Patents by Inventor Gregory Von Abendroth
Gregory Von Abendroth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10513693Abstract: The present invention relates to a process for producing an organic acid by fermentation, comprising the process steps: I) cultivating microorganisms in a culture medium to which are fed, as assimilable carbon sources, glycerol and a further carbonaceous compound, to allow the microorganisms to produce the organic acid, thereby obtaining a fermentation broth comprising the organic acid; II) recovering the organic acid or the salt thereof from the fermentation broth obtained in process step I); wherein, at least for a certain period of time in process step I), the consumption rate of the further carbonaceous compound (CRc.c.; in g per liter per hour) is lower than the maximum theoretical consumption rate of the further carbonaceous compound (CRc.c. max; in g per liter per hour).Type: GrantFiled: March 18, 2015Date of Patent: December 24, 2019Assignee: BASF SEInventors: Esther Dantas Costa, Oskar Zelder, Hartwig Schröder, Stefan Haefner, Joanna Martyna Krawczyk, Gregory Von Abendroth, Christian Riedele, Torsten Renz
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Patent number: 10287558Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the pykA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.Type: GrantFiled: February 2, 2015Date of Patent: May 14, 2019Assignee: BASF SEInventors: Joanna Martyna Krawczyk, Stefan Haefner, Hartwig Schröder, Esther Dantas Costa, Oskar Zelder, Gregory Von Abendroth, Christoph Wittmann, René Stellmacher, Judith Becker, Anna Lange, Benjamin J. Lyons, Thomas J. Lyons, Eudes De Crecy, Ewa Hughes
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Patent number: 10273485Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the wcaJ-gene. The present invention also relates to a method for producing an organic compound and to the use of a modified microorganism.Type: GrantFiled: February 6, 2015Date of Patent: April 30, 2019Assignee: BASF SEInventors: Joanna Martyna Krawczyk, Stefan Haefner, Hartwig Schröder, Esther Dantas Costa, Oskar Zelder, Gregory Von Abendroth, Christoph Wittmann, René Stellmacher, Judith Becker
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Patent number: 9932612Abstract: The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.Type: GrantFiled: April 1, 2015Date of Patent: April 3, 2018Assignee: BASF SEInventors: Hartwig Schröder, Stefan Haefner, Gregory Von Abendroth, Rajan Hollmann, Aline Raddatz, Hansgeorg Ernst, Hans Gurski
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Publication number: 20180030418Abstract: The present invention relates to a process for producing an organic acid by fermentation, comprising the process steps: I) cultivating microorganisms in a culture medium to which are fed, as assimilable carbon sources, glycerol and a further carbonaceous compound, to allow the microorganisms to produce the organic acid, thereby obtaining a fermentation broth comprising the organic acid; II) recovering the organic acid or the salt thereof from the fermentation broth obtained in process step I); wherein, at least for a certain period of time in process step I), the consumption rate of the further carbonaceous compound (CRc.c.; in g per liter per hour) is lower than the maximum theoretical consumption rate of the further carbonaceous compound (CRc.c. max; in g per liter per hour).Type: ApplicationFiled: March 18, 2015Publication date: February 1, 2018Inventors: Esther Dantas Costa, Oskar Zelder, Hartwig Schröder, Stefan Haefner, Joanna Martyna Krawczyk, Gregory Von Abendroth, Christian Riedele, Torsten Renz
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Patent number: 9850506Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the fruA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.Type: GrantFiled: May 2, 2015Date of Patent: December 26, 2017Assignee: BASF SEInventors: Joanna Martyna Krawczyk, Stefan Haefner, Hartwig Schröder, Esther Dantas Costa, Oskar Zelder, Gregory Von Abendroth
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Publication number: 20170166937Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the fruA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.Type: ApplicationFiled: May 2, 2015Publication date: June 15, 2017Inventors: Joanna Martyna Krawczyk, Stefan Haefner, Hartwig Schröder, Esther Dantas Costa, Oskar Zelder, Gregory Von Abendroth
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Publication number: 20160362696Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the wcaJ-gene. The present invention also relates to a method for producing an organic compound and to the use of a modified microorganism.Type: ApplicationFiled: February 6, 2015Publication date: December 15, 2016Inventors: Joanna Martyna Krawczyk, Stefan Haefner, Hartwig Schröder, Esther Dantas Costa, Oskar Zelder, Gregory Von Abendroth, Christoph Wittmann, René Stellmacher, Judith Becker
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Publication number: 20160348082Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the pykA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.Type: ApplicationFiled: February 2, 2015Publication date: December 1, 2016Inventors: Joanna Martyna Krawczyk, Stefan Haefner, Hartwig Schröder, Esther Dantas Costa, Oakar Zelder, Gregory von Abendroth, Christoph Wittmann, René Stellmacher, Judith Becker, Anna Lange, Benjamin J. Lyons, Thomas J. Lyons, Eudes De Crecy, Ewa Hughes
