Patents by Inventor Gregory S. Schultz

Gregory S. Schultz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rapid bed-side measurement of neutrophil elastase activity in biological fluids
    Patent number: 10577639
    Abstract: The subject invention provides novel devices and methods for the detection and quantification of neutrophil elastase activity in biological samples.
    Type: Grant
    Filed: June 28, 2010
    Date of Patent: March 3, 2020
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Gregory S. Schultz, Daniel J. Gibson
  • Materials and methods for assessing and mapping microbes and microbial biofilms on wounds
    Patent number: 9927438
    Abstract: The subject invention provides point-of-care assays for assessing the topographical distribution of microbial biofilm and/or specific microorganisms in wounds.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: March 27, 2018
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventors: Gregory S. Schultz, Edith Marion Sampson, Priscilla Lorraine Phillips
  • Materials and Methods for Assessing and Mapping Microbes and Microbial Biofilms on Wounds
    Publication number: 20160025724
    Abstract: The subject invention provides point-of-care assays for assessing the topographical distribution of microbial biofilm and/or specific microorganisms in wounds.
    Type: Application
    Filed: September 9, 2015
    Publication date: January 28, 2016
    Inventors: Gregory S. SCHULTZ, Edith Marion SAMPSON, Priscilla Lorraine PHILLIPS
  • Materials and methods for assessing and mapping microbes and microbial biofilms on wounds
    Patent number: 9145574
    Abstract: The subject invention provides point-of-care assays for assessing the topographical distribution of microbial biofilm and/or specific microorganisms in wounds.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: September 29, 2015
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Gregory S. Schultz, Priscilla Lorraine Phillips, Edith Marion Sampson
  • Materials and methods for measuring nitric oxide levels in biological fluids
    Patent number: 8906693
    Abstract: The subject invention presides novel devices and methods for the measurement of nitric oxide in biological samples, including wound fluid samples. These advantageous devices and methods can be used for clinicians to monitor the wound's nitric oxide metabolism and/or response to treatment.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: December 9, 2014
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Gregory S. Schultz, Daniel J. Gibson
  • Method and device for electromotive delivery of macromolecules into tissue
    Patent number: 8838229
    Abstract: Electromotive delivery of macromolecules can be provided using a delivery device including a first chamber for contacting a macromolecule delivery medium to a surface of a tissue or other anatomy of a patient; and a second chamber for contacting a receiving medium to the patient. A first electrode can be disposed in the first chamber so as to not directly contact the macromolecule delivery medium. A second medium having a buffering agent can be used to keep the first electrode from coming into direct contact with the macromolecule delivery medium. A second electrode can be disposed within the receiving medium in the second chamber such that the second electrode does not directly contact the patient. An electric field can be generated using the first and second electrodes in order to cause the macromolecule delivery medium to move into the tissue of interest from the first chamber of the delivery device.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: September 16, 2014
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Daniel J. Gibson, Sonal S. Tuli, Gregory S. Schultz
  • Devices for the detection of the presence and/or activity of proteases in biological samples
    Patent number: 8551764
    Abstract: The subject invention provides novel devices and methods for the detection of the presence and/or activity of proteases in biological samples.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: October 8, 2013
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Gregory S. Schultz, John I. Azeke, Daniel J. Gibson, Priscilla Lorraine Phillips, Weihong Tan, Christopher D. Batich
  • Materials and Methods for Assessing and Mapping Microbes and Microbial Biofilms on Wounds
    Publication number: 20120322048
    Abstract: The subject invention provides point-of-care assays for assessing the topographical distribution of microbial biofilm and/or specific microorganisms in wounds.
    Type: Application
    Filed: April 26, 2010
    Publication date: December 20, 2012
    Inventors: Gregory S. Schultz, Priscilla Lorraine Phillips, Edith Marion Sampson
  • MATERIALS AND METHODS FOR MEASURING NITRIC OXIDE LEVELS IN BIOLOGICAL FLUIDS
    Publication number: 20120136054
    Abstract: The subject invention presides novel devices and methods for the measurement of nitric oxide in biological samples, including wound fluid samples. These advantageous devices and methods can be used for clinicians to monitor the wound's nitric oxide metabolism and/or response to treatment.
    Type: Application
    Filed: June 3, 2010
    Publication date: May 31, 2012
    Inventors: Gregory S. Schultz, Daniel J. Gibson
  • Rapid Bed-Side Measurement of Neutrophil Elastase Activity in Biological Fluids
    Publication number: 20120135443
    Abstract: The subject invention provides novel devices and methods for the detection and quantification of neutrophil elastase activity in biological samples.
    Type: Application
    Filed: June 28, 2010
    Publication date: May 31, 2012
    Inventors: Gregory S. Schultz, Daniel J. Gibson
  • NOVEL DEVICES FOR THE DETECTION OF THE PRESENCE AND/OR ACTIVITY OF PROTEASES IN BIOLOGICAL SAMPLES
    Publication number: 20120122133
    Abstract: The subject invention provides novel devices and methods for the detection of the presence and/or activity of proteases in biological samples
    Type: Application
    Filed: November 15, 2011
    Publication date: May 17, 2012
    Inventors: Gregory S. Schultz, John I. Azeke, Daniel J. Gibson, Olajompo B. Moloye, Priscilla Lorraine Phillips, Weihong Tan, Christopher D. Batich
  • METHOD AND DEVICE FOR ELECTROMOTIVE DELIVERY OF MACROMOLECULES INTO TISSUE
    Publication number: 20120078162
    Abstract: Electromotive delivery of macromolecules can be provided using a delivery device including a first chamber for contacting a macromolecule delivery medium to a surface of a tissue or other anatomy of a patient; and a second chamber for contacting a receiving medium to the patient. A first electrode can be disposed in the first chamber so as to not directly contact the macromolecule delivery medium. A second medium having a buffering agent can be used to keep the first electrode from coming into direct contact with the macromolecule delivery medium. A second electrode can be disposed within the receiving medium in the second chamber such that the second electrode does not directly contact the patient. An electric field can be generated using the first and second electrodes in order to cause the macromolecule delivery medium to move into the tissue of interest from the first chamber of the delivery device.
