Abstract: Systems and methods for inspecting seals for leaks are disclosed herein. In a general embodiment, the present disclosure provides a seal inspection system including: a closure threadingly attached to a container, each of the closure and the container including a mark; at least one camera positioned to detect the mark on the closure and the mark on the container; and a computer including a processor configured to calculate at least one of 1) an angle between the mark on the container and the mark on the closure, or 2) a distance between the mark on the container and the mark on the closure and determine whether the angle or the distance meets a reference value.