Abstract: This invention provides methods for treating or preventing kidney diseases and fibrosis, such as chronic kidney disease (CKD), kidney fibrosis, heart fibrosis, uterine fibrosis, and cystic fibrosis, with compounds of Formulae (I), (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof.

Abstract: Various embodiments include a trapped vortex combustor and a method for operating trapped vortex combustor. In one embodiment, the trapped vortex combustor comprises a trapped vortex combustion zone and at least one secondary combustion zone disposed downstream of the trapped vortex combustion zone. The trapped vortex combustion zone is operable to receive and combust a first fuel and a first air and produce a first combustion product flowing toroidally therein. The at least one secondary combustion zone is operable to receive and combust the first combustion product and at least one second injection consisting of fuel and/or air and produce at least one second combustion product therein. The combustor may reduce the residence time of the highest temperature combustion products and achieve the lower NOx emission.

Abstract: The invention relates to a loading head arrangement (1, 5, 15), including a telescopic loading head (5) for loading pourable bulk materials (6) onto railway cars (20), wherein the loading head (5) sealingly rests on a filling opening (11) arranged at the railway car (20) by way of at least one seal (25, 26), and wherein the seal (25, 26) is designed as a double seal and has a first upper sealing ring (25), which rests on a horizontal flange (11a) of the filling opening (11), and a second lower sealing ring (26), which sealingly conforms to a vertical flange (11b) of the filling opening (11).

Abstract: Systems and methods for generating a video of a user-defined virtual reality scene are disclosed. Exemplary implementations may: obtain a scene definition; obtain camera information for multiple virtual cameras to be used in generating a two-dimensional presentation of the virtual reality scene; execute a simulation of the virtual reality scene from the scene definition for at least a portion of the scene duration; obtain camera timing instructions specifying which of the virtual cameras should be used to generate the two-dimensional presentation of the virtual reality scene as a function of progress through the scene duration; generate the two-dimensional presentation of the virtual reality scene in accordance with the camera timing instructions and the camera information.

Abstract: Various embodiments include a trapped vortex combustor and a method for operating trapped vortex combustor. In one embodiment, the trapped vortex combustor comprises a trapped vortex combustion zone and at least one secondary combustion zone disposed downstream of the trapped vortex combustion zone. The trapped vortex combustion zone is operable to receive and combust a first fuel and a first air and produce a first combustion product flowing toroidally therein. The at least one secondary combustion zone is operable to receive and combust the first combustion product and at least one second injection consisting of fuel and/or air and produce at least one second combustion product therein. The combustor may reduce the residence time of the highest temperature combustion products and achieve the lower NOx emission.

Abstract: A combination microwave and refrigerator system is provided. The microwave oven is connected to a source of power and has at least one control circuit for controlling the operation of the microwave oven. A first power supply outlet is provided on the microwave oven. A refrigerator is connected to the source of power by connection to the first power supply outlet. The control circuit is configured to disable the cooling operation of the refrigerator, when the microwave oven demands cooking power, and enable the cooling operation of the refrigerator when the microwave oven is not drawing cooking power. A sensor is provided in the microwave oven, and is configured to cause cooking power to the microwave oven to be turned off upon the sensor sensing a level of smoke.

Abstract: This invention relates to an airway dilation device comprising a catheter; an inflation tube within the catheter, and having a lumen defined by its inner wall; a duct within the catheter, for the insufflation of a fluid, the duct being sealed against any fluid flow between it and the tube; a cluster of balloons, arranged about the catheter, the balloons being manipulated between a stowed condition, in which the balloons are deflated, and a deployed condition, in which the balloons are inflated; and inflating means, for inflating the balloons; characterised in that, when stowed, each balloon is folded and staggered relative to each adjacent balloon, and such that continuous insufflation remains possible, even when deployed. This invention relates, further, to corresponding methods of deployment of devices.

Abstract: The present invention relates to a process for removing dry surface biofilm from a surface. The process comprises: (i) dissolving a powder-based composition into water wherein the powder-based composition comprises: a) a hydrogen peroxide source, b) an acetyl donor, c) an acidifying agent, and d) a wetting agent; (ii) allowing the solution to generate a biocidally effective concentration of peracetic acid; (iii) contacting the dry surface biofilm contaminated surface with the solution of peracetic acid for a period of time; and (iv) removing the solution.

Abstract: The invention provides compounds, compositions and methods for treating medical disorders, such as cancer, an autoimmune disorder, and/or a neurological disorder, and inhibiting LINE1 reverse transcriptase and/or HERV-K reverse transcriptase using a compound according to Formula I or a pharmaceutically acceptable salt thereof, or a related compound provided herein.

Abstract: The invention provides compounds, compositions and methods for treating medical disorders, such as cancer, an autoimmune disorder, and/or a neurological disorder, and inhibiting LINE1 reverse transcriptase and/or HERV-K reverse transcriptase using a compound according to Formula I or a pharmaceutically acceptable salt thereof, or a related compound provided herein.

