Patents by Inventor Gregory T. Whiteker

Gregory T. Whiteker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12017993
    Abstract: Methods for preparing 5-fluoro-6-(bromo or chloro)picloram analogs, or derivatives thereof, from picloram acid, picloram ester, or the nitrile analog of picloram are provided. The methods include chemical process steps that: (1) introduce a phthaloyl group onto the 4-amino substituent of picloram acid, picloram ester, or the nitrile analog of picloram, (2) add 2 fluorine atoms at the 5,6-positions of the pyridine ring using halex fluorination chemistry, (3) remove the phthaloyl group, hydrolyze the ester or nitrile substituent, and add chlorine or bromine to the 6-position by treatment with an acid and water, and finally, (4) esterify the 5-fluoro-6-(bromo or chloro)picloram acid produced in step (3) to a 5-fluoro-6-(bromo or chloro)picloram ester.
    Type: Grant
    Filed: June 23, 2022
    Date of Patent: June 25, 2024
    Assignee: CORTEVA AGRISCIENCE LLC
    Inventors: Jayachandran Devaraj, Nugzar Ghavtadze, Nicholas M. Irvine, Jeremy Kister, Melissa Lee, Ronald B. Leng, Rongrong [Mandy] Lin, Rong Ling, Noormohamed M. Niyaz, Abraham D. Schuitman, Aaron A. Shinkle, Siyu Tu, Gregory T. Whiteker, Chunming Zhang
  • Publication number: 20230357155
    Abstract: The present disclosure relates to improved processes for preparing 4-amino-6-(heterocyclic)picolinates.
    Type: Application
    Filed: March 17, 2021
    Publication date: November 9, 2023
    Applicant: CORTEVA AGRISCIENCE LLC
    Inventors: BELGIN CANTURK, JAYACHANDRAN DEVARAJ, AMARUKA HAZARI, CHRISTOPHER KASSL, MELISSA LEE, FANGZHENG LI, CHRISTIAN T. LOWE, THOMAS L. SIDDALL, GREGORY T. WHITEKER, CHUNMING ZHANG
  • Publication number: 20220411375
    Abstract: The present technology relates to processes, mixtures and intermediates useful for making picolinamide fungicides. The picolinamide compounds are prepared by processes that include coupling together a 4-methoxy-3-acyloxypicolinic acid with key 2-amino-L-alaninate esters derived from substituted 2-phenylethanols.
    Type: Application
    Filed: October 15, 2020
    Publication date: December 29, 2022
    Applicant: CORTEVA AGRISCIENCE LLC
    Inventors: NICHOLAS R. BABIJ, ELIZABETH O. MCCUSKER, GREGORY T. WHITEKER, NEERAJ SANE, SIYU TU, XIAOYONG LI, DANIEL W. KLOSOWSKI, PATRICK T. MCGOUGH, MENG GUO, MATTHEW ROBINSON, JEFFREY SCOTT NISSEN, TYLER DAVIS, YAN HAO
  • Publication number: 20220371997
    Abstract: Methods for preparing 5-fluoro-6-(bromo or chloro)picloram analogs, or derivatives thereof, from picloram acid, picloram ester, or the nitrile analog of picloram are provided. The methods include chemical process steps that: (1) introduce a phthaloyl group onto the 4-amino substituent of picloram acid, picloram ester, or the nitrile analog of picloram, (2) add 2 fluorine atoms at the 5,6-positions of the pyridine ring using halex fluorination chemistry, (3) remove the phthaloyl group, hydrolyze the ester or nitrile substituent, and add chlorine or bromine to the 6-position by treatment with an acid and water, and finally, (4) esterify the 5-fluoro-6-(bromo or chloro)picloram acid produced in step (3) to a 5-fluoro-6-(bromo or chloro)picloram ester.
