Abstract: There is disclosed an assay method for selectively detecting 1,25-dihydroxy-vitamin D in a biological fluid sample. According to the method, the pH of the test sample is adjusted to 6-9 and a receptor protein comprising the Ligand Binding Domain of Vitamin D Receptor (VDR-LBD) is added to the test sample, thereby obtaining the formation of a VDR-LBD/1,25-dihydroxyvitamin D complex in which the VDR-LBD portion is conformationally changed with respect to unbound VDR-LBD. The VDR-LBD/1,25-dihydroxyvitamin D complex is then detected by means of a capture moiety which is capable of specifically binding to VDR-LBD bound to 1,25-dihydroxyvitamin D. Also disclosed are an assay kit and an antibody for carrying out the method. The assay is preferably a sandwich immunoassay.

Abstract: A dumbbell system a plurality of weights vertically stackable on top of each other and each of the weights has a pair of outer edges disposed oppositely from each other to define a first lateral edge and a second lateral edge. The weights each have a centrally displaced opening vertically extending therethrough and defining a receiving space. The receiving space of each weight is vertically aligned with the receiving space of each of the other weights. A handle is removably extendable into the receiving space. A coupler releasably engages a selected one of the weights to the handle and defines a coupled weight. The coupled weight and each of the weights positioned above the coupled weight is releasably secured to the handle. Each of the weights positioned below the coupled weight are disengaged from the handle.

Abstract: The present invention relates to the use of 1,25-dihydroxyvitamin D values in ratio with PTH as a prognostic biomarker. More particularly, the present invention relates to a method for predicting or stratifying the risk of worsening renal function (WRF) in a patient at risk of renal injury or affected by renal injury. Levels of 1,25-dihydroxyvitamin D (1,25(OH)2D) are measured in a biological sample and taken together with parathyroid hormone (PTH) levels to provide a ratio indicative of the risk of worsening renal function.

Abstract: A high density mapping and ablation catheter includes a tip electrode positioned at its distal end and a plurality of electrodes (e.g., ring electrodes, ring-segment electrodes, spot electrodes, and/or printed traces) disposed proximally of the tip electrode within the distal region. A plurality of conductors extending through the elongate catheter body to electrically connect the tip electrode and other electrodes to a source of ablation energy, an electrophysiology mapping device, and/or a programmable electric stimulator. A switching circuit can be employed, for example to enable a practitioner to selectively activate certain electrodes for ablation, for electrophysiological mapping, for pacing, or to deactivate certain electrodes entirely.

Abstract: There is disclosed an assay method for selectively detecting 1,25-dihydroxy-vitamin D in a biological fluid sample. According to the method, the pH of the test sample is adjusted to 6-9 and a receptor protein comprising the Ligand Binding Domain of Vitamin D Receptor (VDR-LBD) is added to the test sample, thereby obtaining the formation of a VDR-LBD/1,25-dihydroxyvitamin D complex in which the VDR-LBD portion is conformationally changed with respect to unbound VDR-LBD. The VDR-LBD/1,25-dihydroxyvitamin D complex is then detected by means of a capture moiety which is capable of specifically binding to VDR-LBD bound to 1,25-dihydroxyvitamin D. Also disclosed are an assay kit and an antibody for carrying out the method. The assay is preferably a sandwich immunoassay.

Abstract: There is disclosed an assay method for selectively detecting 1,25-dihydroxy-vitamin D in a biological fluid sample. According to the method, the pH of the test sample is adjusted to 6-9 and a receptor protein comprising the Ligand Binding Domain of Vitamin D Receptor (VDR-LBD) is added to the test sample, thereby obtaining the formation of a VDR-LBD/1,25-dihydroxyvitamin D complex in which the VDR-LBD portion is conformationally changed with respect to unbound VDR-LBD. The VDR-LBD/1,25-dihydroxyvitamin D complex is then detected by means of a capture moiety which is capable of specifically binding to VDR-LBD bound to 1,25-dihydroxyvitamin D. Also disclosed are an assay kit and an antibody for carrying out the method. The assay is preferably a sandwich immunoassay.

