Patents by Inventor Grigory Filonov

Grigory Filonov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FRET Biosensor for Detecting and Reporting NAD+/NADH Ratio Changes
    Publication number: 20240026420
    Abstract: FRET-based fusion protein biosensors and methods for their use in measuring an NAD+/NADH ratio change in live cells are provided.
    Type: Application
    Filed: July 12, 2022
    Publication date: January 25, 2024
    Inventors: Grigory Filonov, Cicely Schramm
  • METHOD FOR MONITORING LIVE CELLS
    Publication number: 20230360200
    Abstract: A method for monitoring one or more live cells includes capturing a non-fluorescence image of a sample that includes one or more live cells that further contain fluorescent protein-based nuclear translocation reporters (FTRs), capturing a fluorescence image of the FTRs in the live cell(s) in the sample, identifying, via a computational model, nuclear pixels of the non-fluorescence image that correspond to nuclei of the live cell(s), identifying, based on the nuclear pixels, first pixels of the fluorescence image that correspond to the nuclei and second pixels of the fluorescence image that do not correspond to the nuclei, and calculating, based on first intensities of the first pixels and second intensities of the second pixels, a metric representing a first amount of the FTRs located within the nuclei of the live cell(s) and a second amount of the FTRs not located within the nuclei of the live cell(s).
    Type: Application
    Filed: May 9, 2022
    Publication date: November 9, 2023
    Inventors: Elsa Sörman Paulsson, Christoffer Edlund, Grigory Filonov, Cicely Schramm, Rickard Sjögren
  • METHODS AND COMPOSITIONS FOR LIVE CELL ANALYSIS OF INTRACELLULAR ATP
    Publication number: 20200400670
    Abstract: Disclosed herein are ATP biosensor fusion proteins and their use for assaying ATP levels in cells.
    Type: Application
    Filed: March 7, 2019
    Publication date: December 24, 2020
    Inventors: Daniel APPLEDORN, Cicely SCHRAMM, Grigory FILONOV, Kirk SCHROEDER
  • RNA sequences that induce fluorescence of small molecule fluorophores
    Patent number: 9664676
    Abstract: The present invention relates to novel nucleic acid molecules, called aptamers, that bind specifically to a small molecule fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: May 30, 2017
    Assignee: Cornell University
    Inventors: Samie R. Jaffrey, Rita L. Strack, Grigory Filonov, Wenjiao Song
  • RNA SEQUENCES THAT INDUCE FLUORESCENCE OF SMALL MOLECULE FLUOROPHORES
    Publication number: 20150141282
    Abstract: The present invention relates to novel nucleic acid molecules, called aptamers, that bind specifically to a small molecule fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described.
    Type: Application
    Filed: September 8, 2014
    Publication date: May 21, 2015
    Inventors: Samie R. Jaffrey, Rita L. Strack, Grigory Filonov, Wenjiao Song