Patents by Inventor Gregory Pacofsky
Gregory Pacofsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10155725Abstract: The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.Type: GrantFiled: December 28, 2015Date of Patent: December 18, 2018Assignee: MERIAL, INC.Inventors: Charles Q. Meng, Alan Long, Scot Huber, Srinivas Reddy Gurrala, Douglas Edward Wilkinson, Gregory Pacofsky
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Publication number: 20160185726Abstract: The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.Type: ApplicationFiled: December 28, 2015Publication date: June 30, 2016Applicant: MERIAL, INC.Inventors: Charles Q. Meng, Alan Long, Scot Huber, Srinivas Reddy Gurrala, Douglas Edward Wilkinson, Gregory Pacofsky
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Publication number: 20140142114Abstract: The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.Type: ApplicationFiled: November 19, 2013Publication date: May 22, 2014Applicant: Merial LimitedInventors: Charles Q. Meng, Alan Long, Scot Huber, Srinivas Reddy Gurrala, Douglas Edward Wilkinson, Gregory Pacofsky
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Publication number: 20070197523Abstract: The present invention provides novel calcium channel antagonists, and methods of treating disease sates using the novel antagonists.Type: ApplicationFiled: December 20, 2006Publication date: August 23, 2007Applicant: ICAGEN, INC.Inventors: Gregory Pacofsky, Mark Suto, Paul Fritch
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Publication number: 20070173504Abstract: The present invention provides novel calcium channel antagonists, and methods of treating disease sates using the novel antagonists.Type: ApplicationFiled: December 20, 2006Publication date: July 26, 2007Applicant: ICAGEN, INC.Inventors: Gregory Pacofsky, Mark Suto, Paul Fritch
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Publication number: 20070142437Abstract: Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.Type: ApplicationFiled: February 2, 2007Publication date: June 21, 2007Inventors: Matthew Brown, Mui Cheung, Scott Dickerson, Cassandra Gauthier, Philip Harris, Robert Hunter, Gregory Pacofsky, Michael Peel, Jeffrey Stafford
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Publication number: 20070135420Abstract: It has now been found that compounds of the present invention as described in Benzodiazepine derivatives of Formula (I) containing a carboxylic ester moiety and thereby capable of being inactivated by nonspecific tissue esterases in an organ-independent elimination mechanism and thereby providing a more predictable and reproducible pharmacodynamic profile. The compounds of the present invention are suitable for therapeutic purposes, including sedative-hypnotic, anxiolytic, muscle relaxant and anticonvulsant purposes and are useful to be administered intravenously in the following clinical settings: preoperative sedation, anxiolysis, and amnestic use for perioperative events; conscious sedation during short diagnostic, operative or endoscopic procedures; as a component for the induction and maintenance of general anesthesia, prior and/or concomitant to the administration of other anesthetic agents; ICU sedation.Type: ApplicationFiled: January 5, 2007Publication date: June 14, 2007Applicant: CeNes LimitedInventors: Paul Feldman, David Jung, Istvan Kaldor, Gregory Pacofsky, Jeffrey Stafford, Jeffrey Tidwell
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Publication number: 20070135421Abstract: The present invention provides a compound of formula (I): wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy.Type: ApplicationFiled: January 5, 2007Publication date: June 14, 2007Applicant: CeNes LimitedInventors: Paul Feldman, David Jung, Istvan Kaldor, Gregory Pacofsky, Jeffrey Stafford, Jeffrey Tidwell
