Abstract: Various methods and devices are provided for allowing multiple surgical instruments to be inserted into sealing elements of a single surgical access device. The sealing elements can be movable along predefined pathways within the device to allow surgical instruments inserted through the sealing elements to be moved laterally, rotationally, angularly, and vertically relative to a central longitudinal axis of the device for ease of manipulation within a patient's body while maintaining insufflation.

Abstract: The present invention relates to Polycyclic Guanine Derivatives, compositions comprising the Polycyclic Guanine Derivatives and methods of using the Polycyclic Guanine Derivatives to treat pain or an inflammatory disease.

Abstract: The present invention relates to Polycyclic Guanine Derivatives, compositions comprising the Polycyclic Guanine Derivatives and methods of using the Polycyclic Guanine Derivatives to treat pain or an inflammatory disease.

Abstract: A conversion press (20) which is readily reconfigurable to process shells of different sizes includes an endless belt (68) having a single lane of apertures (86) formed therein for transporting shells (S) along a progression of end-forming tooling (60, 62) comprising seven stations (58a-g) along an end path (59) through the press. A tab-forming tooling path (100) extends from a tab stock feeder (104) to a tab-staking station (58f) adjacent the discharge end of the press, the tab-forming path oriented at an oblique angle to the end path. The tab-forming tools (94, 96) are mounted on tab bases (112, 110) which are slidably adjustable on stationary and reciprocating press members (34, 44) along the tab path toward and away from the tab-staking station.

Abstract: An endless metal belt (26) for transporting shells (S) through a press (10) which converts the shells into can ends includes a plurality of shell-carrying apertures (32) and a plurality of drive holes (34). The belt is mounted about a pair of spaced-apart cylindrical drums (22,24), at least one of which is rotatably driven. The drive holes are engaged by drive pins (46) extending outwardly from the drive drum (22). Rotation of the drive drum causes the pins to engage the drive holes and advance the belt with the drum. Each drive hole has a hub (58) which is shaped to conform generally to a tapered and contoured edge (48) of a drive pin. At least a portion of the hub protrudes out of the planar surface (56) of the belt, and the pin edge and the lower surface (62) of the hub are mutually shaped to define rolling contact therebetween with no contact between the pin edge and the inner edge (54) of the drive hole.