Abstract: Polypeptides, such as antibody molecules and TCR molecules, and methods of making the same, are disclosed. The polypeptides can be used to treat, prevent, and/or diagnose disorders.

Abstract: A method includes moving a stabilization device comprising a stabilization surface relative to a base of a surgical cart, wherein the moving comprises moving the stabilization device from a retracted position in which the stabilization surface is spaced from the ground surface to a deployed position in which the stabilization surface is in contact with the ground surface, and wherein the moving comprises overcoming a biasing force biasing the stabilization device toward the retracted position.

Abstract: The invention provides polynucleotides, vectors and viruses expressing frataxin and methods of treating Friedreich's Ataxia.

Abstract: A bumper holder may attach or clamp to a variety of types of personal watercraft (PWC) to provide a bumper. The bumper holder may be used to hold the PWC in place regardless whether the PWC is docked or in use. The bumper holder does not require being near a dock/pier or piling to be used. The bumper holder may have a clamp that may connect to a PWC. The clamp may be affixed to a first bar that may be attached to a second bar using a hinge portion. The second bar may include the bumper at the end opposite the hinge portion. The bumper holder may include a lock bar that may connect and secure a top portion of the first bar to the second bar. The first bar and the second bar may be telescopic and/or adjustable.

Abstract: A natural cleaning and herbicide composition having an quaternary ammonium compound, one or more additional amine-based surfactants, and an herbicidally active limonene component, that synergistically creates an effective COVID-19 disinfectant in wipes, an effective clearer for bulk cleaning applications, as well as an impressive gross soils remover following EPA protocol. The composition may further contain sodium silicate, tetrasodium iminodisuccinate, an ethanolamine, caustic potash, and/or water. A formulation of the present disclosure comprises a mixture of about 74% soft water, about 1% Tetrasodium Iminodisuccinate, about 0.5% Monoethanolamine, about 0.5% Sodium Silicate, about 2% alkali surfactant, about 12% Ethoxylated Amine, about 1% Amine Oxide, about 1% Quaternary Amine, and about 6% Limonene.

Abstract: The invention provides polynucleotides, vectors and viruses expressing frataxin and methods of treating Friedreich's Ataxia.

Abstract: A bumper holder may attach or clamp to a variety of types of personal watercraft (PWC) to provide a bumper. The bumper holder may be used to hold the PWC in place regardless whether the PWC is docked or in use. The bumper holder does not require being near a dock/pier or piling to be used. The bumper holder may have a clamp that may connect to a PWC. The clamp may be affixed to a first bar that may be attached to a second bar using a hinge portion. The second bar may include the bumper at the end opposite the hinge portion. The bumper holder may include a lock bar that may connect and secure a top portion of the first bar to the second bar. The first bar and the second bar may be telescopic and/or adjustable.

Abstract: The invention provides polynucleotides, vectors and viruses expressing frataxin and methods of treating Friedreich's Ataxia.

Abstract: A system and method for distributing color-coded dilution ratios of cleaning concentrates at different dilution ratios and flow rates. The system mixes a concentrated cleaning composition with different quantities of water to produce diluted concentrates. A plurality of separate dyes or scented dyes are added to the diluted concentrates, with each color of dye correlating to a unique diluted concentrate. This provides a visual indication of the dilution ratio of the diluted concentrate. A plurality of metering devices selectively dispense the dyed diluted concentrates at different dilution ratios and at multiple flow rates. The metering devices are labeled with identification markings, indicating dilution ratios and flow rates. The dilution ratio and the flow rate are selected based on the type of cleaning that is required, and the type of dispensing means used for cleaning. A plurality of lines carry the concentrated cleaning composition, water, dyes, and dyed diluted concentrate.

Abstract: A system and method for distributing color-coded dilution ratios of cleaning concentrates at different dilution ratios and flow rates. The system mixes a concentrated cleaning composition with different quantities of water to produce diluted concentrates. A plurality of separate dyes or scented dyes are added to the diluted concentrates, with each color of dye correlating to a unique diluted concentrate. This provides a visual indication of the dilution ratio of the diluted concentrate. A plurality of metering devices selectively dispense the dyed diluted concentrates at different dilution ratios and at multiple flow rates. The metering devices are labeled with identification markings, indicating dilution ratios and flow rates. The dilution ratio and the flow rate are selected based on the type of cleaning that is required, and the type of dispensing means used for cleaning. A plurality of lines carry the concentrated cleaning composition, water, dyes, and dyed diluted concentrate.