Abstract: There is disclosed an assay method for selectively detecting 1,25-dihydroxy-vitamin D in a biological fluid sample. According to the method of the invention, the pH of the test sample is adjusted to 6-9 and a receptor protein comprising the Ligand Binding Domain of Vitamin D Receptor (VDR-LBD) is added to the test sample, thereby obtaining the formation of a VDR-LBD/1,25-dihydroxyvitamin D complex in which the VDR-LBD portion is conformationally changed with respect to unbound VDR-LBD. The VDR-LBD/1,25-dihydroxyvitamin D complex is then detected by means of a capture moiety which is capable of specifically binding to VDR-LBD bound to 1,25-dihydroxyvitamin D. Also disclosed are an assay kit and an antibody for carrying out the method of the invention. The assay of the invention is preferably a sandwich immunoassay.

Abstract: A high density mapping and ablation catheter includes a tip electrode positioned at its distal end and a plurality of electrodes (e.g., ring electrodes, ring-segment electrodes, spot electrodes, and/or printed traces) disposed proximally of the tip electrode within the distal region. A plurality of conductors extending through the elongate catheter body to electrically connect the tip electrode and other electrodes to a source of ablation energy, an electrophysiology mapping device, and/or a programmable electric stimulator. A switching circuit can be employed, for example to enable a practitioner to selectively activate certain electrodes for ablation, for electrophysiological mapping, for pacing, or to deactivate certain electrodes entirely.

Abstract: There is disclosed an assay method for selectively detecting 1,25-dihydroxy-vitamin D in a biological fluid sample. According to the method, the pH of the test sample is adjusted to 6-9 and a receptor protein comprising the Ligand Binding Domain of Vitamin D Receptor (VDR-LBD) is added to the test sample, thereby obtaining the formation of a VDR-LBD/1,25-dihydroxyvitamin D complex in which the VDR-LBD portion is conformationally changed with respect to unbound VDR-LBD. The VDR-LBD/1,25-dihydroxyvitamin D complex is then detected by means of a capture moiety which is capable of specifically binding to VDR-LBD bound to 1,25-dihydroxyvitamin D. Also disclosed are an assay kit and an antibody for carrying out the method. The assay is preferably a sandwich immunoassay.

Abstract: There is disclosed an assay method for selectively detecting 1,25-dihydroxy-vitamin D in a biological fluid sample. According to the method of the invention, the pH of the test sample is adjusted to 6-9 and a receptor protein comprising the Ligand Binding Domain of Vitamin D Receptor (VDR-LBD) is added to the test sample, thereby obtaining the formation of a VDR-LBD/1,25-dihydroxyvitamin D complex in which the VDR-LBD portion is conformationally changed with respect to unbound VDR-LBD. The VDR-LBD/1,25-dihydroxyvitamin D complex is then detected by means of a capture moiety which is capable of specifically binding to VDR-LBD bound to 1,25-dihydroxyvitamin D. Also disclosed are an assay kit and an antibody for carrying out the method of the invention. The assay of the invention is preferably a sandwich immunoassay.

Abstract: In various embodiments, an adaptive spectral surface is provided including an upper layer having a frequency selective surface, a lower layer being at least partially reflective, and an active dielectric material layer therebetween. The active dielectric material may include a dielectric material with an adjustable permittivity, permeability, or thickness. The active dielectric material may be a dielectric material adapted to change its dielectric constant in response to at an applied electric field, an applied magnetic field, or/and thermal stimulus. Some embodiments allow shifting of the resonance of the spectral absorptive/reflective emissions of the adaptive spectral surface. Some embodiments allow modification of the electromagnetic signature of an adaptive spectral surface apparatus.

Abstract: A medical device shaft with varying flexibility along its length is provided. The shaft includes at least first and second elongate shaft portions that have differing geometries and differing flexibilities. The elongate shaft portions can be made of different materials.

