Abstract: Described herein is the use of a LOXL2 inhibitor in the treatment or prevention of conditions, diseases, or disorders associated with LOXL2 activity.

Abstract: Described herein is the use of a LOXL2 inhibitor in the treatment or prevention of conditions, diseases, or disorders associated with LOXL2 activity.

Abstract: Described herein are methods and compositions for the treatment of conditions, diseases, or disorders associated with autotaxin activity. The methods and compositions disclosed herein include the use of at least one autotaxin inhibitor compound.

Abstract: Described herein are methods and compositions for the treatment of conditions, diseases, or disorders associated with autotaxin activity. The methods and compositions disclosed herein include the use of at least one autotaxin inhibitor compound.

Abstract: Described herein are probe compounds that interact with the LOXL2 receptor, methods of making such probe compounds, and methods of using such probe compounds in vitro and in vivo.

Abstract: Described herein is the use of a LOXL2 inhibitor in the treatment or prevention of conditions, diseases, or disorders associated with LOXL2 activity.

Abstract: Described herein are methods and compositions for the treatment of conditions, diseases, or disorders associated with autotaxin activity. The methods and compositions disclosed herein include the use of at least one autotaxin inhibitor compound.

Abstract: Methods for the detection of DP2 receptors in biological samples is disclosed. The induction and detection of DP2 receptors expressed on activated human neutrophils is presented. Also presented are diagnostic kits for the detection of DP2 receptors in biological samples.

Abstract: The instant invention is directed to methods for treating neurodegenerative diseases comprises administering an effective amount of a selective histone deacetylase 8 inhibitor to a patient in need thereof.

Abstract: The invention provides a novel expression cloning technique referred to as a matrix analysis of gene expression in cells (MAGEC) that allows for the indexed introduction, and analysis of nucleic acids in a host cell. While normally one takes cells attached to a surface followed by contacting the cells with heterologous DNA under conditions favoring the uptake of the heterologous DNA, the present invention, in sharp contrasts, proposes affixing (depositing) a nucleic acid-containing mixture onto a suitable surface and thereafter contacting suitable host cells (target cells) with the DNA-containing markings under conditions favoring uptake by the cells of the heterologous expression vector comprising a the target nucleic slide acid molecule. The method enables one to further characterize the gene product(s) of a known gene and unknown in a high-throughput assay format. It essentially allows for the identification of a gene based upon the function of its gene product.