Abstract: The present invention relates to materials and methods suitable for determining the presence or amount of Botulinum toxin (BoNT) in a test sample by means of a luminescence assay in which the substrate peptide is composed of: an amino acid sequence susceptible to proteolytic cleavage by BoNT, an amino acid sequence corresponding to a reporter domain encoding a fluorescent or bioluminescent polypeptide, and a tag suitable for attaching the substrate peptide to a suitable support, preferably by covalent bond.

Abstract: The present invention relates to a method of determining Botulinum toxin (BoNT) based on a luminescence assay. The present application further relates to a peptide that is susceptible to proteolytic cleavage by BoNT which is suitable for that method.

Abstract: Methods, computer programs, and information handling systems for modeling one or more reservoirs are disclosed. The method uses one or more well logs, each for a well at a location and each including one or more Relative amount of Small Size Range of the Size Spectrum of Clastic Particles (RSSRSS) values versus depth. The method includes for one or more well logs: identifying one or more facies units based on RSSRSS values, determining a thickness of one or more facies units. The method includes determining a facies type of one or more facies units, categorizing one or more facies units, and connecting one or more facies units to create a reservoir model.

Abstract: A method for modeling fluid depletion in a reservoir is disclosed. A map is divided into cells. For each of the cells a value is stored that is based at least in part on a physical characteristic of the cell. At least one cell that contains a depletion location is identified along with a depletion amount corresponding to that location. An amount of walkers associated with the depletion location is determined. For each walker, a plurality of steps are calculated with each step to an adjacent cell. Each walker starts in the cell containing the depletion location associated with that walker. The visits of all the walkers are recorded by cell. The fluid depletion of each cell is then assessed based at least in part on the number of walker visits for each cell.

Abstract: The invention relates to methods for characterizing the cardiotoxicity of an agent.