Abstract: The invention relates to methods of (i) treating a subject for a disease, (ii) amelioration of decline of forced vital capacity in a subject in need thereof, (iii) modulating ?V?6 integrin, ?V?1 integrin, or both ?V?6 integrin and ?V?1 integrin in a subject in need thereof, (iv) increasing the expression of one or more genes in a subject in need thereof, (v) decreasing the expression of one or more genes in a subject in need thereof, and (vi) modulating the activity of at least one gene affecting fibrotic activity in a subject in need thereof, comprising administration of compounds of Formula (A), Formula (I), Formula (II), or (S)-4-((2-methoxyethyl)(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl)amino)-2-(quinazolin-4-ylamino)butanoic acid, or a pharmaceutically acceptable salt thereof as described herein; and administering to the subject at least a second drug selected from pirfenidone and nintedanib, or a salt thereof.

Abstract: An autonomous mobile device (AMD) builds up electrostatic charges from moving and generates heat from the operation of internal components. In addition to possible user discomfort, electrostatic discharges may damage sensors and electronics. Electrostatic charges are dissipated from the AMD using an electrostatic dissipation structure and conductive wheels. A conductive path between a chassis ground, the electrostatic dissipation structure, and the conductive wheels improves the dissipation of electrostatic charges. Electrostatic charges are also dissipated from components by mounting the components using conductive materials. Sensors may be affixed to a support structure that is affected by thermal expansion. Thermal expansion may distort precise positioning of sensors, reducing accuracy of sensor data. An elastomeric foam may be used to mount sensors to a support structure, allowing for thermal expansion without distorting the positioning of the sensors.

Abstract: An autonomous mobile device has a main body and an extensible mast to raise and lower a payload, such as a camera, relative to the main body. The mast may comprise a set of telescoping sections, with each section comprising two or more pieces that are joined during assembly. A motor moves a flexible rack between a first spool and the mast to raise or lower the mast. For example, during extension a motor-driven pinion engages teeth on the flexible rack, pulling the rack from the first spool and pushing up the mast. A cable stored on a second spool may be extended and retracted with the flexible rack. The cable transfers one or more of data or power between the main body and the payload. A sensor may be used to detect features on the flexible rack to provide data about how far the flexible rack has been extended.

Abstract: This disclosure describes a voice-controlled electronic device that includes a housing and a mounting component. The housing includes a translucent cover attached to a cylindrical-shaped unibody enclosure. The electronic device further includes a microphone array disposed near a first end within the housing, a speaker box disposed within the housing, and a printed circuit board assembly disposed within the housing. Additionally, the electronic device includes a camera disposed within the housing and attached to the printed circuit board assembly, and a depth sensor that includes a depth camera and a projector. In some instances, the camera and the depth sensor point substantially in a direction of the translucent cover. Furthermore, the electronic device includes a light ring that protrudes from a surface of the translucent display and surrounds a lens of the camera.

Abstract: This disclosure describes a voice-controlled electronic device that includes a housing and a mounting component. The housing includes a translucent cover attached to a cylindrical-shaped unibody enclosure. The electronic device further includes a microphone array disposed near a first end within the housing, a speaker box disposed within the housing, and a printed circuit board assembly disposed within the housing. Additionally, the electronic device includes a camera disposed within the housing and attached to the printed circuit board assembly, and a depth sensor that includes a depth camera and a projector. In some instances, the camera and the depth sensor point substantially in a direction of the translucent cover. Furthermore, the electronic device includes a light ring that protrudes from a surface of the translucent display and surrounds a lens of the camera.

Abstract: A modular computing system includes an electronic device and a case. The electronic device has a cavity formed by a thin portion and a thick portion. The case has an auxiliary portion that fits within the cavity of the electronic device when the electronic device is docked with the case. The electronic device has a device battery and the auxiliary portion of the case has a case battery that electronically couples with the electronic device when the electronic device is coupled to the case. The electronic device has a display assembly coupled to a cover glass, and the cover glass has two apertures providing two respective buttons within the apertures.

Abstract: This disclosure describes a voice-controlled electronic device that includes a housing and a mounting component. The housing includes a translucent cover attached to a cylindrical-shaped unibody enclosure. The electronic device further includes a microphone array disposed near a first end within the housing, a speaker box disposed within the housing, and a printed circuit board assembly disposed within the housing. Additionally, the electronic device includes a camera disposed within the housing and attached to the printed circuit board assembly, and a depth sensor that includes a depth camera and a projector. In some instances, the camera and the depth sensor point substantially in a direction of the translucent cover. Furthermore, the electronic device includes a light ring that protrudes from a surface of the translucent display and surrounds a lens of the camera.

Abstract: Described herein are electronic devices that includes a display stack having a cover component atop a lightguide component and a display component below the lightguide component. In some instances, the cover component including an antiglare etching applied to a top surface of a coverglass and a touch pattern applied to a bottom surface of the coverglass. In some cases, an optically clear adhesive layer formed from two types of optically clear adhesive may be located between the cover component and the lightguide component and a ring adhesive may be applied to around an outer edge of the cover component, the optically clear adhesive and the lightguide component.

