Abstract: The present invention provides a mucoadhesive patch for attachment to a mucosal surface in a patient, the patch comprising a fibrous polymeric mat substrate and a plurality of polymeric flock particles that are attached to the substrate.

Abstract: The present invention provides a mucoadhesive patch for attachment to a mucosal surface in a patient, the patch comprising a fibrous polymeric mat substrate and a plurality of polymeric flock particles that are attached to the substrate.

Abstract: The invention provides a nanoindentation pen in the form of a device for measurement of mechanical properties of a tissue in a subject, the device comprising a dumbbell comprising an elongated shaft, the shaft being affixed at a first end to a pen tip for contacting the tissue, the shaft being affixed at a second opposite end to a terminal member, a linear actuator, and one or more pressure sensors that are in physical communication with the terminal member, the pressure sensor(s) generating a signal that indicates a force exerted on the terminal member by the pen tip via the shaft. In some embodiments, the inventive device uses statics and mechanics to calculate the stiffness of a human vocal fold based on a known displacement and a measured force. The pen tip is able to reach most sides of the vocal fold, making it ideal for all types of examination purposes.