Abstract: A continuous rotating annular electrophoresis column for the separation of chemical mixtures. The principle of separation is similar to the conventional electrophoresis; however, it is different in that the electric field is applied in the axial direction and the column is rotated. By rotating the column, the product path appears as helical bands, each with a characteristic, stationary exit point at some angular coordinate at the bottom of the column. By applying the electric field axially, the bed thickness can be kept thin for effective heat transfer and temperature control. The apparatus can be used in the separations of biochemically active compounds, or to separate, based on the principal of charge, any chemical mixture. The column can also be packed with chromographic materials and thus operate as a electrochromographic separator.