Patents by Inventor Gregory R. BLUEMLING

Gregory R. BLUEMLING has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N4-hydroxycytidine and derivatives and anti-viral uses related thereto
    Patent number: 11903959
    Abstract: This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections, such as Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infection with the disclosed compounds.
    Type: Grant
    Filed: September 2, 2021
    Date of Patent: February 20, 2024
    Assignee: Emory University
    Inventors: George R. Painter, Gregory R. Bluemling, Michael G. Natchus, David Guthrie
  • Pharmaceutical compositions comprising substituted nucleotides and nucleosides for treating viral infections
    Patent number: 11857560
    Abstract: This disclosure relates therapeutic compositions containing a compound of Formula Im: or a pharmaceutically acceptable salt thereof, wherein R1 is as defined herein.
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: January 2, 2024
    Assignee: Emory University
    Inventors: Dennis C Liotta, George R. Painter, Gregory R. Bluemling, Abel de la Rosa
  • N4-Hydroxycytidine and Derivatives and Anti-Viral Uses Related Thereto
    Publication number: 20230293566
    Abstract: This disclosure related to N4-hydroxycytidine derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment and prophylaxis of viral infections.
    Type: Application
    Filed: March 15, 2023
    Publication date: September 21, 2023
    Inventors: George R. Painter, David Guthrie, Gregory R. Bluemling, Michael G. Natchus
  • N4-hydroxycytidine and derivatives and anti-viral uses related thereto
    Patent number: 11628181
    Abstract: This disclosure relates to N4-hydroxycytidine derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment and prophylaxis of viral infections.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: April 18, 2023
    Assignee: Emory University
    Inventors: George R. Painter, David Guthrie, Gregory R. Bluemling, Michael G. Natchus
  • NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO
    Publication number: 20220296626
    Abstract: This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.
    Type: Application
    Filed: October 27, 2021
    Publication date: September 22, 2022
    Inventors: Dennis C. Liotta, George R. Painter, Gregory R. Bluemling, Abel de la Rosa
  • Phosphoramidates for the treatment of hepatitis B virus
    Patent number: 11447518
    Abstract: Disclosed are compounds to the treatment of infectious diseases and methods of treating such diseases. The compounds are derivatives of clevudine.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: September 20, 2022
    Assignee: Emory University
    Inventors: Abel de la Rosa, Gregory R. Bluemling
  • PHOSPHORAMIDATES FOR THE TREATMENT OF HEPATITIS B VIRUS
    Publication number: 20220280542
    Abstract: Disclosed are compounds and compositions to the treatment of infectious diseases and methods of treating such diseases. The compounds and compositions include derivatives of clevudine. The compounds and compositions include derivatives of clevudine in combination with another antiviral agent. The compounds and compositions include derivatives of clevudine in combination with a phosphoramnidate of lamivudine, adefovir, tenofovir, telbivudine, entecavir, or combinations thereof.
    Type: Application
    Filed: May 6, 2022
    Publication date: September 8, 2022
    Inventors: Abel DE LA ROSA, George PAINTER, Gregory R. BLUEMLING
  • Phosphoramidates for the treatment of hepatitis B virus
    Patent number: 11364257
    Abstract: Disclosed are compounds and compositions to the treatment of infectious diseases and methods of treating such diseases. The compounds and compositions include derivatives of clevudine. The compounds and compositions include derivatives of clevudine in combination with another antiviral agent. The compounds and compositions include derivatives of clevudine in combination with a phosphoramidate of lamivudine, adefovir, tenofovir, telbivudine, entecavir, or combinations thereof.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: June 21, 2022
    Assignee: Emory University
    Inventors: Abel De La Rosa, George Painter, Gregory R. Bluemling
  • N4-hydroxycytidine and derivatives and anti-viral uses related thereto
    Patent number: 11331331
    Abstract: This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections, such as Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infection with the disclosed compounds.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: May 17, 2022
    Assignee: Emory University
    Inventors: George R. Painter, Gregory R. Bluemling, Michael G. Natchus, David Guthrie
  • N4-HYDROXYCYTIDINE AND DERIVATIVES AND ANTI-VIRAL USES RELATED THERETO
    Publication number: 20220016153
    Abstract: This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections, such as Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infection with the disclosed compounds.