Abstract: An anchoring device may be arranged above or below a body of water and may secure or anchor watercraft to at least one vertical object and/or horizontally-positioned object. The anchoring device may provide a clamping mechanism that may secure the anchoring device to the at least one vertical object and/or horizontally-positioned object. The anchoring device may be integrated or fixed to watercraft, such as at a seat pedestal. The anchoring device also may be used without being integrated or fixed to watercraft.

Abstract: A polynucleotide comprising a nucleotide sequence encoding the retinitis pigmentosa GTPase regulator ORF15 isoform (RPGRORF15) wherein the RPGRORF15 encoding nucleotide sequence has been codon optimised to increase fidelity of replication and wherein the sequence comprises one or more nucleotides selected from: C at the position corresponding to position 1968 of SEQ ID NO: 2, A at the position corresponding to position 2088 of SEQ ID NO: 2, and C at the position corresponding to position 2205 of SEQ ID NO: 2.

Abstract: The embodiments herein are directed to a reusable frameless vehicle roof-top carrier configured, dimensioned and arranged to securely mount and carry cargo loads having a size and shape similar to cut evergreen trees, while protecting the vehicle finish and cargo from damage. The reusable vehicle roof-top carrier is trapezoidal shaped to conveniently bind and condense branches of the tree, while catching sap drippings. Illustratively, the vehicle roof-top carrier is made from a tear-resistant fabric and includes a non-tacky non-slip surface placed in slip-resistant contact with the roof of the vehicle so as to prevent slippage (i.e., movement) of the tree during transport.

Abstract: An anchoring device may be arranged above or below a body of water and may secure or anchor watercraft to at least one vertical object and/or horizontally-positioned object. The anchoring device may provide a clamping mechanism that may secure the anchoring device to the at least one vertical object and/or horizontally-positioned object. The anchoring device may be integrated or fixed to watercraft, such as at a seat pedestal. The anchoring device also may be used without being integrated or fixed to watercraft.

Abstract: The embodiments herein are directed to a reusable frameless vehicle roof-top carrier configured, dimensioned and arranged to securely mount and carry cargo loads having a size and shape similar to cut evergreen trees, while protecting the vehicle finish and cargo from damage. The reusable vehicle roof-top carrier is trapezoidal shaped to conveniently bind and condense branches of the tree, while catching sap drippings. Illustratively, the vehicle roof-top carrier is made from a tear-resistant fabric and includes a non-tacky non-slip surface placed in slip-resistant contact with the roof of the vehicle so as to prevent slippage (i.e., movement) of the tree during transport.

Abstract: The invention provides polynucleotides, vectors and viruses expressing frataxin and methods of treating Friedreich's Ataxia.

Abstract: A method and a system of online shopping using a digital storefront.

Abstract: A method and a system of online shopping using a digital storefront. For example, a digital storefront having multiple touchscreen display surfaces presents a plurality of tiles to a user, where one or more tiles display images of items for sale and at least one hunch question which may be related to the environment. In further examples, a response is received from the user to one or more hunch questions, and items are recommended for the user and presented to the user in one or more updated tiles on a touchscreen display surface.

Abstract: The embodiments herein are directed to a reusable frameless vehicle roof-top carrier configured, dimensioned and arranged to securely mount and carry cargo loads having a size and shape similar to cut evergreen trees, while protecting the vehicle finish and cargo from damage. The reusable vehicle roof-top carrier is trapezoidal shaped to conveniently bind and condense branches of the tree, while catching sap drippings. Illustratively, the vehicle roof-top carrier is made from a tear-resistant fabric and includes a non-tacky non-slip surface placed in slip-resistant contact with the roof of the vehicle so as to prevent slippage (i.e., movement) of the tree during transport.

Abstract: A method and a system of online shopping using a digital storefront. For example, a digital storefront having multiple touchscreen display surfaces presents a plurality of tiles to a user, where one or more tiles display images of items for sale and at least one hunch question which may be related to the environment. In further examples, a response is received from the user to one or more hunch questions, and items are recommended for the user and presented to the user in one or more updated tiles on a touchscreen display surface.