Patents by Inventor Gren Z. Wang

Gren Z. Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic Amides Useful as Protein Modulators
    Publication number: 20230071675
    Abstract: Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.
    Type: Application
    Filed: May 17, 2022
    Publication date: March 9, 2023
    Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    Inventors: Adam Kenneth CHARNLEY, Michael G DARCY, Jason W. DODSON, Xiaoyang DONG, Terry V. HUGHES, Jianxing KANG, Lara LEISTER, Yiqian LIAN, Yue LI, John F. MEHLMANN, Neysa NEVINS, Joshi M. RAMANJULU, Joseph J. ROMANO, Gren Z. WANG, Guosen YE, Daohua ZHANG
  • Heterocyclic amides useful as protein modulators
    Patent number: 11365190
    Abstract: Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.
    Type: Grant
    Filed: January 25, 2021
    Date of Patent: June 21, 2022
    Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    Inventors: Adam Kenneth Charnley, Gren Z. Wang, Joseph J. Romano
  • HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS AND METHODS OF USING THE SAME
    Publication number: 20210238172
    Abstract: The invention relates to combinations comprising a compound of the formula: or a salt thereof; and one or more additional pharmaceutically agents active against HIV, and methods of using the same.
    Type: Application
    Filed: October 4, 2018
    Publication date: August 5, 2021
    Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    Inventors: Adam Kenneth CHARNLEY, Michael Gerard DARCY, Jason W. DODSON, Xiaoyang DONG, David FAVRE, Terry Vincent HUGHES, Jianxing KANG, Lara Kathryn LEISTER, Yuehu LI, Yiqian LIAN, John F. MEHLMANN, Neysa NEVINS, Joshi M. RAMANJULU, Joseph J. ROMANO, Gren Z. WANG, Guosen YE, Daohua ZHANG
  • HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS
    Publication number: 20210139473
    Abstract: Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.
    Type: Application
    Filed: January 25, 2021
    Publication date: May 13, 2021
    Inventors: Adam Kenneth CHARNLEY, Gren Z. Wang, Joseph J. Romano
  • Amino-quinolines as kinase inhibitors
    Patent number: 10220030
    Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: March 5, 2019
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Michael Jonathan Bury, Linda N. Casillas, Adam Kenneth Charnley, Pamela A. Haile, Robert W. Marquis, Jr., John F. Mehlmann, Joseph J. Romano, Robert R. Singhaus, Jr., Gren Z. Wang
  • AMINO-QUINOLINES AS KINASE INHIBITORS
    Publication number: 20180085365
    Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.
    Type: Application
    Filed: November 14, 2017
    Publication date: March 29, 2018
    Inventors: Michael Jonathan BURY, Linda N. CASILLAS, Adam Kenneth CHARNLEY, Pamela A. HAILE, Robert W. MARQUIS, JR., John F. MEHLMANN, Joseph J. ROMANO, Robert R. SINGHAUS, JR., Gren Z. WANG
  • AMINO-QUINOLINES AS KINASE INHIBITORS
    Publication number: 20170128437
    Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.
    Type: Application
    Filed: January 24, 2017
    Publication date: May 11, 2017
    Inventors: Michael Jonathan BURY, Linda N. CASILLAS, Adam Kenneth CHARNLEY, Pamela A. HAILE, Robert W. MARQUIS, JR., John F. MEHLMANN, Joseph J. ROMANO, Robert R. SINGHAUS, JR., Gren Z. WANG
  • Amino-quinolines as kinase inhibitors
    Patent number: 9604963
    Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: March 28, 2017
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Michael Jonathan Bury, Linda N. Casillas, Adam Kenneth Charnley, Pamela A. Haile, Robert W. Marquis, Jr., John F. Mehlmann, Joseph J. Romano, Robert R. Singhaus, Jr., Gren Z. Wang
  • AMINO-QUINOLINES AS KINASE INHIBITORS
    Publication number: 20130345258
    Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.
    Type: Application
    Filed: March 2, 2012
    Publication date: December 26, 2013
    Applicant: Glaxosmithline LLC
    Inventors: Michael Jonathan Bury, Linda N. Casillas, Adam Kenneth Charnley, Pamela A. Haile, Robert W. Marquis, JR., John F. Mehlmann, Joseph J. Romano, Robert R. Singhaus, JR., Gren Z. Wang
  • Spiroindolines as modulators of chemokine receptors
    Patent number: 8431590
    Abstract: The present invention relates to a compound of the following formula: where R1-R6, R10, Y, n, m, p, and q are as defined herein. Compounds and compositions of the present invention are useful for the treatment of diseases associated with the overexpression of CCR2.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: April 30, 2013
    Assignee: Glaxo Group Limited
    Inventors: Brian W. Budzik, Hilary Schenck Eidam, Ryan Michael Fox, Krista B. Goodman, Dimitar B. Gotchev, Pamela A. Haile, Terry Vincent Hughes, Ronggang Liu, Nathan A. Miller, Tamara Ann Miskowski, Clark A. Sehon, Andrew Q. Viet, Gren Z. Wang, Jing Zhang
  • INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS
    Publication number: 20130023532
    Abstract: Disclosed are compounds having the formula: or a salt thereof, wherein A, n, R1, R1A, and R2 are as defined herein, and methods of making and using the same.
