Abstract: The disclosure provides a multi-layered cell culture vessel having a rectangular shape with a top a bottom sides and ends, where the sides are longer than the ends. The vessel has hand grips and ports at each end of the rectangular vessel. The ports allow fluid entering into the vessel to flow into the multiple cell culture layers through a manifold. The ports may be incorporated into the hand grips.

Abstract: The disclosure provides a multi-layered cell culture vessel having a rectangular shape with a top a bottom sides and ends, where the sides are longer than the ends. The vessel has hand grips and ports at each end of the rectangular vessel. The ports allow fluid entering into the vessel to flow into the multiple cell culture layers through a manifold. The ports may be incorporated into the hand grips.

Abstract: A valve comprising an inlet housing, an outlet housing, an elastomeric valve element having a generally dome-shaped configuration with a central integral stem positioned substantially concentrically therewith, the inlet housing and outlet housing being fastened together at a joint with the elastomeric valve element positioned therein and the valve element including a plurality of longitudinal ribs formed along an outer annular periphery of a lower end of the dome-shaped configuration that define flow channels that allow fluid flow from across an upper surface of the dome-shaped configuration through the flow channels.

Abstract: A valve comprising an inlet housing, an outlet housing, an elastomeric valve element having a generally dome-shaped configuration with a central integral stem positioned substantially concentrically therewith, the inlet housing and outlet housing being fastened together at a joint with the elastomeric valve element positioned therein and the valve element including a plurality of longitudinal ribs formed along an outer annular periphery of a lower end of the dome-shaped configuration that define flow channels that allow fluid flow from across an upper surface of the dome-shaped configuration through the flow channels.

Abstract: A reflux valve engageable with corresponding structure, such as with another corresponding valve or instrument. The reflux valve includes an actuator which is located in, and shiftable in, a valve body. When the corresponding structure is engaged with the actuator, the actuator shifts in the valve body, and pushes a valve stem out of engagement with a valve seat. As a result, liquid is allowed to flow, in one direction, through the actuator, past the valve seat, along an area adjacent a periphery of the valve stem, and out the valve body. Preferably, when the valve stem is unseated from the valve seat, liquid can also flow in an opposite direction, i.e. along an area adjacent a periphery of the valve stem, past the valve seat, through the actuator, and out the valve body. Preferably, a spring or an extended end portion of the valve stem biases the valve stem into the valve seat.