Abstract: Describe herein are electronic devices that includes an enclosure having a flexible portion extending partially over the coverglass. In some instances, the flexible portion is configured to deform during assembly to allow the coverglass to be placed within the enclosure and to return to an original position once the assembly is complete. In other instances, the flexible portion may be configured to act as a bezel and to conceal any gap between an edge of the coverglass and a side wall of the enclosure from view.

Abstract: A side surface of a cover glass of an electronic device may be coated with a curable ink to reduce leakage of light from the side surface. The ink may be deposited on the side surface via a pen comprising a reservoir, a valve, and a nib. The nib may comprise a fiber bundle through which pigment particles may pass. The ink may be precisely deposited via the nib on the side surface without visible ink overflowing to a front surface or a back surface of the cover glass.

Abstract: Described herein are electronic devices that includes a display stack having a cover component atop a lightguide component and a display component below the lightguide component. In some instances, the cover component including an antiglare etching applied to a top surface of a coverglass and a touch pattern applied to a bottom surface of the coverglass. In some cases, an optically clear adhesive layer formed from two types of optically clear adhesive may be located between the cover component and the lightguide component and a ring adhesive may be applied to around an outer edge of the cover component, the optically clear adhesive and the lightguide component.

Abstract: An electronic device includes a stack assembly and a cover glass. The stack assembly includes an electronic paper display sub-assembly for rendering content, a front light sub-assembly for illuminating the electronic display sub-assembly, and a capacitive touch sensing sub-assembly for detecting touch inputs. The cover glass includes two apertures for the placement of control buttons for the electronic device. Prior to assembly of the electronic device, the cover glass is strengthened after the two apertures are formed so as to strengthen the interior edges of the apertures.

Abstract: An electronic device includes a stack assembly and a cover glass. The stack assembly includes an electronic paper display sub-assembly for rendering content, a front light sub-assembly for illuminating the electronic display sub-assembly, and a capacitive touch sensing sub-assembly for detecting touch inputs. The cover glass includes two apertures for the placement of control buttons for the electronic device. Prior to assembly of the electronic device, the cover glass is strengthened after the two apertures are formed so as to strengthen the interior edges of the apertures.

Abstract: A front light component for electronic devices that include displays for rendering content using a light guide to control illumination for a front light display. A high reflectivity “white” tape is used under and adjacent to the light guide to improve overall uniformity of the light beams. The high reflectivity tape may also be selected to be of a controlled white hue to compensate for variances in color of Light Emitting Diodes (LEDs) where the LED color is slightly off from ideal white. In this way the complementary color of the high reflectivity tape with the color of the LED will cause the output spectrum to be uniform and white. This disclosure also describes techniques for assembling electronic devices in a component stack to provide enhanced display uniformity and improved reading experience.

Abstract: Disclosed are compounds of Formula I wherein X, Y, R1-R7, T1, T2, Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula I and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula I; a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula I; a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula I; and a method of preparing a compound of Formula I as described herein.

Abstract: Disclosed are compounds of Formula I wherein X, Y, R1-R7, T1, T2, Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula I and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula I; a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula I; a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula I; and a method of preparing a compound of Formula I as described herein.

Abstract: Disclosed are compounds of Formula (I) wherein X, Y, Ri-R7, T1, T2, Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula (I) and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula (I); a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula (I); a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula (I); and a method of preparing a compound of Formula (I) as described herein.

Abstract: Disclosed are compounds of Formula (I) wherein X, Y, Ri-R7,T1, T2, Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula (I) and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula (I); a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula (I); a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula (I); and a method of preparing a compound of Formula (I) as described herein.

Abstract: An antenna system includes an antenna feed aligned with a subreflector and a main reflector. The subreflector has a concave surface defining a vertex. A main reflector having a concave surface is aligned with the subreflector to define an antenna focal area at the vertex of the subreflector. The antenna feed may be a phased array or fixed antenna feed. The antenna system may further include a controller cooperating with the phased array antenna feed for beamsteering or beamforming. The controller may cooperate with the phased array antenna feed to define and steer multiple beams, at different frequencies, for example.

Abstract: Automated systems and methods provide for enhanced management of components of fire safety systems. Components are identified which require action to ensure compliance with a schedule associated with the components. User and/or electronic output is generated that identifies components and required actions, such actions including inspections, functional testing, maintenance and calibration activities. A record of the identified components may be stored in a system log along with maintenance information. The system log may be reviewed against the schedule based on conformance to ordinances or maintenance requirements. Required actions may be annunciated for the identified components, and the system log may be updated to indicate actions performed on system components. Components may be identified that will require action within a predetermined timeframe and an alert or report may be generated for components that are not in compliance with their associated schedule.