    Type: Application
    Filed: March 26, 2011
    Publication date: January 24, 2013
    Inventors: Linda N. Casillas, Subhas J. Chakravorty, Adam Kenneth Charnley, Pamela A. Haile, Terry Vincent Hughes, Jae U. Jeong, Jianxing Kang, Ami Lakdawala Shah, Lara Kathryn Leister, Robert W. Marquis, JR., Nathan Andrew Miller, Daniel J. Price, Clark A. Sehon, Gren Z. Wang, Daohua Zhang, Patrick Eidam
  • PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS
    Publication number: 20130023534
    Abstract: Disclosed are compounds having the formula (I): wherein Z, n, R1, R1A, R3, R4, and R5 are as defined herein, and methods of making and using the same.
    Type: Application
    Filed: March 26, 2011
    Publication date: January 24, 2013
    Inventors: Linda N. Casillas, Subhas J. Chakravorty, Patrick Eidam, Pamela A. Haile, Terry Vincent Hughes, Ami Lakdawala Shah, Lara Kathryn Leister, Nathan Andrew Miller, Attiq Rahman, Clark A. Sehon, Gren Z. Wang, Daohua Zhang
  • IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS
    Publication number: 20130018039
    Abstract: Disclosed are compounds having the formula: wherein R1A, R1B, R2 and R3 are defined herein, and methods of making and using the same.
    Type: Application
    Filed: March 31, 2011
    Publication date: January 17, 2013
    Inventors: Vera Q. Bodmer, Linda N. Casillas, Michael P. DeMartino, Philip A. Harris, Bryan W. King, Ami Lakdawala Shah, Lara Kathryn Leister, Joshi M. Ramanjulu, Joseph J. Romano, Gren Z. Wang, Matthew A. Wilson, David Duff Wisnoski
  • SPIROINDENES AND SPIROINDANES AS MODULATORS OF CHEMOKINE RECEPTORS
    Publication number: 20110124671
    Abstract: The present invention relates to a compound of the following formula: or a pharmaceutically acceptable salt thereof; where R1-R5, Y, m, n, and p are defined herein. Compounds and compositions of the present invention are useful the treatment of atherosclerosis.
    Type: Application
    Filed: August 14, 2008
    Publication date: May 26, 2011
    Inventors: Brian W. Budzik, Michael Jonathan Bury, Minghua Gu, Ronggang Liu, Feng Ren, Clark A. Sehon, Gren Z. Wang, Jing Zhang
  • SPIROINDOLINES AS MODULATORS OF CHEMOKINE RECEPTORS
    Publication number: 20110034499
    Abstract: The present invention relates to a compound of the following formula: where R1-R6, R10, Y, n, m, p, and q are as defined herein. Compounds and compositions of the present invention are useful for the treatment of diseases associated with the overexpression of CCR2.
    Type: Application
    Filed: June 20, 2008
    Publication date: February 10, 2011
    Inventors: Brian W. Budzik, Hilary Schenck Eidam, Ryan Michael Fox, Krista B. Goodman, Dimitar B. Gotchev, Pamela A. Haile, Terry Vincent Hughes, Ronggang Liu, Nathan A. Miller, Tamara Ann Miskowski, Clark A. Sehon, Andrew Q. Viet, Gren Z. Wang, Jing Zhang
  • MORPHOLINYL AND PYRROLIDINYL ANALOGS
    Publication number: 20100256130
    Abstract: The present invention relates to morpholinyl, and pyrrolidinyl analogs, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
    Type: Application
    Filed: May 19, 2010
    Publication date: October 7, 2010
    Inventors: Krista B. Goodman, Michael J. Neeb, Clark A. Sehon, Andrew Q. Viet, Gren Z. Wang
  • Morpholinyl and pyrrolidinyl analogs
    Patent number: 7749998
    Abstract: The present invention relates to morpholinyl, and pyrrolidinyl analogs, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
    Type: Grant
    Filed: July 20, 2007
    Date of Patent: July 6, 2010
    Assignee: GlaxoSmithKline LLC
    Inventors: Krista B. Goodman, Michael J. Neeb, Clark A. Sehon, Andrew Q. Viet, Gren Z. Wang
  • MORPHOLINYL AND PYRROLIDINYL ANALOGS
    Publication number: 20090275571
    Abstract: The present invention relates to morpholinyl, and pyrrolidinyl analogs, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
    Type: Application
    Filed: July 20, 2007
    Publication date: November 5, 2009
    Inventors: Krista B. Goodman, Michael J. Neeb, Clark A. Sehon, Andrew Q. Viet, Gren Z. Wang
  • Morpholinyl and pyrrolidinyl analogs
    Patent number: 7432258
    Abstract: The present invention relates to 4?-[(1R)-1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin- 4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylcarboxylic acid and its pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
    Type: Grant
    Filed: July 20, 2007
    Date of Patent: October 7, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Krista B. Goodman, Michael J. Neeb, Clark A. Sehon, Andrew Q. Viet, Gren Z. Wang
  • Novel Inhibitors of Rho-Kinases
    Publication number: 20080125427
    Abstract: Novel inhibitors of Rho-kinases are disclosed.
    Type: Application
    Filed: June 17, 2005
    Publication date: May 29, 2008
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Clark A. Sehon, Dennis Lee, Krista B. Goodman, Gren Z. Wang, Andrew Q. Viet