine collected in the container based on a signal from a load cell of the monitoring device. A vacuum pump coupled with the accumulator generates a flow of air that the drags the urine along the drainage tube to the accumulator. The accumulator separates the flow of air from the urine. The flow of air enters the drainage tube by way of a female external urinary catheter.

Abstract: An example fluid collection device includes a fluid impermeable barrier and a base. The fluid impermeable base at least partially defines a chamber within the fluid collection device. The base is secured to the fluid impermeable barrier and at least partially defines the chamber and an opening in fluid communication with the chamber. The base includes at least a first layer including at least a nonwoven fabric extending at least partially between a proximal end region and a distal end region of the fluid collection device. The base also may include a second layer secured to the first layer and at least partially defining the chamber. The second layer includes a fluid permeable multilayer fabric at least partially positioned between the first layer and the chamber and extending at least partially between the proximal end region and the distal end region.

Abstract: An example fluid collection assembly (100) includes a sheath (102) and a base (104). The sheath includes a fluid impermeable barrier (106) formed from at least a first panel (108) and a second panel (110). The first panel and the second panel at least partially define a chamber (112) therebetween. The fluid impermeable barrier also defines a fluid outlet (118) at a distal end of the sheath and an opening (114) at a proximal end of the sheath. The sheath also includes at least one porous material (122) disposed in the chamber. The base is permanently secured or configured to be permanently secured to the sheath. The base defines an aperture (124) that is aligned with the opening when the base is permanently attached to the sheath. The base is configured to be secured to a region about a penis of an individual with the aperture positioned over the penis.

Abstract: Embodiments are directed to support structures for drainage tubes to relax dependent loops and mitigate fluid pooling. Embodiments include support structures configured to receive an elastic tube and impart rigid or malleable properties thereon. These properties allow a clinician to position the tube to provide a consistent negative incline. Embodiments of support structures include an interlocking segmented tube, a bi-stable or mono-stable support structure, a jacket support structure, or a magnet support structure. Embodiments further include a malleable wire disposed within a wall of an elastic tube, or portions of a tube displaying differing elastic, malleable, or rigid properties. Embodiments also include magnetic peristalsis devices configured to urge fluid through a tube lumen.

Abstract: Embodiments disclosed herein are directed to a self-learning bladder volume monitoring system. The system can include a bladder volume (BV) system configured to measure an electrical impedance of a bladder region of a patient and determine a volume of fluid disposed therein using an impedance to bladder volume model (“By model”). Further, the system can measure a total body water (“TBW”) for the patient and modify the BV model to account for variations in TBW within the tissues surrounding the bladder providing a more accurate bladder volume measurement. The system can include a “training unit” which can include one of a user input interface, an automatic urine output monitoring system, an ultrasound system, and an intrabladder pressure system configured to verify a volume of fluid within or voided from the bladder and train the BV model.

Abstract: An example fluid collection assembly (100) includes a sheath (102) and a base (104). The sheath includes a fluid impermeable barrier (106) formed from at least a first panel (108) and a second panel (110). The first panel and the second panel at least partially define a chamber (112) therebetween. The fluid impermeable barrier also defines a fluid outlet (118) at a distal end of the sheath and an opening (114) at a proximal end of the sheath. The sheath also includes at least one porous material (122) disposed in the chamber. The base is permanently secured or configured to be permanently secured to the sheath. The base defines an aperture (124) that is aligned with the opening when the base is permanently attached to the sheath. The base is configured to be secured to a region about a penis of an individual with the aperture positioned over the penis.

Abstract: Examples relate to devices, systems, and methods for fluid collection such as urine. A urine collection system includes a urine collection device configured to be positioned at least proximate to a urethra of a user, a canister having an interior region, a first conduit in fluid communication with the urine collection device and the canister, and one or more of a urine volume indicator, a flow indicator, and/or a pressure indicator.

Abstract: Disclosed herein is a urine output measuring system including a urine hat having a urine hat body including a rim, the urine hat defining a cavity configured to receive a volume of urine, a plurality of feet defining a platform configured to be coupled to a toilet to suspend the urine hat, and one or more sensors coupled to the platform, the one or more sensors being in communication with a console and configured to detect and transmit one or more load values to the console.

