Abstract: The invention provides compounds, and methods of using those compounds to treat neurodegenerative diseases.

Abstract: A method of inhibiting propagation of protein misfolding associated with a neurological disease, is carried out by contacting an environment populated with a propagating amyloid conformation of a protein (prion) associated with a neurological disease with molecules which binds multiple adjacent sites of the protein assemblies and allowing the molecules to bind multiple cites of the protein assemblies; and thereby impeding propagation of the disease-associated conformation of the protein in the environment. Drug/prion complexes are formed and uses of the drugs in detection and treatment of neurodegenerative diseases are disclosed.

Abstract: A method for detecting a neurological disease the method comprising isolating brain tissue from its natural environment, contacting the brain tissue with a labeled molecule which binds to multiple sites of stacked proteins associated with neurodegenerative disease, determining the binding of the labeled molecule; and thereby determining a neurodegenerative disease associated with the brain tissue.

Abstract: Example implementations involve systems and methods to advance data acquisition systems for automated visual inspection using a mobile camera infrastructure. The example implementations address the uncertainty of localization and navigation under semi-controlled environments. The approach combines object detection models and navigation planning to control the quality of visual inputs in the inspection process. The solution guides the operator (human or robot) to collect only valid viewpoints to achieve higher accuracy. Finally, the learning models and navigation planning are generalized to multiple type and size of inspection objects.