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Publication number: 20070135419Abstract: The present invention provides a compound of formula (I): wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy.Type: ApplicationFiled: January 5, 2007Publication date: June 14, 2007Applicant: CeNes LimitedInventors: Paul Feldman, David Jung, Istvan Kaldor, Gregory Pacofsky, Jeffrey Stafford, Jeffrey Tidwell
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Publication number: 20070093475Abstract: The present invention provides a compound of formula (I): wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy.Type: ApplicationFiled: December 5, 2006Publication date: April 26, 2007Applicant: CeNes LimitedInventors: Paul Feldman, David Jung, Istvan Kaldor, Gregory Pacofsky, Jeffrey Stafford, Jeffrey Tidwell
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Patent number: 7189712Abstract: Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.Type: GrantFiled: October 10, 2003Date of Patent: March 13, 2007Assignee: SmithKline Beecham CorporationInventors: Matthew Lee Brown, Mui Cheung, Scott Howard Dickerson, Cassandra Gauthier, Philip Anthony Harris, Robert Neil Hunter, Gregory Pacofsky, Michael Robert Peel, Jeffrey Alan Stafford
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Publication number: 20050288515Abstract: Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.Type: ApplicationFiled: October 10, 2003Publication date: December 29, 2005Inventors: Matthew Brown, Mui Cheung, Scott, Howard Dickerson, Cassandra Gauthier, Philip, Anthony Harris, Robert, Neil Hunter, Gregory Pacofsky, Michael, Robert Peel, Jeffrey, Alan Stafford
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Patent number: 5585382Abstract: Anticancer compounds of formula I: ##STR1## and pharmaceutically acceptable salts thereof, wherein: R.sup.1, R.sup.2, R.sup.3, R.sup.9 and R.sup.10 are independently selected from the group H, C.sub.1 -C.sub.4 alkyl, OR.sup.4, N(R.sup.4).sub.2, NO.sub.2, CN, F, Cl, Br, I, Ph, and CF.sub.3, and NHC(O)R.sup.4 ;R.sup.4 is independently selected from the group H, C.sub.1 -C.sub.4 alkyl, Ph, and CH.sub.2 Ph;X.sup.1 and Y.sup.1, and X.sup.2 and Y.sup.2 when present, join together to form:a benzene ring substituted with 1-4 R.sup.3 ;a five membered heterocycle having 1-2N, NH, O or S atoms and substituted with 1-2 R.sup.3 ;a six membered heterocycle having 1-2N and substituted with 1-2 R.sup.3 ; orthe group: ##STR2## wherein one of W or Z is C.dbd.O and the other is C.dbd.O, NH, S or O; or when X.sup.2 and Y.sup.2 are present and not joined together and when R.sup.2 is in the 4-position, then X.sup.2 and R.sup.2 may join together to form an ethylene bridge;are addressed.Type: GrantFiled: February 21, 1995Date of Patent: December 17, 1996Assignee: The DuPont Merck Pharmaceutical CompanyInventors: Arthur D. Patten, Gregory Pacofsky, Steven P. Seitz, Emeka A. Akamike, Robert J. Cherney, Robert F. Kaltenbach, III, Michael J. Orwat
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Patent number: 5416089Abstract: Anticancer compounds of formula I: ##STR1## and pharmaceutically acceptable salts thereof, wherein: R.sup.1, R.sup.2 and R.sup.3 are independently selected H, CH.sub.3, NH.sub.2, NO.sub.2, and CN;R.sup.9 and R.sup.10 are H or alkyl or halo, X.sup.1 and Y.sup.1 or X.sup.2 and Y.sup.2, when present, join together to form, independently, a six membered 1N heterocycle substituted with 1-2 R.sup.3 ; or the group: ##STR2## wherein one of W or Z is C.dbd.O and the other is C.dbd.O, NH, S or O; or when X.sup.2 and Y.sup.2 are not joined together and when R.sup.2 is in the 4-position, then X.sup.2 and R.sup.2 may join together to form an ethylene bridge; are disclosed.Type: GrantFiled: June 24, 1993Date of Patent: May 16, 1995Assignee: The Du Pont Merck Pharmaceutical CompanyInventors: Arthur D. Patten, Gregory Pacofsky, Steven P. Seitz, Emeka A. Akamike, Robert J. Cherney, Robert F. Kaltenbach, III, Michael J. Orwat