Patents by Inventor Gretchen M. Schroeder

Gretchen M. Schroeder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BENZOFURAN COMPOUNDS AS STING AGONISTS
    Publication number: 20240109899
    Abstract: The present invention is directed to compounds of formula (I) and (II), wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
    Type: Application
    Filed: February 3, 2022
    Publication date: April 4, 2024
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: BRIAN E. FINK, EMILY CHARLOTTE CHERNEY, LIPING ZHANG, JULIAN C. LO, GRETCHEN M. SCHROEDER, TRAM N. HUYNH, DONNA D. WEI, VIJAY T. AHUJA, CLAUDE A. QUESNELLE
  • CXCR4 receptor antagonists
    Patent number: 10450318
    Abstract: The invention generally relates to compounds of formula I which are antagonists of CXCR4. The invention includes pharmaceutically acceptable salts, compositions, methods of making the compounds of formula I, and methods of using the compounds of formula I for therapeutic indications.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: October 22, 2019
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gretchen M. Schroeder, Tram N. Huynh, Heidi L. Perez
  • CXCR4 RECEPTOR ANTAGONISTS
    Publication number: 20180327409
    Abstract: The invention generally relates to compounds of formula I which are antagonists of CXCR4. The invention includes pharmaceutically acceptable salts, compositions, methods of making the compounds of formula I, and methods of using the compounds of formula I for therapeutic indications.
    Type: Application
    Filed: December 14, 2016
    Publication date: November 15, 2018
    Inventors: Gretchen M. Schroeder, Tram N. Huynh, Heidi L. Perez
  • Tubulysin analogs and methods of making and use
    Patent number: 10077287
    Abstract: Tubulysin analogs of the formula (I) where R1, R2 R3, R4, R5, R6, R7, and Y are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: September 18, 2018
    Assignee: Bristol-Myers Squibb Company
    Inventors: Heidi L. Perez, Donna Wei, Robert M. Borzilleri, Sanjeev Gangwar, Gretchen M. Schroeder, Heng Cheng, Robert J. Schmidt
  • Macrocyclic benzodiazepine dimers, conjugates thereof, preparation and uses
    Patent number: 9902740
    Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: February 27, 2018
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yong Zhang, Robert M. Borzilleri, Andrew J. Tebben, Erik M. Stang, Andrew F. Donnell, Gretchen M. Schroeder, Heidi L. Perez, Donna D. Wei
  • MACROCYCLIC BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, PREPARATION AND USES
    Publication number: 20170260205
    Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
    Type: Application
    Filed: May 26, 2017
    Publication date: September 14, 2017
    Inventors: Yong ZHANG, Robert M. BORZILLERI, Andrew J. TEBBEN, Erik STANG, Andrew F. DONNELL, Gretchen M. SCHROEDER, Heidi L. PEREZ, Donna D. WEI
  • Macrocyclic benzodiazepine dimers, conjugates thereof, preparation and uses
    Patent number: 9688694
    Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: June 27, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yong Zhang, Robert M. Borzilleri, Andrew J. Tebben, Erik M. Stang, Andrew F. Donnell, Gretchen M. Schroeder, Heidi L. Perez, Donna D. Wei
  • MACROCYCLIC BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, PREPARATION AND USES
    Publication number: 20160376288
    Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
    Type: Application
    Filed: June 22, 2016
    Publication date: December 29, 2016
    Inventors: Yong ZHANG, Robert M. BORZILLERI, Andrew J. TEBBEN, Erik M. STANG, Andrew F. DONNELL, Gretchen M. SCHROEDER, Heidi L. PEREZ, Donna D. WEI
  • Substituted sulfonamides useful as antiapoptotic Bcl inhibitors
    Patent number: 9346795
    Abstract: Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: May 24, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert M. Borzilleri, Zhen-Wei Cai, Andrew J. Tebben, Heidi L. Perez, Liping Zhang, Gretchen M. Schroeder, Donna D. Wei
  • TUBULYSIN ANALOGS AND METHODS OF MAKING AND USE
    Publication number: 20160130299
    Abstract: Tubulysin analogs of the formula (I) where R1, R2 R3, R4, R5, R6, R7, and Y are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
    Type: Application
    Filed: August 24, 2015
    Publication date: May 12, 2016
    Inventors: Heidi L. PEREZ, Donna WEI, Robert M. BORZILLERI, Sanjeev GANGWAR, Gretchen M. SCHROEDER, Heng CHENG, Robert J. SCHMIDT
  • SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS
    Publication number: 20140135318
    Abstract: Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds.
