Patents by Inventor Gregory Thomas Bourne

Gregory Thomas Bourne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases
    Patent number: 12673974
    Abstract: Peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease, are disclosed.
    Type: Grant
    Filed: December 1, 2023
    Date of Patent: July 7, 2026
    Assignee: Protagonist Therapeutics, Inc.
    Inventors: Ashok Bhandari, Gregory Thomas Bourne, Xiaoli Cheng, Brian Troy Frederick, Jie Zhang, Dinesh V. Patel, David Liu
  • CONJUGATED HEPCIDIN MIMETICS
    Publication number: 20250361280
    Abstract: The present invention provides peptides, which are hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: February 2, 2023
    Publication date: November 27, 2025
    Inventors: Gregory Thomas BOURNE, Ashok BHANDARI, Jie ZHANG, Mark Leslie SMYTHE
  • HEPCIDIN MIMETICS FOR TREATMENT OF SICKLE CELL DISEASE
    Publication number: 20250360187
    Abstract: The disclosure provides compositions and methods for the treatment and/or prevention of sickle cell disease.
    Type: Application
    Filed: June 6, 2023
    Publication date: November 27, 2025
    Applicant: Protagonist Therapeutics, Inc.
    Inventors: David Y. Liu, Gregory Thomas Bourne, Roopa Taranath, Li Zhao
  • HEPCIDIN ANALOGUES AND USES THEREOF
    Publication number: 20250340608
    Abstract: The present invention relates, inter alia, to certain hepcidin peptide analogues, including peptides and dimers thereof, and to the use of the peptides and peptide dimers in the treatment and/or prevention of a variety of diseases, conditions or disorders, including treatment and/or prevention of iron overload diseases, which include hereditary hemochromatosis and iron-loading anemias, and other conditions and disorders described herein.
    Type: Application
    Filed: March 4, 2025
    Publication date: November 6, 2025
    Applicant: Protagonist Therapeutics, Inc.
    Inventors: Mark Leslie Smythe, Gregory Thomas Bourne, Simone Vink, Brian Troy Frederick, Praveen Madala, Anne Pernille Tofteng Shelton, Jacob Ulrik Fog
  • CONJUGATED HEPCIDIN MIMETICS
    Publication number: 20250304624
    Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: January 13, 2025
    Publication date: October 2, 2025
    Inventors: Gregory Thomas BOURNE, Ashok BHANDARI, Brian Troy FREDERICK, Jie ZHANG, Adam STEPHENSON, Mark Leslie SMYTHE, Roopa TARANATH, David Y. LIU
  • CONJUGATED HEPCIDIN MIMETICS
    Publication number: 20250277012
    Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof. The present invention provides novel peptide analogues, including both peptide monomer analogues and peptide dimer analogues, having hepcidin activity, and also having other beneficial properties making the peptides of the present invention suitable alternatives to hepcidin.
    Type: Application
    Filed: March 31, 2022
    Publication date: September 4, 2025
    Inventors: Ashok BHANDARI, Jie ZHANG, Gregory Thomas BOURNE, Mark Leslie SMYTHE, Tran Trung TRAN, Roopa TARANATH
  • CONJUGATED HEPCIDIN MIMETICS
    Publication number: 20250170216
    Abstract: Disclosed herein are peptides or hepcidin analogues with improved in vivo half lives, and pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: February 2, 2023
    Publication date: May 29, 2025
    Inventors: Gregory Thomas BOURNE, Ashok BHANDARI, Jie ZHANG, Mark Leslie SMYTHE, Roopa TARANATH
  • Hepcidin analogues and uses thereof
    Patent number: 12269856
    Abstract: The present invention relates, inter alia, to certain hepcidin peptide analogues, including peptides and dimers thereof, and to the use of the peptides and peptide dimers in the treatment and/or prevention of a variety of diseases, conditions or disorders, including treatment and/or prevention of iron overload diseases, which include hereditary hemochromatosis and iron-loading anemias, and other conditions and disorders described herein.
    Type: Grant
    Filed: September 28, 2023
    Date of Patent: April 8, 2025
    Assignee: Protagonist Therapeutics, Inc.
    Inventors: Mark Leslie Smythe, Gregory Thomas Bourne, Simone Vink, Brian Troy Frederick, Praveen Madala, Anne Pernille Tofteng Shelton, Jacob Ulrik Fog
  • Conjugated hepcidin mimetics
    Patent number: 12234300
    Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.
    Type: Grant
    Filed: August 7, 2023
    Date of Patent: February 25, 2025
    Assignee: Protagonist Therapeutics, Inc.
    Inventors: Gregory Thomas Bourne, Ashok Bhandari, Brian Troy Frederick, Jie Zhang, Adam Stephenson, Mark Leslie Smythe, Roopa Taranath, David Y. Liu
  • Peptide Inhibitors of Interleukin-23 Receptor
    Publication number: 20240279281
    Abstract: The present disclosure relates to peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, methods and/or uses for treatment of autoimmune inflammation and related diseases and disorders.