    Type: Application
    Filed: September 2, 2021
    Publication date: January 20, 2022
    Inventors: George R. PAINTER, Gregory R. Bluemling, Michael G. Natchus, David Guthrie
  • PHOSPHORAMIDATES FOR THE TREATMENT OF HEPATITIS B VIRUS
    Publication number: 20210395290
    Abstract: Disclosed are compounds to the treatment of infectious diseases and methods of treating such diseases. The compounds are derivatives of clevudine.
    Type: Application
    Filed: August 2, 2021
    Publication date: December 23, 2021
    Inventors: Abel de la Rosa, Gregory R. Bluemling
  • N4-hydroxycytidine and derivatives and anti-viral uses related thereto
    Patent number: 11197882
    Abstract: This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections, such as Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infection with the disclosed compounds.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: December 14, 2021
    Assignee: Emory University
    Inventors: George R. Painter, Gregory R. Bluemling, Michael G. Natchus, David Guthrie
  • Substituted nucleotides and nucleosides for treating viral infections
    Patent number: 11166973
    Abstract: This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating viral infections, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: November 9, 2021
    Assignee: Emory University
    Inventors: Dennis C. Liotta, George R. Painter, Gregory R. Bluemling, Abel de la Rosa
  • N4-hydroxycytidine and derivatives and anti-viral uses related thereto
    Patent number: 11147826
    Abstract: This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections, such as Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infection with the disclosed compounds.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: October 19, 2021
    Assignee: Emory University
    Inventors: George R. Painter, Gregory R. Bluemling, Michael G. Natchus, David Guthrie
  • 4'-HALOGEN CONTAINING NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO
    Publication number: 20210308168
    Abstract: Disclosed are halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections. Such viral infections can include tongaviridae, bunyaviridae, arenaviridae, coronaviridae, flaviviridae, picornaviridae, Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infections.
    Type: Application
    Filed: March 7, 2019
    Publication date: October 7, 2021
    Inventors: George R. PAINTER, David PERRYMAN, Gregory R. BLUEMLING
  • N4-HYDROXYCYTIDINE AND DERIVATIVES AND ANTI-VIRAL USES RELATED THERETO
    Publication number: 20210252033
    Abstract: This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of human coronavirus 2019-nCoV.
    Type: Application
    Filed: February 8, 2021
    Publication date: August 19, 2021
    Inventors: George R. PAINTER, Gregory R. BLUEMLING, Michael C. NATCHUS, Shuli MAO, Jose MARENGO, Michael W. HAGER, David PERRYMAN
  • N4-Hydroxycytidine and Derivatives and Anti-Viral Uses Related Thereto
    Publication number: 20210060050
    Abstract: This disclosure relates to N4-hydroxycytidine derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment and prophylaxis of viral infections.
    Type: Application
    Filed: July 6, 2020
    Publication date: March 4, 2021
    Inventors: George R. Painter, David Guthrie, Gregory R. Bluemling, Michael G. Natchus
  • N4-hydroxycytidine and derivatives and anti-viral uses related thereto
    Patent number: 10874683
    Abstract: This disclosure relates to certain N4-hydroxycytidine derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of a Zika virus infection.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: December 29, 2020
    Assignee: Emory University
    Inventors: George R. Painter, David B. Guthrie, Gregory R. Bluemling, Michael R. Natchus
  • PHOSPHORAMIDATES FOR THE TREATMENT OF HEPATITIS B VIRUS
    Publication number: 20200299320
    Abstract: Disclosed are compounds to the treatment of infectious diseases and methods of treating such diseases. The compounds are derivatives of clevudine.
    Type: Application
    Filed: April 29, 2020
    Publication date: September 24, 2020
    Inventors: Abel de la Rosa, Gregory R. Bluemling
  • N4-HYDROXYCYTIDINE AND DERIVATIVES AND ANTI-VIRAL USES RELATED THERETO
    Publication number: 20200276219
    Abstract: This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections, such as Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infection with the disclosed compounds.
    Type: Application
    Filed: December 7, 2018
    Publication date: September 3, 2020
    Inventors: George R. PAINTER, Gregory R. BLUEMLING, Michael G. NATCHUS, David GUTHRIE