Patents by Inventor Gregory S. Kelner

Gregory S. Kelner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human G protein-coupled receptor and modulators thereof for the treatment of cell death-related disorders
    Patent number: 7776558
    Abstract: The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In certain embodiments, the GPCR is human. In certain embodiments, the GPCR is expressed endogenously by neuronal cells or muscle cells. In certain embodiments, the GPCR is neuroprotective or myoprotective. In certain embodiments, the GPCR is a Humanin receptor. The present invention also relates to methods of using a modulator of the GPCR. A preferred modulator is agonist. Agonists of the invention are useful as therapeutic agents for the prevention or treatment of neurodegenerative diseases in general, including Alzheimer's disease, Parkinson's disease, prion-associated disease, stroke and motor-neuron disease in particular, peripheral neuropathy, cerebral amyloid beta-protein angiopathy, and ischemic heart disease, including myocardial infarction and congestive heart failure.
    Type: Grant
    Filed: March 15, 2004
    Date of Patent: August 17, 2010
    Assignee: Arena Pharmaceuticals, Inc.
    Inventors: Sonia Villegas, Gregory S. Kelner, David J. Unett, Joel Gatlin
  • Human G Protein-Coupled Receptor and Modulators Thereof for the Treatment of Cell Death-Related Disorders
    Publication number: 20080125491
    Abstract: The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In certain embodiments, the GPCR is human. In certain embodiments, the GPCR is expressed endogenously by neuronal cells or muscle cells. In certain embodiments, the GPCR is neuroprotective or myoprotective. In certain embodiments, the GPCR is a Humanin receptor. The present invention also relates to methods of using a modulator of said GPCR. A preferred modulator is agonist. Agonists of the invention are useful as therapeutic agents for the prevention or treatment of neurodegenerative diseases in general, including Alzheimer's disease, Parkinson's disease, prion-associated disease, stroke and motor-neuron disease in particular, peripheral neuropathy, cerebral amyloid beta-protein angiopathy, and ischemic heart disease, including myocardial infarction and congestive heart failure.
    Type: Application
    Filed: March 15, 2004
    Publication date: May 29, 2008
    Applicant: ARENA PHARMACEUTICALS, INC.
    Inventors: Sonia Villegas, Gregory S. Kelner, David J. Unett, Joel Gatlin
  • Method of inducing calcium flux in cells using mammalian thymokine protein
    Patent number: 6245329
    Abstract: Nucleic acids encoding a thymokine from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 12, 2001
    Assignee: Schering Corporation
    Inventors: Gregory S. Kelner, Jacqueline L. Kennedy, Albert Zlotnik
  • Antibodies which specifically bind to the thymokine lymphotactin
    Patent number: 5985580
    Abstract: Nucleic acids encoding a thymokine designated lymphotactin from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 16, 1999
    Assignee: Schering Corporation
    Inventors: Gregory S. Kelner, Jacqueline L. Kennedy, Albert Zlotnik
  • Mammalian thymokine having leukocyte chemotactic activity, and fragments thereof
    Patent number: 5877285
    Abstract: Nucleic acids encoding a thymokine from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 2, 1999
    Assignee: Schering Corporation
    Inventors: Gregory S. Kelner, Jacqueline L. Kennedy, Albert Zlotnik
  • Mammalian thymokine genes
    Patent number: 5786210
    Abstract: Nucleic acids encoding a thymokine from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
    Type: Grant
    Filed: October 25, 1994
    Date of Patent: July 28, 1998
    Assignee: Schering Corporation
    Inventors: Gregory S. Kelner, Jacqueline L. Kennedy, Albert Zlotnik