    Type: Application
    Filed: June 23, 2022
    Publication date: November 24, 2022
    Applicant: CORTEVA AGRISCIENCE LLC
    Inventors: JAYACHANDRAN DEVARAJ, NUGZAR GHAVTADZE, NICHOLAS M. IRVINE, JEREMY KISTER, MELISSA LEE, RONALD B. LENG, RONGRONG [MANDY] LIN, RONG LING, NOORMOHAMED M. NIYAZ, ABRAHAM D. SCHUITMAN, AARON A. SHINKLE, SIYU TU, GREGORY T. WHITEKER, CHUNMING ZHANG
  • Patent number: 11401242
    Abstract: Methods for preparing 5-fluoro-6-(bromo or chloro)picloram analogs, or derivatives thereof, from picloram acid, picloram ester, or the nitrile analog of picloram are provided. The methods include chemical process steps that: (1) introduce a phthaloyl group onto the 4-amino substituent of picloram acid, picloram ester, or the nitrile analog of picloram, (2) add 2 fluorine atoms at the 5,6-positions of the pyridine ring using halex fluorination chemistry, (3) remove the phthaloyl group, hydrolyze the ester or nitrile substituent, and add chlorine or bromine to the 6-position by treatment with an acid and water, and finally, (4) esterify the 5-fluoro-6-(bromo or chloro)picloram acid produced in step (3) to a 5-fluoro-6-(bromo or chloro)picloram ester.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: August 2, 2022
    Assignee: Corteva Agriscience LLC
    Inventors: Jayachandran Devaraj, Nugzar Ghavtadze, Nicholas M. Irvine, Jeremy Kister, Melissa Lee, Ronald B. Leng, Rongrong [Mandy] Lin, Rong Ling, Noormohamed M. Niyaz, Abraham D. Schuitman, Aaron A. Shinkle, Siyu Tu, Gregory T. Whiteker, Chunming Zhang
  • Publication number: 20210323923
    Abstract: Methods for preparing 5-fluoro-6-(bromo or chloro)picloram analogs, or derivatives thereof, from picloram acid, picloram ester, or the nitrile analog of picloram are provided. The methods include chemical process steps that: (1) introduce a phthaloyl group onto the 4-amino substituent of picloram acid, picloram ester, or the nitrile analog of picloram, (2) add 2 fluorine atoms at the 5,6-positions of the pyridine ring using halex fluorination chemistry, (3) remove the phthaloyl group, hydrolyze the ester or nitrile substituent, and add chlorine or bromine to the 6-position by treatment with an acid and water, and finally, (4) esterify the 5-fluoro-6-(bromo or chloro)picloram acid produced in step (3) to a 5-fluoro-6-(bromo or chloro)picloram ester.
    Type: Application
    Filed: September 18, 2019
    Publication date: October 21, 2021
    Applicant: Corteva Agriscience LLC
    Inventors: Jayachandran Devaraj, Nugzar Ghavtadze, Nicholas M. Irvine, Jeremy Kister, Melissa Lee, Ronald B. Leng, Rongrong [Mandy] Lin, Rong Ling, Noormohamed M. Niyaz, Abraham D. Schuitman, Aaron A. Shinkle, Siyu Tu, Gregory T. Whiteker, Chunming Zhang
  • Patent number: 10550083
    Abstract: 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction that are conducted as a single pot process. 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: February 4, 2020
    Assignee: Dow AgroSciences LLC
    Inventors: Kenneth E. Stockman, Gregory T. Whiteker, Erich J. Molitor, Nakyen Choy
  • Patent number: 10358423
    Abstract: A fungicidal 4-methoxy-3-acetyloxypicolinamide may be conveniently prepared in processes that include the coupling together of 4-methoxy-3-acetyloxypicolinic acid or 4-methoxy-3-hydroxypicolinic acid with a key 2-aminopropanoate ester derived from a 1,1-bis(4-fluorophenyl)propane-1,2-diol.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: July 23, 2019
    Assignee: Dow AgroSciences LLC
    Inventors: Gregory T. Whiteker, Nakyen Choy, Peter Borromeo, Nicholas R. Babij, Gary Roth, Patrick S. Hanley, Matthias S. Ober, Tina Staton, Daniel I. Knueppel, Grant Von Wald, Nicole Hough
  • Publication number: 20190112271
    Abstract: 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction that are conducted as a single pot process. 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement.
    Type: Application
    Filed: January 23, 2017
    Publication date: April 18, 2019
    Inventors: Kenneth E. STOCKMAN, Gregory T. WHITEKER, Erich J. MOLITOR, Nakyen CHOY
  • Patent number: 10259789
    Abstract: 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction that are conducted as a single pot process. 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement. 4-Alkoxy-3-acetoxypicolinic acids may be conveniently prepared from 4-alkoxy-3-hydroxypicolinic acids by treatment with acetic anhydride.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: April 16, 2019
    Inventors: Gregory T. Whiteker, Peter Borromeo, Fangzheng Li, Gary Roth
  • Publication number: 20190047962
    Abstract: 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction that are conducted as a single pot process. 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement. 4-Alkoxy-3-acetoxypicolinic acids may be conveniently prepared from 4-alkoxy-3-hydroxypicolinic acids by treatment with acetic anhydride.
