Abstract: Therapy systems with quantified biomarker targeting, including for epilepsy treatment, and associated systems and methods, are disclosed. A representative computer-based method for establishing epilepsy treatment parameters for a patient includes receiving multiple indications of interictal EEG biomarkers over a period of time and processing the multiple indications to produce a processed biomarker. The processed biomarker is then used to identify at least one target location at the patient's brain to receive an electrical therapy signal to reduce or eliminate epileptic activity in the patient, and at least one additional signal delivery parameter in accordance with which the electrical therapy signal is to be delivered.

Abstract: Multiscale brain electrodes can be used for spatiotemporal mapping, probing, and therapeutic modulation of the human brain. The applications for such functional mapping and electrical stimulation modulation span, for example, neurological and psychiatric diseases, and brain rehabilitation.

Abstract: Multiscale brain electrodes can be used for spatiotemporal mapping, probing, and therapeutic modulation of the human brain. The applications for such functional mapping and electrical stimulation modulation span, for example, neurological and psychiatric diseases, and brain rehabilitation.

Abstract: Therapy systems with quantified biomarker targeting, including for epilepsy treatment, and associated systems and methods, are disclosed. A representative computer-based method for establishing epilepsy treatment parameters for a patient includes receiving multiple indications of interictal EEG biomarkers over a period of time and processing the multiple indications to produce a processed biomarker. The processed biomarker is then used to identify at least one target location at the patient's brain to receive an electrical therapy signal to reduce or eliminate epileptic activity in the patient, and at least one additional signal delivery parameter in accordance with which the electrical therapy signal is to be delivered.

Abstract: Developing a measure of critical systems-like behavior in an epilepsy patient in order to map epileptic networks, either passively or evoking responses through subthreshold stimulation, and to apply “therapeutic” stimulations to the patient that cause smaller, but more frequent dissipations of “energy,” a transcription product, subclinical electrophysiological activity or seizures in order to raise the clinical seizure initiation threshold, through releasing accumulated interictal energy in a seizure onset zone or elsewhere in the epileptic network, thereby preventing occurrence of larger more debilitating seizures.