    Type: Application
    Filed: May 4, 2010
    Publication date: March 29, 2012
    Applicant: University of Florida Research Foundation Inc.
    Inventors: Daniel J. Gibson, Sonal S. Tuli, Gregory S. Schultz
  • Devices for the detection of the presence and/or activity of proteases in biological samples
    Patent number: 8058024
    Abstract: The subject invention provides novel devices and methods for the detection of the presence and/or activity of proteases in biological samples.
    Type: Grant
    Filed: December 15, 2008
    Date of Patent: November 15, 2011
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Gregory S. Schultz, John I. Azeke, Daniel J. Gibson, Olajompo B. Moloye, Priscilla Lorraine Phillips, Weihong Tan, Christopher D. Batich
  • Herpesvirus ribozymes and vectors
    Patent number: 7838659
    Abstract: Hammerhead ribozymes that target components critical to HSV replication (ICP4, UL20, UL30, and UL54) were synthesized and shown to efficiently cleave target RNA encoding a portion of these components in in vitro assays. Several cloned cell lines stably expressing these ribozymes were established. HSV-mediated plaque formation was dramatically reduced in cells stably transfected with an anti-HSV ribozyme compared to non-transfected cells.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: November 23, 2010
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Alfred S. Lewin, David C. Bloom, Gregory S. Schultz, Sonal Sanjeev Tuli, Jia Liu
  • Novel devices for the detection of the presence and/or activity of proteases in biological samples
    Publication number: 20090258382
    Abstract: The subject invention provides novel devices and methods for the detection of the presence and/or activity of proteases in biological samples.
    Type: Application
    Filed: December 15, 2008
    Publication date: October 15, 2009
    Inventors: Gregory S. Schultz, John I. Azeke, Daniel J. Gibson, Olajompo B. Moloye, Priscilla Lorraine Phillips, Weihong Tan, Christopher D. Batich
  • HERPESVIRUS RIBOZYMES AND VECTORS
    Publication number: 20090131644
    Abstract: Hammerhead ribozymes that target components critical to HSV replication (ICP4, UL20, UL30, and UL54) were synthesized and shown to efficiently cleave target RNA encoding a portion of these components in in vitro assays. Several cloned cell lines stably expressing these ribozymes were established. HSV-mediated plaque formation was dramatically reduced in cells stably transfected with an anti-HSV ribozyme compared to non-transfected cells.
    Type: Application
    Filed: February 25, 2008
    Publication date: May 21, 2009
    Inventors: Alfred S. Lewin, David C. Bloom, Gregory S. Schultz, Sonal Sanjeev Tuli, Jia Liu
  • Anti-scarring ribozymes and methods
    Patent number: 7462602
    Abstract: Methods and compositions for treating scarring conditions associated with increased expression of connective tissue growth factor (CTGF). Aspects of the invention include ribozymes that cleave mRNA targets required for CTGF expression, cells containing anti-CTGF ribozymes and vectored anti-CTGF ribozymes suitable for delivery to cellular targets capable of CTGF expression.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: December 9, 2008
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Gregory S. Schultz, Alfred S. Lewin, Timothy D. Blalock
  • Anti-scarring ribozymes and methods
    Publication number: 20040235031
    Abstract: Methods and compositions for treating scarring conditions associated with increased expression of connective tissue growth factor (CTGF). Aspects of the invention include ribozymes that cleave mRNA targets required for CTGF expression, cells containing anti-CTGF ribozymes and vectored anti-CTGF ribozymes suitable for delivery to cellular targets capable of CTGF expression.
    Type: Application
    Filed: April 30, 2004
    Publication date: November 25, 2004
    Inventors: Gregory S. Schultz, Alfred S. Lewin, Timothy D. Blalock
  • Methods and compositions for treatment of otitis media
    Publication number: 20040175383
    Abstract: The invention is directed to the treatment of otitis media by administration of protease inhibitors. In some embodiments, the protease inhibitors are alpha one-antitrypsin and/or ilomastat.
    Type: Application
    Filed: December 8, 2003
    Publication date: September 9, 2004
    Inventors: Philip J. Barr, Philip A. Pemberton, Patrick J. Antonelli, Gregory S. Schultz, David J. Sundin
  • Medical use of matrix metalloproteinase inhibitors for inhibiting tissue contraction
    Patent number: 6759432
    Abstract: The use of an MMP inhibitor, especially a collagenase inhibitor, in the manufacture of a medicament for the treatment of a natural or artificial tissue comprising extracellular matrix components to inhibit contraction of the tissue and methods for the treatment of tissue comprising extracellular matrix components to inhibit contraction.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: July 6, 2004
    Assignees: University of Florida Research Foundation, Moorfields Eye Hospital National Health Service Trust, The Institute of Ophthalmology
    Inventors: Peng Tee Khaw, Gregory S. Schultz