    Type: Application
    Filed: May 23, 2012
    Publication date: May 15, 2014
    Applicant: Bristol-Myers Squibb Company
    Inventors: Robert M. Borzilleri, Zhen-Wei Cai, Andrew J. Tebben, Heidi L. Perez, Liping Zhang, Gretchen M. Schroeder, Donna D. Wei
  • JAK2 inhibitors and their use for the treatment of myeloproliferative diseases and cancer
    Patent number: 8673933
    Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of JAK2, thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: March 18, 2014
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ashok V. Purandare, James W. Grebinski, Amy C. Hart, Jennifer Inghrim, Gretchen M. Schroeder, Honghe Wan
  • Pyridinone compounds
    Patent number: 8536200
    Abstract: The invention is directed to pyridinone compounds useful for modulating Met kinase, having the following structure: and is further directed to pharmaceutical compositions comprising the compound; and methods for treating proliferative diseases, such as cancer by the administration of this compound.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: September 17, 2013
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert M. Borzilleri, Gretchen M. Schroeder, Zhen-Wei Cai
  • PHARMACEUTICAL COMPOSITIONS COMPRISING N-(4-(2-AMINO-3-CHLOROPYRIDIN-4-YLOXY)-3-FLUOROPHENYL)-4-ETHOXY-1-(4-FLUOROPHENYL)-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE
    Publication number: 20130039989
    Abstract: Disclosed are salts and crystalline forms of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide and salts thereof. Also disclosed are at least one pharmaceutical composition comprising at least one crystalline form of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, at least one method of using at least one crystalline form of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide to treat cancer and/or other proliferative diseases, and processes to prepare crystalline forms of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide and salts thereof.
    Type: Application
    Filed: April 29, 2011
    Publication date: February 14, 2013
    Inventors: Dilbir S. Bindra, Yeshwant Gokhale, Cletus John Nunes, Victor W. Rosso, Gretchen M. Schroeder, Ajit B. Thakur, Xiaotian Yin
  • Monocyclic heterocycles as kinase inhibitors
    Patent number: 7989477
    Abstract: The present invention is directed to compounds having the formula and methods for using them for the treatment of cancer.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: August 2, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert M. Borzilleri, Lyndon A. M. Cornelius, Robert J. Schmidt, Gretchen M. Schroeder, Kyoung S. Kim
  • PYRIDINONE COMPOUNDS
    Publication number: 20110052583
    Abstract: The invention is directed to pyridinone compounds useful for modulating Met kinase, having the following structure: and is further directed to pharmaceutical compositions comprising the compound; and methods for treating proliferative diseases, such as cancer by the administration of this compound.
    Type: Application
    Filed: November 8, 2010
    Publication date: March 3, 2011
    Inventors: Robert M. Borzilleri, Gretchen M. Schroeder, Zhen-Wei Cai
  • Pyridinone compounds
    Patent number: 7851489
    Abstract: The invention is directed to pyridinone compounds useful for modulating Met kinase, having the following structure: and is further directed to pharmaceutical compositions comprising the compound; and methods for treating proliferative diseases, such as cancer by the administration of this compound.
    Type: Grant
    Filed: November 8, 2007
    Date of Patent: December 14, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert M. Borzilleri, Gretchen M. Schroeder, Zhen-Wei Cai
  • MONOCYCLIC HETEROCYCLES AS KINASE INHIBITORS
    Publication number: 20100183606
    Abstract: The present invention is directed to compounds having the formula and methods for using them for the treatment of cancer.
    Type: Application
    Filed: March 19, 2010
    Publication date: July 22, 2010
    Inventors: ROBERT M BORZILLERI, Lyndon A.M. Cornelius, Robert J. Schmidt, Gretchen M. Schroeder, Kyoung S. Kim
  • Monocyclic heterocycles as kinase inhibitors
    Patent number: 7714138
    Abstract: The present invention is directed to compounds having the formula and methods for using them for the treatment of cancer.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: May 11, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert M. Borzilleri, Lyndon A. M. Cornelius, Robert J. Schmidt, Gretchen M. Schroeder, Kyoung S. Kim
  • MONOCYCLIC HETEROCYCLES AS KINASE INHIBITORS
    Publication number: 20090054436
    Abstract: The present invention is directed to compounds having the formula and methods for using them for the treatment of cancer.
    Type: Application
    Filed: October 17, 2008
    Publication date: February 26, 2009
    Inventors: Robert M. Borzilleri, Lyndon A.M. Cornelius, Robert J. Schmidt, Gretchen M. Schroeder, Kyoung S. Kim