Patents by Inventor Gregory ROSOCHA

Gregory ROSOCHA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process to make highly substituted indenes using metal salt catalysts
    Patent number: 10526262
    Abstract: According to embodiments described in the specification, a chemical process includes the steps of reacting a chemical reaction fluid including a solvent, 1,2-biaryl gem-dibromocyclopropane or 1,2-biphenyl-gem-dibromocyclopropane, and a metal salt including a silver tetrafluoroborate salt at low temperatures to make 1-phenyl-2-bromo indenes in a vessel that is capable of being closed.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: January 7, 2020
    Inventor: Gregory Rosocha
  • Process to make non nucleosidal reverse transcriptase inhibitors (NNRTI) for the treatment of HIV
    Patent number: 10017479
    Abstract: A chemical process that can form pharmaceutically acceptable medicaments NNRTI's for the treatment of HIV starting from thiotriazole compounds. The chemical process can form thiotetrazoles such as 2-((1-(naphthalen-1-yl)-1H-tetrazol-5-yl)thio)-N-(2-nitrophenyl)actetamide that is. a potent NNRTI with nanomolar activity.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: July 10, 2018
    Inventor: Gregory Rosocha
  • Cross coupling of 2-bromo-1-phenyl indenes with phenyl acetylenes and other substituted acetylenes in water
    Patent number: 9932283
    Abstract: The cross-coupling reaction of 2-bromo-1-phenyl indenes with phenyl acetylenes or propargyl alcohol is disclosed. The cross-coupling reaction uses a palladium catalyst with triphenylphosphine in the absence of a copper co-catalyst. The reaction is carried out with pyrrolidine as the base in water at 120° C.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: April 3, 2018
    Inventor: Gregory Rosocha
  • Synthesis of tetrahydroisoquinolines from 2-methyl-1-phenyl substituted indenes
    Patent number: 9902699
    Abstract: A procedure for the synthesis of tetrahydroisoquinolines from 2-methyl-1-phenyl substituted indene is described. The process involves the use of osmium tetroxide to cleave the indene double bond forming the keto aldehyde product, which is then combined with a substituted amine forming the substituted isoquinoline. Isoquinolines can be useful as industrial products in the chemical, agrochemical, oil and gas industry, as well as useful as medicaments in the pharmaceutical industry.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: February 27, 2018
    Assignee: Gregory Rosocha
    Inventor: Gregory Rosocha
  • New Process to make non nucleosidal reverse transcriptase inhibitors (NNRTI) for the treatment of HIV
    Publication number: 20160130238
    Abstract: A chemical process that can form pharmaceutically acceptable medicaments NNRTI's for the treatment of HIV starting from thiotriazole compounds. The chemical process can form thiotetrazoles such as 2-((1-(naphthalen-1-yl)-1H-tetrazol-5-yl) thio)-N-(2-nitrophenyl)actetamide that is, a potent NNRTI with nanomolar activity.
    Type: Application
    Filed: August 2, 2013
    Publication date: May 12, 2016
    Inventor: Gregory ROSOCHA
  • THE SYNTHESIS OF TETRAHYDROISOQUINOLINES FROM 2-METHYL-1-PHENYL SUBSTITUTED INDENES
    Publication number: 20150284332
    Abstract: A procedure for the synthesis of tetrahydroisoquinolines from 2-methyl-1-phenyl substituted indene is described. The process involves the use of osmium tetroxide to cleave the indene double bond forming the keto aldehyde product, which is then combined with a substituted amine forming the substituted isoquinoline. Isoquinolines can be useful as industrial products in the chemical, agrochemical, oil and gas industry, as well as useful as medicaments in the pharmaceutical industry.
    Type: Application
    Filed: October 24, 2012
    Publication date: October 8, 2015
    Inventor: Gregory ROSOCHA
  • PROCESS TO MAKE HIGHLY SUBSTITUTED INDENES USING METAL SLAT CATALYSTS
    Publication number: 20150274617
    Abstract: The present invention is a process to make 1-aryl-2-bromo substituted indenes and 1-phenyl-2-bromo substituted indenes that can have different functional groups present around the indene ring and/or the aromatic and/or phenyl ring. The indenes are made using the corresponding 1,2-biaryl-gem-dibromocyclopropane and/or 1,2-biphenyl-gem-dibromocyclopropanes and/or 1-aryl-2-phenyl-gem-dibromocyclopropanes using a metal salts, a solvent, low temperatures.
    Type: Application
    Filed: October 24, 2012
    Publication date: October 1, 2015
    Inventor: Gregory ROSOCHA