Patents by Inventor Gregory Paul Roth

Gregory Paul Roth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODULATORS OF NOD1 AND NOD2 SIGNALING, METHODS OF IDENTIFYING MODULATORS OF NOD1 AND NOD2 SIGNALING, AND USES THEREOF
    Publication number: 20120046329
    Abstract: Disclosed herein are compositions and methods relating to modulators of Nod-like Receptors NOD1 (NLRC1) and NOD2 (NLRC2) signaling. Further provided are methods of identifying modulators of Nod-like Receptors NOD1 and NOD2 activity. Further provided are compositions and methods for treating or preventing inflammation, including diseases associated with inflammation such as inflammatory bowel diseases (Crohn's disease, ulcerative colitis), pancreatitis, arthritis, asthma, psoriasis. Alzheimer's disease, cardiovascular disease (arteritis), diabetes, and sepsis.
    Type: Application
    Filed: August 10, 2011
    Publication date: February 23, 2012
    Inventors: Gregory Paul Roth, Ricardo Garcia Correa, Pasha Moeenuddin Khan, John Christian Reed
  • Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases
    Patent number: 7550461
    Abstract: Disclosed are amide compounds of formula (I): wherein Ar1, Q, Y and R3-R6 of formula (I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: April 10, 2003
    Date of Patent: June 23, 2009
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Donghong Amy Gao, Daniel R. Goldberg, Abdelhakim Hammach, Ming-Hong Hao, Victor Marc Kamhi, Neil Moss, Kevin Chungeng Qian, Gregory Paul Roth, Christopher Ronald Sarko, Alan David Swinamer, Zhaoming Xiong
  • Substituted benzimidazole compounds
    Patent number: 7138420
    Abstract: Disclosed are substituted benzimidazole compounds of formula (I): wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: August 1, 2003
    Date of Patent: November 21, 2006
    Assignee: Boehringer Ingelheim Pharmaceuticals Inc.
    Inventors: Joerg Martin Bentzien, Brian Nicholas Cook, Charles Cywin, Roman Wolfgang Fleck, Ho Yin Lo, Peter Allen Nemoto, Steven S. Pullen, Gregory Paul Roth, Roger John Snow, Hidenori Takahashi, Ji Wang, Kevin J. Moriarty, Lei Qiao, Michael Winters
  • Heterocyclic compounds
    Patent number: 7115644
    Abstract: Disclosed are benzimidazolone compounds of formulas (I) & (II): wherein R1, R2, R3, R4, R5, X, L, m, n and t are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease.
    Type: Grant
    Filed: September 3, 2003
    Date of Patent: October 3, 2006
    Assignee: Boehringer Ingelheim Pharmaceuticals Inc.
    Inventors: Antonio Jose del Moral Barbosa, Jr., Daniel R. Goldberg, Abdelhakim Hammach, Pingrong Liu, Neil Moss, Mark Stephen Ralph, Gregory Paul Roth, Christopher Ronald Sarko, Fariba Soleymanzadeh, Andre White
  • Apparatus for automated synthesis
    Patent number: 6991766
    Abstract: Disclosed is an apparatus for automated synthesis containing a shaker deck with a plurality of reaction blocks containing a plurality of reaction wells, an arm containing an array of extending units capable of actuating physical steps along a plurality of axes of each reaction block, each reaction block being situated on a turntable, each turntable being further capable of rotating the reaction block along a central axis. Also disclosed are methods of preparing a peptide, oligonucleotide an small molecules using the apparatus.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: January 31, 2006
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Gregory Paul Roth, Roy Lewis Barr, Junefredo Fajardo Apon, Steven Russell Bush, Thomas James Baiga
  • Substituted benzimidazole compounds
    Patent number: 6825219
    Abstract: Disclosed are substituted benzimidazole compounds of formula(I): wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention are useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: November 5, 2002
    Date of Patent: November 30, 2004
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Charles Cywin, Jinbo Lee, Steven S. Pullen, Gregory Paul Roth, Christopher Ronald Sarko, Roger John Snow, Noel Stewart Wilson
  • Heterocyclic compounds
    Publication number: 20040192748
    Abstract: Disclosed are benzimidazolone compounds of formulas (I) & (II): 1
    Type: Application
    Filed: September 3, 2003
    Publication date: September 30, 2004
    Applicant: Boehringer Ingelheim Parmaceuticals, Inc.
    Inventors: Antonio Jose del Moral Barbosa, Daniel R. Goldberg, Abdelhakim Hammach, Pingrong Liu, Neil Moss, Mark Stephen Ralph, Gregory Paul Roth, Christoper Ronald Sarko, Fariba Soleymanzadeh, Andre White
  • Compounds useful in treating cytokine mediated diseases
    Publication number: 20030225053
    Abstract: Disclosed are amide compounds of formula(I): 1
    Type: Application
    Filed: April 10, 2003
    Publication date: December 4, 2003
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Donghong Amy Gao, Daniel R. Goldberg, Abdelhakim Hammach, Ming-Hong Hao, Victor Marc Kamhi, Neil Moss, Kevin Chungeng Qian, Gregory Paul Roth, Christopher Ronald Sarko, Alan David Swinamer, Zhaoming Xiong
  • Substituted benzimidazole compounds
    Publication number: 20030144281
    Abstract: Disclosed are substituted benzimidazole compounds of formula(I): 1
    Type: Application
    Filed: November 5, 2002
    Publication date: July 31, 2003
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Charles Cywin, Jinbo Lee, Steven S. Pullen, Gregory Paul Roth, Christopher Ronald Sarko, Roger John Snow, Noel Stewart Wilson