Abstract: Two or three pulsed laser (3, 4, 20) devices are provided with a system for the automated optimization of the parameters of radiation produced by these lasers as well the types and regimes of processing of each kind of tissue. The outputs of at least one detector (15) of information about the status of tissue (16) that is under processing are connected to the inputs of control unit 1 which output signals are applied to electronic switchers (5, 6, 26) placed in the circuits connecting the power supply (2) with each of lasers (3, 4, 20). The devices also include the controlled system of treatment zone irrigation (17) and a system for laser radiations mixing consisting of reflective (7, 21) and selective (8, 25) mirrors that makes it possible to provide the independent radiation outputs.