Patents by Inventor Gretchen Yinbon Lam

Gretchen Yinbon Lam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12084712
    Abstract: Disclosed herein include systems, methods, compositions, and kits for sample identification. A sample indexing composition can comprise, for example, a protein binding reagent associated with a sample indexing oligonucleotide. Different sample indexing compositions can include sample indexing oligonucleotides with different sequences. Sample origin of cells can be identified based on the sequences of the sample indexing oligonucleotides. Sample indexing oligonucleotides can be barcoded using barcoded and lengthened using daisy-chaining primers.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: September 10, 2024
    Assignee: Becton, Dickinson and Company
    Inventors: Christina Chang, Christina Fan, Eleen Shum, Jody Martin, Nidhanjali Bansal, James Ghadiali, Katherine Lazaruk, Gretchen Yinbon Lam
  • Publication number: 20240254538
    Abstract: Disclosed herein are methods, compositions, and kits for barcoding nucleic acids. For example, particles for barcoding are provided, where the particle comprises: a first plurality of oligonucleotide barcodes each comprising a target-binding region, and a second plurality of oligonucleotides each comprising a target-specific target-binding region.
    Type: Application
    Filed: December 22, 2023
    Publication date: August 1, 2024
    Inventors: Gretchen Yinbon Lam, Eleen Shum
  • Patent number: 11946095
    Abstract: Disclosed herein are methods, compositions, and kits for barcoding nucleic acids. For example, particles for barcoding are provided, where the particle comprises: a first plurality of oligonucleotide barcodes each comprising a target-binding region, and a second plurality of oligonucleotides each comprising a target-specific target-binding region.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: April 2, 2024
    Assignee: Becton, Dickinson and Company
    Inventors: Gretchen Yinbon Lam, Eleen Shum
  • Publication number: 20230125113
    Abstract: Some embodiments disclosed herein provide a plurality of compositions each comprising a protein binding reagent conjugated with an oligonucleotide. The oligonucleotide comprises a unique identifier for the protein binding reagent it is conjugated with, and the protein binding reagent is capable of specifically binding to a protein target. Further disclosed are methods and kits for quantitative analysis of a plurality of protein targets in a sample and for simultaneous quantitative analysis of protein and nucleic acid targets in a sample. Also disclosed herein are systems and methods for preparing a labeled biomolecule reagent, including a labeled biomolecule agent comprising a protein binding reagent conjugated with an oligonucleotide.
    Type: Application
    Filed: August 22, 2022
    Publication date: April 27, 2023
    Inventors: Christina Fan, Christina Chang, Eleen Shum, Olaf Zoellner, Nidhanjali Bansal, James Ghadiali, Gretchen Yinbon Lam, Eric Jensen, Jurg Rohrer, Brent Gaylord, Jody Martin, Jason G. Vidal
  • Publication number: 20220333185
    Abstract: The disclosure provides for methods, compositions, systems, devices, and kits for whole transcriptome amplification using stochastic barcodes.
    Type: Application
    Filed: March 1, 2022
    Publication date: October 20, 2022
    Inventors: Glenn Fu, Craig Betts, Christina Fan, Gretchen Yinbon Lam
  • Patent number: 11460468
    Abstract: Some embodiments disclosed herein provide a plurality of compositions each comprising a protein binding reagent conjugated with an oligonucleotide. The oligonucleotide comprises a unique identifier for the protein binding reagent it is conjugated with, and the protein binding reagent is capable of specifically binding to a protein target. Further disclosed are methods and kits for quantitative analysis of a plurality of protein targets in a sample and for simultaneous quantitative analysis of protein and nucleic acid targets in a sample. Also disclosed herein are systems and methods for preparing a labeled biomolecule reagent, including a labeled biomolecule agent comprising a protein binding reagent conjugated with an oligonucleotide.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: October 4, 2022
    Assignee: Becton, Dickinson and Company
    Inventors: Christina Fan, Christina Chang, Eleen Shum, Olaf Zoellner, Nidhanjali Bansal, James Ghadiali, Gretchen Yinbon Lam, Eric Jensen, Jurg Rohrer, Brent Gaylord, Jody Martin, Jason G. Vidal
  • Patent number: 11390914
    Abstract: The disclosure provides for methods, compositions, systems, devices, and kits for whole transcriptome amplification using stochastic barcodes.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: July 19, 2022
    Assignee: Becton, Dickinson and Company
    Inventors: Glenn Fu, Craig Betts, Christina Fan, Gretchen Yinbon Lam
  • Publication number: 20210054436
    Abstract: Disclosed herein are methods, compositions, and kits for barcoding nucleic acids. For example, particles for barcoding are provided, where the particle comprises: a first plurality of oligonucleotide barcodes each comprising a target-binding region, and a second plurality of oligonucleotides each comprising a target-specific target-binding region.
