Patents by Inventor Gregory Thatcher

Gregory Thatcher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphono-carboxylate compounds for treating amyloidosis
    Publication number: 20080004244
    Abstract: Therapeutic compounds and methods for modulating amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group, a congener thereof, or a pharmaceutically acceptable salt or ester thereof. In preferred embodiments, an interaction between an amyloidogenic protein and a basement membrane constituent is modulated.
    Type: Application
    Filed: August 2, 2007
    Publication date: January 3, 2008
    Applicant: Neurochem (International) Limited
    Inventors: Walter Szarek, Xianqi Kong, Gregory Thatcher, Boris Gorine
  • Methods and compositions for mitigating pain
    Publication number: 20070066575
    Abstract: Methods and therapeutic compounds for treating pain, mitigating inflammation, effecting analgesia and/or effecting sedation in a subject are described. A subject is administered an effective amount of a therapeutic compound which is a nitrate ester. Novel pharmaceutical compositions are also described.
    Type: Application
    Filed: August 22, 2006
    Publication date: March 22, 2007
    Applicant: Queen's University at Kingston
    Inventors: Gregory Thatcher, Brian Bennett, James Reynolds, Khem Jhamandas
  • Phosphono-carboxylate compounds for treating amyloidosis
    Publication number: 20060135479
    Abstract: Therapeutic compounds and methods for modulating amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group, a congener thereof, or a pharmaceutically acceptable salt or ester thereof. In preferred embodiments, an interaction between an amyloidogenic protein and a basement membrane constituent is modulated.
    Type: Application
    Filed: October 7, 2005
    Publication date: June 22, 2006
    Inventors: Walter Szarek, Xianqi Kong, Gregory Thatcher, Boris Gorine
  • Nitrate esters and their use for mitigating cellular damage
    Publication number: 20050137191
    Abstract: Nitrate esters and methods for mitigating neurodegeneration, affecting neuroprotection, affecting cognition enhancement, and/or preventing or mitigating tissue and/or cellular damage in a subject are described. Neurological or cognitive conditions, or damage mediated by free radicals are treated by administering to a subject an effective amount of a therapeutic compound comprising a nitrate ester, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 17, 2004
    Publication date: June 23, 2005
    Inventors: Gregory Thatcher, Brian Bennett, James Reynolds, Roland Boegman, Khem Jhamandas
  • Per-6-substituted-per-6-deoxy-cyclodextrins, and use of the same to inhibit soluble beta-amyloid-peptide derived oligomers and to treat alzheimer's and related diseases
    Publication number: 20050059634
    Abstract: Per-6-substituted-per-6-deoxy-cyclodextrins and compositions containing the same are disclosed. The compounds and compositions inhibit the formation and/or activity of soluble ?-amyloid-peptide derived oligomers, and can be used to treat diseases and conditions wherein such inhibition is beneficial, for example, Alzheimer's disease.
    Type: Application
    Filed: July 26, 2004
    Publication date: March 17, 2005
    Inventors: Duane Venton, William Klein, Gregory Thatcher, Lei Chang, Rong Liu, Zhiqiang Wang, Mark Holterman
  • Nerve process growth modulators
    Patent number: 5834446
    Abstract: Nerve process growth modulation can be achieved using derivatized cyclodextrins. Processes for making sulfated and aminated .beta.-cyclodextrin derivatives are also described in which a compound of the formula R".sub.2 NCH X'.sup.+ X'.sup.- where R.sup.- is an alkyl containing 1-5 carbon atoms and X is selected from bromine and iodine is used to halogenate the cydodextrin.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: November 10, 1998
    Assignee: Queen's University at Kingston
    Inventors: Kimberly E. Dow, Boris I. Gorine, Richard J. Riopelle, Gregory Thatcher