Abstract: A method and system for financial allocation and forecasting for calculating daily, weekly, and monthly spending rates that can be used by a company or a person is disclosed, providing an over/under forecast variance. The forecast variance is converted to the number of days required to reduce all spending to zero to eliminate over spending. The method receives financial data either manually or by a program application and treats all transactions as cash equivalents. The method includes a plurality of program applications formulated to generate a plurality of forecasting parameters. A rate factor which is a subjective decision of the user is received from a range ?3 to +3 to automatically calculate an under/over value variance. The invention utilizes Gregorian calendar that has a five week month occurring every three months to identify 7.7% savings of yearly income. Further, the method converts the irregular yearly and quarterly expenses into monthly amounts and put the expenses in savings.

Abstract: Alternative designs, materials, and methods of making and using catheter manifolds. Some embodiments are related to a balloon catheter including a catheter shaft having a proximal portion and a distal portion. The shaft includes an outer tubular member defining a lumen and having a proximal end and a distal end. The shaft also includes an inner tubular member defining a lumen and having a proximal end and a distal end. The inner tubular member is disposed at least partially within the outer tubular member such that the proximal end of the inner tubular member extends proximally from the proximal end of the outer tubular member. A catheter manifold is molded about a portion of the outer tubular member and a portion of the inner tubular member, and a balloon assembly attached to the distal portion of the shaft such that the balloon assembly is in fluid communication with at least one of the lumens.

Abstract: Medical devices, including intravascular medical devices, may be constructed to include on-board power generation capabilities adapted to provide power to an electrical load, such as a therapeutic element, that is disposed upon or formed within the medical device. An electrical power generator may be disposed upon or formed within a proximal portion of a medical device.

Abstract: A selectorized dumbbell has a handle that can be inserted into a gap between stacks of nested left and right weight plates. A selector determines how many left weight plates are coupled to the left end of the handle and how many right weight plates are coupled to the right end of the handle. Each weight plate is held between a pair of flexible arms on a forked carrier. The arms allow the weight plates to deflect out of a normal, substantially upright, orientation if an impact shock is delivered to the dumbbell. The arms are restored to their normal orientation once the impact shock dissipates. Alternatively, the weight plates may comprise a metallic inner weight plate covered with an elastomer encasement and with an integral elastomer lug attaching the weight plates to at least one interconnecting member. The selector may comprise a connecting pin with at least one flexible shock absorbing prong.

Abstract: High-strength, low-hysteresis TiNi-based shape-memory alloys (SMAs) employing fully coherent low-misfit nanoscale precipitates, wherein the precipitate phase is based on an optimized composition for high parent-phase strength and martensite phase stability, and compensating the stored elastic energy through the addition of martensite stabilizers. The alloys, with a yield strength in excess of 1200 MPa, are useful for applications such as self-expanding stents, automotive actuators, and other applications wherein SMAs with high output force and long cyclic life are desired.

Abstract: A structure can be installed in and removed from a body of water in a seasonal fashion. The structure has a lower level that includes a boat lift and may include an upper level that provides an entertainment area. The structure carries a buoyancy system for selectively floating the structure on the body of water or sinking the structure in the water. A substantially enclosed boathouse may form the structure when the structure has only a lower level. The boathouse is separable into sections each of which could be separately rolled over the ground by wheels attached to each section. This reduces the usual operational width of the boathouse into the smaller towed widths of the individual sections to ease the task of transporting the boathouse over the ground.

Abstract: A transformation toughened, high-strength steel alloy useful in plate steel applications achieves extreme fracture toughness (Cv & gt; 80 ft-lbs corresponding to KId & equals; 200 ksi.in½) at strength levels of 150-180 ksi yield strength, is weldable and formable. The alloy is characterized by dispersed austenite stabilization for transformation toughening to a weldable, bainitic plate steel and is strengthened by precipitation of M2C carbides in combination with copper and nickel. The desired microstructure is a matrix containing a bainite-martensite mix, BCC copper and M2C carbide particles for strengthening with a fine dispersion of optimum stability austenite for transformation toughening. The bainite-martensite mix is formed by air-cooling from solution treatment temperature and subsequent aging at secondary hardening temperatures to precipitate the toughening and strengthening dispersions.

Abstract: A medical device shaft with varying flexibility along its length is provided. The shaft includes at least first and second elongate shaft portions that have differing geometries and differing flexibilities. The elongate shaft portions can be made of different materials.