    Type: Application
    Filed: January 15, 2024
    Publication date: August 22, 2024
    Inventors: Stephanie A. BARROS, Santhosh Francis Neelamkavil, Chengzao SUN, Boying Guo, Charles Hendrick, David Marcoux, Sandeep Somani, Tho Thieu, Jing Zhang, Danila Branca, Roberto Costante, Ashok Bhandari, Gregory Thomas Bourne, Brian Troy Frederick
  • CONJUGATED HEPCIDIN MIMETICS
    Publication number: 20240226225
    Abstract: The present invention generally relates to peptide analogues, including both monomers and dimers, exhibiting hepcidin activity with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof in the treatment and/or prevention of conditions or disorders, including erythrocytoses, such as polycytemia vera, iron overload diseases such as hereditary hemochromatosis: iron-loading anemias, and other conditions and disorders.
    Type: Application
    Filed: March 31, 2022
    Publication date: July 11, 2024
    Applicant: Protagonist Therapeutics, Inc.
    Inventors: Gregory Thomas BOURNE, Ashok BHANDARI, Mark Leslie SMYTHE
  • CONJUGATED HEPCIDIN MIMETICS
    Publication number: 20240209053
    Abstract: The present invention relates, inter alia, to certain hepcidin peptide analogues, including both peptide monomers and peptide dimers, and conjugates and derivatives thereof, as well as compositions comprising the peptide analogues, and to the use of the peptide analogues in the treatment and/or prevention of a variety of diseases, conditions or disorders, including treatment and/or prevention of erythrocytoses, such as polycytemia vera, iron overload diseases such as hereditary hemochromatosis, iron-loading anemias, and other conditions and disorders described herein.
    Type: Application
    Filed: March 31, 2022
    Publication date: June 27, 2024
    Applicant: Protagonist Therapeutics, Inc.
    Inventors: Gregory Thomas BOURNE, Ashok BHANDARI
  • CONJUGATED HEPCIDIN MIMETICS
    Publication number: 20240209024
    Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: August 7, 2023
    Publication date: June 27, 2024
    Inventors: Gregory Thomas BOURNE, Ashok BHANDARI, Brian Troy FREDERICK, Jie ZHANG, Adam STEPHENSON, Mark Leslie SMYTHE, Roopa TARANATH, David Y. LIU
  • ORAL PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY BOWEL DISEASES
    Publication number: 20240199700
    Abstract: Peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease, are disclosed.
    Type: Application
    Filed: December 1, 2023
    Publication date: June 20, 2024
    Inventors: Ashok BHANDARI, Gregory Thomas BOURNE, Xiaoli CHENG, Brian Troy FREDERICK, Jie ZHANG, Dinesh V. PATEL, David LIU
  • HEPCIDIN ANALOGUES AND USES THEREOF
    Publication number: 20240174726
    Abstract: The present invention relates, inter alia, to certain hepcidin peptide analogues, including peptides and dimers thereof, and to the use of the peptides and peptide dimers in the treatment and/or prevention of a variety of diseases, conditions or disorders, including treatment and/or prevention of iron overload diseases, which include hereditary hemochromatosis and iron-loading anemias, and other conditions and disorders described herein.
    Type: Application
    Filed: September 28, 2023
    Publication date: May 30, 2024
    Applicant: Protagonist Therapeutics, Inc.
    Inventors: Mark Leslie SMYTHE, Gregory Thomas BOURNE, Simone VINK, Brian Troy FREDERICK, Praveen MADALA, Anne Pernille TOFTENG SHELTON, Jacob Ulrik FOG
  • PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES
    Publication number: 20240150405
    Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
    Type: Application
    Filed: October 23, 2023
    Publication date: May 9, 2024
    Inventors: Chengzao SUN, Brian Troy FREDERICK, Sandeep SOMANI, Gregory Thomas BOURNE, Raymond PATCH, Ashok BHANDARI, Raffaele INGENITO, Roberto COSTANTE, Danila BRANCA, Elisabetta BIANCHI
  • PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES
    Publication number: 20240132558
    Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
    Type: Application
    Filed: January 13, 2023
    Publication date: April 25, 2024
    Inventors: Ashok BHANDARI, Gregory Thomas BOURNE
  • CONJUGATED HEPCIDIN MIMETICS
    Publication number: 20240066131
    Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: July 28, 2021
    Publication date: February 29, 2024
    Applicant: Protagonist Therapeutics, Inc.
    Inventors: Gregory Thomas BOURNE, Ashok BHANDARI, Jie ZHANG, Brian Troy FREDERICK, Mark Leslie SMYTHE
  • Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases
    Patent number: 11884748
    Abstract: Peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease, are disclosed.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: January 30, 2024
    Assignee: Protagonist Therapeutics, Inc.
    Inventors: Ashok Bhandari, Gregory Thomas Bourne, Xiaoli Cheng, Brian Troy Frederick, Jie Zhang, Dinesh V. Patel, David Liu
  • HEPCIDIN MIMETICS FOR TREATMENT OF SICKLE CELL DISEASE
    Publication number: 20240016895
    Abstract: The disclosure provides compositions and methods for the treatment and/or prevention of sickle cell disease.
    Type: Application
    Filed: July 20, 2023
    Publication date: January 18, 2024
    Inventors: David Y. LIU, Gregory Thomas BOURNE, Roopa TARANATH, Li ZHAO