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Publication number: 20150197776Abstract: The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.Type: ApplicationFiled: April 1, 2015Publication date: July 16, 2015Applicant: BASF SEInventors: Hartwig Schröder, Stefan Haefner, Gregory Von Abendroth, Rajan Hollmann, Aline Raddatz, Hansgeorg Ernst, Hans Gurski
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Patent number: 9023632Abstract: The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.Type: GrantFiled: January 8, 2014Date of Patent: May 5, 2015Assignee: BASF SEInventors: Hartwig Schröder, Stefan Haefner, Gregory Von Abendroth, Rajan Hollmann, Aline Raddatz, Hansgeorg Ernst, Hans Gurski
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Publication number: 20140127764Abstract: The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.Type: ApplicationFiled: January 8, 2014Publication date: May 8, 2014Applicant: BASF SEInventors: Hartwig Schröder, Stefan Haefner, Gregory Von Abendroth, Rajan Hollmann, Aline Raddatz, Hansgeorg Ernst, Hans Gurski
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Patent number: 8673598Abstract: The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.Type: GrantFiled: February 12, 2010Date of Patent: March 18, 2014Assignee: BASF SEInventors: Hartwig Schroder, Stefan Haefner, Gregory Von Abendroth, Rajan Hollmann, Aline Raddatz, Hansgeorg Ernst, Hans Gurski
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Patent number: 8647824Abstract: Compositions and methods are provided that relate to the bioremediation of chlorinated ethenes, particularly the bioremediation of vinyl chloride by Dehalococcoides-like organisms. An isolated strain of bacteria, Dehalococcoides sp. strain VS, that metabolizes vinyl chloride is provided; the genetic sequence of the enzyme responsible for vinyl chloride dehalogenation; methods of assessing the capability of endogenous organisms at an environmental site to metabolize vinyl chloride; and a method of using the strains of the invention for bioremediation.Type: GrantFiled: November 11, 2011Date of Patent: February 11, 2014Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Alfred M. Spormann, Jochen A. Müller, Bettina M. Rosner, Gregory Von Abendroth, Galit Meshulam-Simon, Perry L. McCarty
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Publication number: 20120082983Abstract: Compositions and methods are provided that relate to the bioremediation of chlorinated ethenes, particularly the bioremediation of vinyl chloride by Dehalococcoides-like organisms. An isolated strain of bacteria, Dehalococcoides sp. strain VS, that metabolizes vinyl chloride is provided; the genetic sequence of the enzyme responsible for vinyl chloride dehalogenation; methods of assessing the capability of endogenous organisms at an environmental site to metabolize vinyl chloride; and a method of using the strains of the invention for bioremediation.Type: ApplicationFiled: November 11, 2011Publication date: April 5, 2012Inventors: Alfred M. Spormann, Jochen A. Muller, Bettina M. Rosner, Gregory Von Abendroth, Galit Meshulam-Simon, Perry L. McCarty
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Publication number: 20110300589Abstract: The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.Type: ApplicationFiled: February 12, 2010Publication date: December 8, 2011Applicant: BASF SEInventors: Hartwig Schroder, Stefan Haefner, Gregory Von Abendroth, Rajan Hollmann, Aline Raddatz, Hansgeorg Ernst, Hans Gurski
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Patent number: 8063192Abstract: Compositions and methods are provided that relate to the bioremediation of chlorinated ethenes, particularly the bioremediation of vinyl chloride by Dehalococcoides-like organisms. An isolated strain of bacteria, Dehalococcoides sp. strain VS, that metabolizes vinyl chloride is provided; the genetic sequence of the enzyme responsible for vinyl chloride dehalogenation; methods of assessing the capability of endogenous organisms at an environmental site to metabolize vinyl chloride; and a method of using the strains of the invention for bioremediation.Type: GrantFiled: August 2, 2005Date of Patent: November 22, 2011Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Alfred M. Spormann, Jochen A. Müller, Bettina M. Rosner, Gregory Von Abendroth, Galit Meshulam-Simon, Perry L McCarty
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Publication number: 20090176210Abstract: Compositions and methods are provided that relate to the bioremediation of chlorinated ethenes, particularly the bioremediation of vinyl chloride by Dehalococcoides-like organisms. An isolated strain of bacteria, Dehalococcoides sp. strain VS, that metabolizes vinyl chloride is provided; the genetic sequence of the enzyme responsible for vinyl chloride dehalogenation; methods of assessing the capability of endogenous organisms at an environmental site to metabolize vinyl chloride; and a method of using the strains of the invention for bioremediation.Type: ApplicationFiled: August 2, 2005Publication date: July 9, 2009Inventors: Alfred M. Spormann, Jochen A. Müller, Bettina M. Rosner, Gregory Von Abendroth, Galit Meshulam-Simon, Perry L McCarty