Abstract: A biofilm disrupting composition for use on chronic wounds comprising (i) at least one biologically acceptable thiol based antioxidant (ii) at least one biofilm disruptor and (iii) at least one biocide. Also disclosed is a process of preparing the composition. Also disclosed is the use of the composition for the manufacture of a medicament for the treatment of a chronic wound, and a method of treating a chronic wound in a patient comprising administering the biofilm disrupting composition.

Abstract: Provided is an electrochemical reaction method that includes: immersing an anode and a cathode into a solution that includes azide ion (N3?), an alkene, and a transition metal catalyst; passing a current through the anode; and forming a diazide from the alkene. Related systems are also provided.

Abstract: The present invention provides acoustic sensor systems and methods for detecting acoustic information from a human or animal subject. An acoustic sensor system of the disclosure herein detects acoustic information and generates an analog electric signal corresponding to the information that is highly accurate.

Abstract: A working disinfectant solution comprising peracetic acid and at least one surfactant, prepared by the dilution of either a single-part or two-part concentrate for use in the disinfection or sterilisation of reusable medical devices such as endoscopes. The working solution exhibits rapid wetting characterised by a dynamic surface tension of less than 50 mN/m at 250 ms and 46 mN/m at 500 ms.

Abstract: A flat-screen display wall mount cover protects exposed cables and equipment behind a television or other mounted monitor. The apparatus is configured to be selectively permeable with respect to infrared signals and heat, while being impermeable to dust or harmful airborne particles. The apparatus includes a first flexible crossbar, a second flexible crossbar, a first display-bracing rod, a second display-bracing rod, a first wall-bracing rod, a second wall-bracing rod, and an opaque fabric cover. The first flexible crossbar and the second flexible crossbar are preferably hollow cylindrical units which support and arrangement the opaque fabric cover. Tension from the flexible crossbars allows the apparatus to conform to varying spaces behind a mounted monitor. The display-bracing rods support and position the opaque fabric cover by pressing against a monitor or television. The wall-bracing rods support and position the opaque fabric cover by pressing against the adjacent wall.

Abstract: A biofilm disrupting composition for use on chronic wounds comprising (i) at least one biologically acceptable thiol based antioxidant(ii) at least one biofilm disruptor and (iii) at least one biocide. Also disclosed is a process of preparing the composition. Also disclosed is the use of the composition for the manufacture of a medicament for the treatment of a chronic wound, and a method of treating a chronic wound in a patient comprising administering the biofilm disrupting composition.

Abstract: A biofilm disrupting composition for use in treating biofilm-mediated infections due to non-Pseudomonas micro-organisms in the Cystic Fibrosis patient. One embodiment of the composition of the invention comprises at least one biologically acceptable thiol based antioxidant and at least one antibiotic. Another embodiment of the composition of the invention comprises at least one biologically acceptable thiol based antioxidant, at least one enzyme and at least one antibiotic. The invention is also directed to the process of preparing the composition of the invention, the use of the composition for the manufacture of a medicament for disrupting biofilms formed by non-Pseudomonad micro-organisms, and a method of disrupting biofilm formed by non-Pseudomonad micro-organisms in a patient, comprising administering to the patient the composition of the invention.

Abstract: Provided is an electrochemical reaction method that includes: immersing an anode and a cathode into a solution that includes azide ion (N3?), an alkene, and a transition metal catalyst; passing a current through the anode; and forming a diazide from the alkene. Related systems are also provided.

Abstract: A flat-screen display wall mount cover protects exposed cables and equipment behind a television or other mounted monitor. The apparatus is configured to be selectively permeable with respect to infrared signals and heat, while being impermeable to dust or harmful airborne particles. The apparatus includes a first flexible crossbar, a second flexible crossbar, a first display-bracing rod, a second display-bracing rod, a first wall-bracing rod, a second wall-bracing rod, and an opaque fabric cover. The first flexible crossbar and the second flexible crossbar are preferably hollow cylindrical units which support and arrangement the opaque fabric cover. Tension from the flexible crossbars allows the apparatus to conform to varying spaces behind a mounted monitor. The display-bracing rods support and position the opaque fabric cover by pressing against a monitor or television. The wall-bracing rods support and position the opaque fabric cover by pressing against the adjacent wall.

Abstract: Piecewise smooth regularization of data is disclosed. One example is a system where input data is received, the input data being associated with a certainty function indicative of confidence of each data element in the input data. Guide data including information indicative of presumed piecewise smoothness of the input data is received. A joint edge-aware filter is applied, based on the guide data, to the input data to provide filtered data. The joint edge-aware filter is applied, based on the guide data, to the certainty function to provide filtered certainty. A normalized convolution algorithm is applied to the filtered data and the filtered certainty to provide output data indicative of a piecewise smooth regularization of the input data.