    Type: Application
    Filed: December 18, 2018
    Publication date: February 25, 2021
    Inventors: Gretchen Yinbon Lam, Eleen Shum
  • Publication number: 20200385780
    Abstract: Disclosed herein include systems, methods, compositions, and kits for sample identification. A sample indexing composition can comprise, for example, a protein binding reagent associated with a sample indexing oligonucleotide. Different sample indexing compositions can include sample indexing oligonucleotides with different sequences. Sample origin of cells can be identified based on the sequences of the sample indexing oligonucleotides. Sample indexing oligonucleotides can be barcoded using barcoded and lengthened using daisy-chaining primers.
    Type: Application
    Filed: April 14, 2020
    Publication date: December 10, 2020
    Inventors: Christina Chang, Christina Fan, Eleen Shum, Jody Martin, Nidhanjali Bansal, James Ghadiali, Katherine Lazaruk, Gretchen Yinbon Lam
  • Patent number: 10676779
    Abstract: Disclosed herein include systems, methods, compositions, and kits for sample identification. A sample indexing composition can comprise, for example, a protein binding reagent associated with a sample indexing oligonucleotide. Different sample indexing compositions can include sample indexing oligonucleotides with different sequences. Sample origin of cells can be identified based on the sequences of the sample indexing oligonucleotides. Sample indexing oligonucleotides can be barcoded using barcoded and lengthened using daisy-chaining primers.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: June 9, 2020
    Assignee: Becton, Dickinson and Company
    Inventors: Christina Chang, Christina Fan, Eleen Shum, Jody Martin, Nidhanjali Bansal, James Ghadiali, Katherine Lazaruk, Gretchen Yinbon Lam
  • Publication number: 20200157600
    Abstract: The disclosure provides for methods, compositions, systems, devices, and kits for whole transcriptome amplification using stochastic barcodes.
    Type: Application
    Filed: November 19, 2018
    Publication date: May 21, 2020
    Inventors: Glenn Fu, Craig Betts, Christina Fan, Gretchen Yinbon Lam
  • Publication number: 20180346970
    Abstract: Disclosed herein include systems, methods, compositions, and kits for sample identification. A sample indexing composition can comprise, for example, a protein binding reagent associated with a sample indexing oligonucleotide. Different sample indexing compositions can include sample indexing oligonucleotides with different sequences. Sample origin of cells can be identified based on the sequences of the sample indexing oligonucleotides. Sample indexing oligonucleotides can be barcoded using barcoded and lengthened using daisy-chaining primers.
    Type: Application
    Filed: March 27, 2018
    Publication date: December 6, 2018
    Inventors: Christina Chang, Christina Fan, Eleen Shum, Jody Martin, Nidhanjali Bansal, James Ghadiali, Katherine Lazaruk, Gretchen Yinbon Lam
  • Publication number: 20180088112
    Abstract: Some embodiments disclosed herein provide a plurality of compositions each comprising a protein binding reagent conjugated with an oligonucleotide. The oligonucleotide comprises a unique identifier for the protein binding reagent it is conjugated with, and the protein binding reagent is capable of specifically binding to a protein target. Further disclosed are methods and kits for quantitative analysis of a plurality of protein targets in a sample and for simultaneous quantitative analysis of protein and nucleic acid targets in a sample. Also disclosed herein are systems and methods for preparing a labeled biomolecule reagent, including a labeled biomolecule agent comprising a protein binding reagent conjugated with an oligonucleotide.
    Type: Application
    Filed: September 25, 2017
    Publication date: March 29, 2018
    Inventors: Christina Fan, Christina Chang, Eleen Shum, Olaf Zoellner, Nidhanjali Bansal, James Ghadiali, Gretchen Yinbon Lam, Eric Jensen, Jurg Rohrer, Brent Gaylord, Jody Martin, Jason G. Vidal
  • Publication number: 20160312276
    Abstract: The disclosure provides for methods, compositions, systems, devices, and kits for whole transcriptome amplification using stochastic barcodes.
    Type: Application
    Filed: April 21, 2016
    Publication date: October 27, 2016
    Inventors: Glenn Fu, Craig Betts, Christina Fan, Gretchen Yinbon Lam