Abstract: An example fluid collection assembly includes a fluid impermeable barrier defining at least a chamber, at least one opening, and a fluid outlet. The fluid collection assembly also includes at least one porous material disposed in the chamber and an adjustable spine. The adjustable spine is configured to selectively change the shape of at least a portion of the fluid collection assembly. For example, the adjustable spine includes a first strip and a second strip. The second strip is configured to switch from at least a relaxed configuration to a stressed configuration. The fluid collection assembly may exhibit a first shape when the second strip is in the relaxed configuration and a second shape that is different than the first shape when the second strip is in the stressed configuration.

Abstract: Embodiments disclosed herein are directed to support structures for drainage tubes to relax dependent loops and mitigate fluid pooling. Embodiments include support structures configured to receive an elastic tube and impart rigid or malleable properties thereon. These properties allow a clinician to position the tube to provide a consistent negative incline. Embodiments of support structures include an interlocking segmented tube, a bi-stable or mono-stable support structure, a jacket support structure, or a magnet support structure. Embodiments further include a malleable wire disposed within a wall of an elastic tube, or portions of a tube displaying differing elastic, malleable, or rigid properties. Also disclosed are magnetic peristalsis devices configured to urge fluid through a tube lumen.

Abstract: An improved medical procedure or catheterization tray included in an improved medical procedure or catheterization package. The improved medical procedure or catheterization tray is intuitively arranged and includes instructions printed thereon to improve the medical procedure or catheterization implementation and results. In one example, a catheterization package and catheterization tray has a layout and/or arrangement of components that may help reduce CAUTI rates by facilitating ease of use and aiding in proper aseptic technique during insertion. The medical procedure or catheterization package and/or medical procedure or catheterization tray may include various implements, compartments, and components necessary and/or helpful to the medical procedure or catheterization, including, for example, improved swabs and an improved compartment for holding the swabs.

Abstract: Embodiments of the invention include materials, devices, systems, and methods for identifying female urethra and facilitating catheterization. For instance, materials, devices, systems, and methods described herein may facilitate marking of female urethra, which may lead to increase in insertion accuracy and may reduce time for completing the catheterization procedure.

Abstract: An improved medical procedure or catheterization tray included in an improved medical procedure or catheterization package. The improved medical procedure or catheterization tray is intuitively arranged and includes instructions printed thereon to improve the medical procedure or catheterization implementation and results. In one example, a catheterization package and catheterization tray has a layout and/or arrangement of components that may help reduce CAUTI rates by facilitating ease of use and aiding in proper aseptic technique during insertion. The medical procedure or catheterization package and/or medical procedure or catheterization tray may include various implements, compartments, and components necessary and/or helpful to the medical procedure or catheterization, including, for example, improved swabs and an improved compartment for holding the swabs.

Abstract: Disclosed are embodiments of a manufacturing method that establishes a library of pre-made and pre-qualified masks for patterning different blocks of circuitry that meet established performance and timing requirements. The embodiments of the method use stepped exposures of multiple masks, including at least one mask selected from this library, to pattern a chip design onto a silicon wafer, where the chip design is made up of two or more interconnected blocks of circuitry. Consequently, for a given integrated circuit design, pre-made/pre-qualified mask(s) can be selected from the library to pattern one, some or all blocks of circuitry for the design. Optionally, additional masks can be specially made and qualified to pattern other block(s) of circuitry (e.g., application specific logic) within the design. The blocks of circuitry patterned in this manner can be electrically connected via generic or customized interfaces in order to complete the chip design.

Abstract: An antimicrobial and hydrophilic article that is microbial resistant comprises an antimicrobial agent and a hydrophilic agent combined with a base material. The combination can be extruded, calandarized, or molded to form the medical article, ensuring that the anti-microbial properties are not localized at the surface. The entire bulk of the article, including the surface thereof, is capable of having anti-microbial characteristics, allowing refreshening of the surface with time.