    Type: Application
    Filed: January 23, 2017
    Publication date: February 14, 2019
    Inventors: Gregory T. WHITEKER, Peter BORROMEO, Fangzheng LI, Gary ROTH
  • Publication number: 20180319750
    Abstract: A fungicidal 4-methoxy-3-acetyloxypicolinamide may be conveniently prepared in processes that include the coupling together of 4-methoxy-3-acetyloxypicolinic acid or 4-methoxy-3-hydroxypicolinic acid with a key 2-aminopropanoate ester derived from a 1,1-bis(4-fluorophenyl)propane-1,2-diol.
    Type: Application
    Filed: July 16, 2018
    Publication date: November 8, 2018
    Applicant: Dow AgroSciences LLC
    Inventors: Gregory T. Whiteker, Nakyen Choy, Peter Borromeo, Nicholas R. Babij, Gary Roth, Patrick S. Hanley, Matthias S. Ober, Tina Staton, Daniel I. Knueppel, Grant Von Wald, Nicole Hough
  • Patent number: 10040764
    Abstract: A fungicidal 4-methoxy-3-acetyloxypicolinamide may be conveniently prepared in processes that include the coupling together of 4-methoxy-3-acetyloxypicolinic acid or 4-methoxy-3-hydroxypicolinic acid with a key 2-aminopropanoate ester derived from a 1,1-bis(4-fluorophenyl)propane-1,2-diol.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: August 7, 2018
    Assignee: Dow AgroSciences LLC
    Inventors: Gregory T. Whiteker, Nakyen Choy, Peter Borromeo, Nicholas R. Babij, Gary Roth, Patrick S. Hanley, Matthias S. Ober, Tina Staton, Daniel I. Knueppel, Grant Von Wald, Nicole Hough
  • Patent number: 10035772
    Abstract: A fungicidal 4-methoxy-3-acetyloxypicolinamide may be conveniently prepared in processes that include the coupling together of 4-methoxy-3-acetyloxypicolinic acid or 4-methoxy-3-hydroxypicolinic acid with a key 2-aminopropanoate ester derived from a 1,1-bis(4-fluorophenyl)propane-1,2-diol.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: July 31, 2018
    Assignee: Dow AgroSciences LLC
    Inventors: Gregory T. Whiteker, Nakyen Choy, Peter Borromeo, Nicholas R. Babij
  • Patent number: 9981911
    Abstract: 4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: May 29, 2018
    Assignee: Dow AgroSciences LLC
    Inventors: James M. Renga, Gregory T. Whiteker, Peter Lee Johnson, Christopher Galliford
  • Patent number: 9951018
    Abstract: 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 2-hydroxypicolinonitrile in a series of chemical steps selected from chlorination, chloro substitution, nitrile hydrolysis and chloro reduction.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: April 24, 2018
    Assignee: Dow AgroSciences LLC
    Inventors: Patrick S. Hanley, Nakyen Choy, Thomas L. Siddall, Gregory T. Whiteker
  • Publication number: 20180009756
    Abstract: A fungicidal 4-methoxy-3-acetyloxypicolinamide may be conveniently prepared in processes that include the coupling together of 4-methoxy-3-acetyloxypicolinic acid or 4-methoxy-3-hydroxypicolinic acid with a key 2-aminopropanoate ester derived from a 1,1-bis(4-fluorophenyl)propane-1,2-diol.
    Type: Application
    Filed: July 6, 2017
    Publication date: January 11, 2018
    Applicant: Dow AgroSciences LLC
    Inventors: Gregory T. Whiteker, Nakyen Choy, Peter Borromeo, Nicholas R. Babij
  • Publication number: 20180009755
    Abstract: A fungicidal 4-methoxy-3-acetyloxypicolinamide may be conveniently prepared in processes that include the coupling together of 4-methoxy-3-acetyloxypicolinic acid or 4-methoxy-3-hydroxypicolinic acid with a key 2-aminopropanoate ester derived from a 1,1-bis(4-fluorophenyl)propane-1,2-diol.
    Type: Application
    Filed: July 6, 2017
    Publication date: January 11, 2018
    Applicant: Dow AgroSciences LLC
    Inventors: Gregory T. Whiteker, Nakyen Choy, Peter Borromeo, Nicholas R. Babij, Gary Roth, Patrick S. Hanley, Matthias S. Ober, Tina Staton, Daniel I. Knueppel, Grant Von Wald, Nicole Hough
  • Publication number: 20170349549
    Abstract: 4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps.
    Type: Application
    Filed: August 23, 2017
    Publication date: December 7, 2017
    Applicant: Dow AgroSciences LLC
    Inventors: James M. Renga, Gregory T. Whiteker, Peter Lee Johnson, Christopher Galliford
  • Patent number: 9822077
    Abstract: 4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: November 21, 2017
    Assignee: Dow AgroSciences LLC
    Inventors: James M. Renga, Gregory T. Whiteker, Peter L. Johnson, Christopher Galliford